Neurogenesis and neuroplasticity mechanisms

Prenatal assembly of functional cortical circuits

This study compares prenatal cortical development in two rodents, showing that major developmental milestones occur prenatally in Acomys, challenging the view that postnatal experience is essential for early brain maturation.

Comprehensive Characterization of the Human Neural Stem Cell Line HNSC.100 as a Versatile Model for Neurobiological Research

The paper characterizes the HNSC.100 neural stem cell line, showing its ability to differentiate into major neural cell types and providing gene expression data and markers for neurobiological research.

Sphingosine-1-Phosphate Receptor 1 regulates competition dependent astrocyte morphogenesis and tiling in murine cortex.

This study shows that S1PR1 regulates astrocyte morphogenesis and tiling in the developing murine cortex through competition and JAK-STAT3 signaling.

Adhesion-Controlled Mechanics of the Glial Niche Regulate Neural Stem Cell Proliferative Potential

This study shows that glial cell adhesion molecules regulate neural stem cell proliferation by modulating mechanical forces and nuclear integrity in Drosophila.

Olfactory learning potentiates long-range cortical GABAergic inputs onto adult-born neurons.

This study shows that olfactory learning enhances cortical GABAergic inputs onto adult-born neurons in the olfactory bulb, influencing olfactory behavior.

Microtubule binding protein Togaram1 is required for proper development of mammalian forebrain and neural primary cilia

This study investigates the role of Togaram1 in mammalian forebrain development using a mouse knockout, finding it crucial for forebrain size, morphology, and NSC primary cilia function.

Chronic Mild Stress Impairs Hippocampal Myelination through SOX6-Dependent Dysfunction of Oligodendrocyte Lineage Cells

This study identifies SOX6 as a key regulator of oligodendrocyte dysfunction under chronic stress, linking stress to myelination deficits through molecular mechanisms.

Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6-Dependent Interneuron Dysmaturation

This study uses human brain organoids to show that transient IL-6 exposure during prenatal development disrupts interneuron maturation and subtype specification, linking it to neurodevelopmental disorders.

Thalamus-derived glutamate is required for early specification of layer 4 neurons in the sensory cortex

This study shows that thalamus-derived glutamate, not VGF, is required for the proper production and specification of layer 4 neurons in the sensory cortex before synapse formation.

Glial cell states bias the regeneration of neuron types across the newt life cycle

The paper shows that glial cell states influence neuron regeneration in newts, with quiescent glial cells biasing the types of neurons regenerated across life stages.

A Novel MicroRNA-Odorant Receptor Axis Governs Neural Progenitor Cell Proliferation in Zebrafish CNS

This study identifies a novel miRNA-odorant receptor axis that regulates ERG cell proliferation in zebrafish spinal cord after injury.

Kif2C safeguards radial glial integrity to prevent cortical malformation

This study identifies Kif2C as a critical regulator of radial glial cell integrity, showing its role in preventing cortical malformations and linking its dysfunction to human neurodevelopmental disorders.

Targeting UBE3A and downstream estrogen receptor-β signaling to restore oligodendroglial homeostasis in Angelman syndrome

The paper identifies UBE3A-dependent regulation of oligodendroglial homeostasis via estrogen receptor-β signaling as a therapeutic target for Angelman syndrome.

Tbx1 Heterozygosity in the Oligodendrocyte Lineage Shifts Myelinated Axon Composition in the Mouse Fimbria Without Behavioral Impairments

This study shows that Tbx1 heterozygosity in the oligodendrocyte lineage causes a shift in myelinated axon composition in the mouse fimbria but not behavioral impairments.

Stage-specific exposure to an activity-permissive media enhances neuronal maturation in oligodendrocyte-enriched cortical organoids

This study shows that exposing oligodendrocyte-enriched cortical organoids to a specific medium during development enhances neuronal activity and maturation while preserving oligodendrocyte development.

Actin disassembly triggers CNS myelin compaction and wrapping

This study shows actin disassembly enables myelin compaction and wrapping in the CNS by developing live-cell assays and genetic perturbations.

Spatially resolved transcriptomics identifies intercellular signaling post-ischemic stroke that controls neural stem cell proliferation

The paper identifies intercellular signaling pathways post-ischemic stroke that regulate neural stem cell proliferation using spatial transcriptomics and computational analysis.

Intrinsic coordination of dynamic molecular signatures shape the human prefrontal cortex

The paper identifies YBX1 as a key transcription factor in shaping human prefrontal cortex molecular identity through CRISPR activation screens and organoid experiments.

Polo-like kinase 1 controls activation of adult neural stem cells and represents a druggable entry-point to boost adult neurogenesis

This study identifies Polo-like kinase 1 (Plk1) as a regulator of adult neural stem cell quiescence and activation, showing that its inhibition enhances neurogenesis.

Developmental gene expression patterns driving species-specific cortical features

The paper identifies JUNB as a gene driving species-specific cortical features by comparing gene expression in mouse, human, and human cortical organoids.

Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3

The paper shows that ependymal cell cilia beating regulates neural stem cell quiescence through mechanical forces involving PKD1/2 and TRPM3.

Frequency-Dependent Modulation of Adult Hippocampal Neurogenesis, Memory, and BDNF Signaling by Low-Intensity Focused Ultrasound

This study shows that low-intensity focused ultrasound (LIFU) at 0.5 MHz enhances adult hippocampal neurogenesis and memory in rats, while higher frequencies have weaker effects.

δ-catenin controls layer-specific transcriptional maturation of astrocytes via Zbtb20

This study shows that δ-catenin regulates astrocyte transcriptional maturation and circuit stabilization via Zbtb20, with loss of δ-catenin disrupting layer-specific astrocyte identities and prolonging ocular dominance plasticity.

Developmental temporal programs govern and maintain neuronal identity and function in adult circuits

This study identifies E93 as a retained developmental transcription factor that maintains neuronal identity and function in adult Drosophila circuits.

Inflammation-induced epigenetic memory restores oligodendrocyte progenitor cell regenerative capacity in the aged central nervous system

This study shows that inflammation-induced epigenetic memory in OPCs improves remyelination in aged mice by enhancing differentiation and reducing axonal damage.

A Three-Layered Agent-Based Model of Adult Hippocampal Neurogenesis (HANG-AB3L) with Stochastic Cell Fate Determination

This study uses an agent-based model to simulate hippocampal neurogenesis, showing that stochastic cell fate decisions lead to deterministic population stability through kinetic tuning of division probabilities.

Stage-specific CHI3L1/YKL-40 signaling controls generation of oligodendrocyte precursor cells through IL13Rα2-mediated ferroptosis

This study identifies CHI3L1/YKL-40 as a stage-specific regulator of oligodendrocyte precursor cell (OPC) generation through IL13Rα2-mediated ferroptosis, limiting OPC production and affecting their maintenance.

Adult-neurogenesis allows for representational stability and flexibility in early olfactory system

This study shows adult-neurogenesis supports both stable and flexible odor representations in the olfactory system through experience-dependent mechanisms in different brain regions.

Spontaneous network activity links misrouted interneuron migration to cortical maturation abnormalities

This study shows that disrupted migration of inhibitory neurons leads to persistent functional deficits in cortical networks, linking migratory guidance to circuit integrity.

mTORC1 supports progression toward activation competence in quiescent adult neural stem cells

This study shows mTORC1 supports quiescent NSCs in acquiring activation competence, challenging its role as solely a proliferation regulator.