Reproductive Biology and Fertility

Apoptosis promotes fertility in C. elegans by maintaining functional germline morphology

This study shows that apoptosis in C. elegans maintains germline structure and fertility by preventing morphological defects and ensuring proper oocyte development.

A complex phenotypic assay of mammalian oocyte maturation identifies compounds that block meiotic progression for non-hormonal contraceptive discovery

This study screens compounds to identify those that block meiotic progression in mouse oocytes, offering potential non-hormonal contraceptive candidates.

Maternal age and genome-wide failure of meiotic recombination are associated with triploid conceptions in humans

The paper investigates the association between maternal age and meiotic recombination failure with triploid/haploid conceptions in humans, identifying a maternal age effect and new types of genome-wide maternal isodiploidy.

Single-cell exploration of ovarian aging across mammalian models

This study analyzes ovarian aging across species using single-cell RNA-seq data to identify conserved and species-specific features and suggests drug repurposing candidates.

In Vitro Fertilization Accelerates Female Reproductive Aging Through Early Ovarian Failure

This study shows that in vitro fertilization (IVF) accelerates reproductive aging in female mice by causing premature ovarian failure, with altered ovarian function and epigenetic changes.

Comparative analysis of human and mouse ovaries across age

This study compares human and mouse ovarian biology across age using 3D-imaging, single-cell transcriptomics, and functional studies, identifying species-specific and age-related changes in follicle dynamics and gene expression.

Enhancing the cryopreservation of ex vivo 3D tumor models using vitrification strategies

This study optimizes vitrification protocols to enhance the preservation of ex vivo 3D tumor models, achieving high proliferative capacity retention.

A mechanical origin for implantation defects in embryos from aged females

This study identifies a mechanical defect in embryos from aged mothers that impairs implantation, showing increased trophectoderm contractility leads to defective spreading during implantation.

Ovarian development is driven by early spatiotemporal priming of the coelomic epithelium

This study shows that ovarian cellular diversity arises from spatially organized, transcriptionally heterogeneous coelomic epithelium progenitors in fetal mouse and human ovaries, which are primed toward supporting or steroidogenic identities.

Transcriptomic and proteomic dynamics of ovarian follicle group culture resemble in vivo folliculogenesis

This study examines the transcriptomic and proteomic changes in cultured ovarian follicles, identifying gene expression patterns and differentially expressed genes between group culture conditions.

Critical phenomenon underlies de novo luminogenesis during mammalian follicle development

The paper investigates the spatiotemporal dynamics of lumen formation in mammalian follicles, revealing a critical phenomenon involving fluid networks and cell death.

Analysis of oogenesis defects in Dyro mutant of Drosophila melanogaster.

This study investigates oogenesis defects in Dyro mutant Drosophila melanogaster, identifying nuclear abnormalities and protein aggregation in nurse cells as key factors in female sterility.

Ergothioneine and a new food supplement product protectagainst cyclophosphamide-induced premature ovarianfailure in rats

This study shows that ergothioneine and a nutraceutical formula protect against cyclophosphamide-induced premature ovarian failure in rats by reducing oxidative stress and inflammation.

Defining the cell and molecular origins of the primate ovarian reserve

The paper investigates the cell and molecular origins of the primate ovarian reserve using rhesus macaques, identifying PG2 cells as the primary source of primordial follicles and describing the recruitment of fetal theca cells for hormone production.

High-Yield Induced Ovulation in Adult Fat-Tailed Dunnarts by PMSG Treatment Combined with Estrus Synchronization

This study develops a protocol to induce high-yield ovulation in adult fat-tailed dunnarts using estrus synchronization and PMSG-hCG treatment, resulting in a high number of mature MII oocytes.

Neonatal Mouse Ovary Culture: An In Vitro Model for Studying Primordial Follicle Regulation

The paper describes a method for culturing postnatal mouse ovaries on membrane inserts to study primordial follicle dynamics and demonstrates its impact on follicle count.

Mouse germline cysts contain a fusome that mediates oocyte development

The paper identifies a fusome in mouse germline cysts that mediates oocyte development by establishing polarity and asymmetric distribution of cellular components.

Chromosome Ageing Occurs at the Primordial Follicle Stage in both Mouse and Human Oocytes

The paper shows that chromosome ageing, marked by increased chromatid separation and cohesin depletion, occurs in primordial follicles in both mouse and human oocytes.

Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

This study uses phosphoproteomics to analyze protein phosphorylation during Xenopus oocyte meiotic divisions, revealing key phosphorylation events and their roles in meiotic processes.

The proteostatic landscape of healthy human oocytes

This study analyzes proteostasis in human oocytes, finding reduced degradative activity and mitochondrial membrane potential during maturation, suggesting preserved cellular components.

Thioredoxin-1 inhibits granulosa cell ferroptosis to rescue ovarian aging through mitophagy-dependent activation of BNIP3L

This study shows that Thioredoxin-1 prevents granulosa cell ferroptosis by promoting mitophagy, thereby improving ovarian aging and fertility in mice.

The Effects of Heat Stress on the Ovary, Follicles and Oocytes: A Systematic Review

This systematic review summarizes evidence on heat stress's adverse effects on mammalian oocytes and ovaries, highlighting impaired function and reduced quality.

An Epigenomic Roadmap Primes Non-Growing Oocytes for Maturation and Early Embryogenesis

This study shows that non-growing oocytes in mice have pre-established epigenetic marks that prime the epigenome for oocyte maturation and early embryogenesis, challenging the traditional view that these marks are acquired after ovarian reserve exit.

Single-oocyte transcriptional profile of early-stage human oocytes reveals differentially expressed genes in the primordial and transitioning stages.

The paper analyzes single-oocyte RNA sequencing data from early-stage human follicles to identify differentially expressed genes between primordial and transitioning stages.

Single-cell and spatiotemporal profile of ovulation in the mouse ovary

This study maps the spatiotemporal profile of ovulation in mice using single-cell RNA-seq and spatial transcriptomics, identifying cell state markers and interactions involved in the process.

Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures

This study identifies multinucleated giant cells (MNGCs) in aging ovaries, showing their unique immune and degradation-related molecular signatures through transcriptomic and imaging analyses.

PARP1 regulates establishment of the ovarian reserve and age at natural menopause

This study identifies a variant in PARP1 associated with earlier menopause by affecting primordial germ cell fate through altered DNA binding and transcriptional regulation.

Systematic characterization of the ovarian landscape across mouse menopause models

This study systematically compares three mouse menopause models to identify shared and model-specific features of follicle loss and endocrine disruption using single-cell transcriptomics and machine learning.

Oviductin sets the species-specificity of the mammalian zona pellucida

The paper shows that OVGP1, an oviductal glycoprotein, confers species-specificity to the zona pellucida by modulating sperm-oocyte binding.

Single-cell analysis of ovarian myeloid cells identifies aging associated changes in macrophages and signaling dynamics

The paper uses single-cell RNA sequencing and flow cytometry to analyze myeloid cells in young and aged mouse ovaries, identifying aging-related changes in macrophage subsets and signaling pathways.