Neurogenesis and neuroplasticity mechanisms

A Role for Astrocyte Metabolism in Species-Specific Neuronal Development

This study shows that human astrocytes have distinct metabolic profiles compared to non-human primate astrocytes, which influence neuronal development timing and trajectories.

Organoids reveal niche-specific mechanotransduction-guided human cortical patterning and cell fate acquisition

This study uses organoids to show that disrupting the LINC complex affects human cortical cell fate and organization by altering mechanosensing and nuclear mechanics.

Brain injury reactivates a developmental program driving genesis and integration of transient LGE-class interneurons

The paper shows that brain injury reactivates a developmental program in astrocytes to generate transient LGE-class interneurons that integrate into neural circuits.

ABERRANT HIPPOCAMPAL NEUROGENESIS IS A CONSERVED RESPONSE TO STROKE IN MICE: A MULTI-CENTER MULTIMODEL STUDY

This study shows that stroke increases hippocampal neurogenesis but leads to maladaptive morphological features in newborn neurons across multiple mouse stroke models.

Developmental signaling reveals functionally enriched human-specific gene regulation in telencephalic progenitors

The paper identifies human-specific gene regulation in telencephalic progenitors by analyzing morphogen-dependent gene expression responses across human, chimpanzee, and orangutan species.

Antagonizing niche signals regulate the emergence of postnatal neural stem cells and allow enlargement of their pool

The paper identifies ECM remodeling differences between slowly and rapidly dividing RGCs that regulate aNSC emergence and pool size through in vivo perturbation and single-cell RNA-sequencing.

The atypical RHO-GTPase RND3/RHOE interacts with FLRT3 to regulate cortical migration and folding

This study identifies FLRT3-RND3 signaling as a conserved negative regulator of cortical neuron migration and folding in mice.

The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development; Eml3 null mice are a model of cobblestone brain malformation

This study shows that EML3 is essential for embryonic growth and cortical development, with its absence causing cobblestone brain malformation due to disrupted pial basement membrane structure.

Primate Astrocyte Evolution Controls the Tempo of Neuronal Development

This study shows human astrocytes delay neuronal maturation compared to chimpanzee astrocytes, linking astrocyte evolution to brain neoteny and disease vulnerability.

Stoichiometric transcription factor partnerships control GABAergic neuron fate allocation

The paper shows that the relative abundance of transcription factors SP9 and DLX determines neuronal fate allocation in the developing basal ganglia.

Progressive Lineage Restriction of Bergmann Glia-like Progenitors during Postnatal Cerebellar Development

The paper shows that Bergmann glia-like progenitors (BGLPs) progressively restrict their lineage potential during postnatal cerebellar development, producing fewer cell types over time.

Linking transcriptome to cell behavior in real time uncovers molecular fate-asymmetry and a quiescence cycle among adult neural stem cells

This study links transcriptomic data with real-time cell behavior to uncover molecular fate asymmetry and a quiescence cycle in adult neural stem cells.

A conserved lamination pattern in the paleocortex and the neocortex revealed by single-cell RNA analyses

The paper uses single-cell RNA sequencing to reveal a conserved laminar structure in the paleocortex and neocortex, identifying shared and distinct molecular programs across species.

Tissue lamination state switches neuronal translocation from active to passive in the vertebrate retina

The paper shows that neuronal migration in the vertebrate retina switches from active, microtubule-dependent translocation to passive, tissue-driven displacement depending on the tissue lamination state.

Pancreatic cancer disrupts the adult hippocampal neurogenic niche

This study shows pancreatic cancer impairs adult hippocampal neurogenesis, leading to depressive-like behaviors through systemic inflammation and cytokine effects.

Competing Programs Shape Cortical Sensorimotor-Association Axis Development

The paper presents the MIND model, showing that competing induction and exclusion programs shape the sensorimotor-to-association axis in the neocortex across species.

Spinal injury induces a stem cell-like progenitor state that promotes regenerative neurogenesis via clcf1 in zebrafish.

The paper identifies an injury-induced stem cell-like state in zebrafish ERGs that promotes regenerative neurogenesis through lin28a and clcf1.

Social Isolation Alters Hippocampal miR-30e-5p Expression and Impairs Pattern Separation-Related Behaviour in Adult Mice

This study shows that adult social isolation in mice increases miR-30e-5p expression in the hippocampus, reduces its target gene Neurod1, and impairs pattern separation without affecting anxiety or depression-like behaviors.

Deciphering Intercellular Communication in the Cerebellar External Granule Layer: Insights into Non-Classical Connections in Neural Development

The paper identifies and characterizes intercellular connections in the developing cerebellum, suggesting a potential new mode of communication during neural development.

Human dental pulp stem cells grafted into C57BL/6J hippocampus differentiate towards immature neuronal like cells displaying action potential firing activity

This study shows human dental pulp stem cells can survive and differentiate into immature neuronal-like cells in mouse hippocampus one month after grafting.

Optic nerve innervation promotes Wnt/b-catenin pathway activity and progenitor cell proliferation in the zebrafish optic tectum

The paper investigates how optic nerve innervation affects Wnt/b-catenin pathway activity and progenitor cell proliferation in zebrafish optic tectum, showing that innervation promotes survival and proliferation even in darkness.

Single-cell multiomic approaches define a gradual, spatially-regulated epigenetic and transcriptional transition from embryonic to adult neural stem cells

Intact learning and memory in mice incapable of de novo myelination

This study shows that motor and fear learning in mice do not require newly formed myelin sheaths or rapid saltatory conduction, as Mbp-cKO mice with impaired myelination still learned and remembered normally.

Dual Developmental Origins and Activity-dependent Specification of Mammalian Subplate Neurons

The paper identifies two distinct developmental origins of subplate neurons in mammals through comparative single-cell and spatial transcriptomics across amniotes.

Isolation of postnatal human neural stem cells

The paper isolates and characterizes two postnatal human neural stem cell subsets, showing their fate biases and decline in frequency over time.

Fatty acid binding protein-8 (FABP8/PMP2) reveals molecular heterogeneity of myelin sheaths in the human CNS

This paper identifies FABP8/PMP2 as a defining feature of human and old-world monkey CNS myelin, revealing molecular heterogeneity in myelin sheaths and its role in cholesterol enrichment.

Calpain-2 inhibition or deletion enhances levels of the transcription Factor, MEIS2, and stimulates neurogenesis

This study shows that inhibiting or deleting calpain-2 increases MEIS2 levels and promotes neurogenesis in adult mice by enhancing dendritic spine maturation.

Spatial and Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate Gyrus

This study maps the spatial and molecular changes in neural progenitor cells in the human dentate gyrus from gestation to postnatal stages, showing a decline in neurogenic potential and transition to astrocytic features.

Hypoxia increases neural proliferation, alters vascular structure, and reprograms the transcriptome and proteome of the speckled sanddab brain

This study examines how hypoxia affects neural proliferation, vascular structure, and molecular profiles in the speckled sanddab brain, revealing multi-level adaptations to low oxygen conditions.

Cortical folding patterns are encoded in the geometry of the unfolded neocortex.

This study shows that neocortical geometry at birth predicts adult cortical folding patterns and sulcal-gyral fate, suggesting geometry provides positional information alongside molecular signals.