Liver physiology and pathology

Liver Sinusoidal Endothelial Cells and Laminin dictate cholangiocytes fate in chronic liver disease

The paper identifies laminin and liver sinusoidal endothelial cells as key regulators of cholangiocyte fate in chronic liver disease, showing that preventing LSEC capillarization enhances DR differentiation into hepatocytes.

MAIT cells derived ligands signal via VEGFR2 to promote tissue repair and liver regeneration

This study identifies VEGFA, VEGFB, and vimentin as ligands expressed by MAIT cells that signal via VEGFR2 to promote tissue repair and liver regeneration.

Time-restricted feeding exacerbates liver fibrosis by promoting BDH1-mediated ketolysis in hepatic stellate cells.

This study shows that time-restricted feeding worsens liver fibrosis by increasing BDH1-mediated ketolysis in hepatic stellate cells.

Mapping vascular plasticity in liver fibrogenesis identifies novel fibrosis-associated endothelial cells in early-stage liver disease

The paper identifies novel fibrosis-associated endothelial cells in early-stage liver disease through integrated analysis of imaging, proteomic, and transcriptomic data.

The LIF-LIFR Axis Promotes Liver Regeneration via Modulation of Angiogenesis and HGF Release from LSECs

This paper identifies the LIF-LIFR axis as a key regulator of liver regeneration through LSECs, promoting angiogenesis and HGF release, and suggests therapeutic strategies for liver repair.

LiverMap pipeline for 3D imaging of human liver reveals volumetric spatial dysregulation of cirrhotic vasculobiliary architecture

The paper uses 3D imaging to analyze human liver tissue and identifies spatial dysregulation in cirrhotic vasculobiliary architecture.

A single-cell fixed RNA profiling of liver fibrosis progression and regression reveals SEMA4D and LMCD1 as key mediators of fibrogenesis

Scar-associated endothelial-stellate cellular crosstalk drives fibrosis resolution in MASH

This study identifies Wnt9b-Sfrp2 crosstalk between endothelial and stellate cells as a driver of fibrosis resolution in MASH using single-cell and spatial profiling.

Quantitative 3D imaging of mouse and human intrahepatic bile ducts in homeostasis and liver injury

This paper develops a 3D imaging and analysis pipeline for intrahepatic bile ducts in mouse and human tissues, revealing structural changes in health and disease.

Ginkgolic acid attenuates e chinococcus granulosus infection-induced hepatic fibrosis by inhibiting Smad4 SUMOylation

This study shows ginkgolic acid reduces hepatic fibrosis in cystic echinococcosis by inhibiting Smad4 SUMOylation and modulating immune cell interactions.

Lrat-Cre Exhibits Widespread Expression Beyond Hepatic Stellate Cells Across Multiple Tissues

Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages

This study shows that increased VCAM-1 in hepatic artery endothelial cells and portal fibroblasts recruits Spp1+ macrophages, driving fibrosis in portal hypertension.

Immunoglobulin G binding as a quantitative marker of hepatocellular death across acute and chronic liver injury

Endogenous immunoglobulin G (IgG) immunostaining quantitatively labels apoptotic and necrotic hepatocytes across acute and chronic murine liver injury models, outperforming serum transaminases and histopathological Ishak scoring.

Leronlimab a humanized anti-CCR5 monoclonal antibody ameliorates hepatic fibrosis in two preclinical fibrosis mouse models

This study evaluates leronlimab's antifibrotic effects in two mouse models of liver fibrosis, showing significant reduction in fibrosis area with 10 mg/kg/week doses.

Kupffer cells control neonatal hepatic metabolism via Igf1 signaling

This study shows that yolk sac-derived Kupffer cells regulate neonatal hepatocyte metabolism via Igf1 signaling, essential for glycogen storage and TCA cycle function.

Protective Anti-Fibrotic Effect of Liraglutide and Pirfenidone Combination Therapy on Liver Fibrosis in Rats: Effects on Autophagy and NLRP3 Inflammasome

This study shows that combining Liraglutide and Pirfenidone reduces liver fibrosis in rats by enhancing autophagy and suppressing NLRP3 inflammasome activation.

Human hepatic stellate cells orchestrate the accumulation and function of CD103+ tissue-resident CD8+ T-cells in liver fibrosis

An Integrated Single-Cell Atlas Reveals Hepatic Stellate Cell Heterogeneity and Spatiotemporal Dynamics after Liver Injury

This study constructs a cross-etiological HSC atlas to reveal HSC heterogeneity and spatiotemporal dynamics in liver injury, identifying a novel apoptosis-prone HSC subtype and a 531-gene fibrosis signature.

Diet-induced MASH liver fibrosis promoted by EphB2 can be targeted by small molecule tetramerization inhibitors

This study identifies EphB2 as a driver of MASH liver fibrosis and shows that targeting EphB2 with small molecule inhibitors can reduce fibrosis in mouse models.

Hepatocyte FGFR2 Mediates the Antifibrotic Effects of FGF10 in Advanced Liver Fibrosis.

This study identifies the hepatocyte FGF10-FGFR2 axis as a negative regulator of fibrogenesis, showing it can attenuate and reverse advanced liver fibrosis.

Liver size is predetermined in the neonate by adding lobules at the periphery

The paper identifies that neonatal vascularization, specifically angiogenesis in the hepatic vein periphery, determines adult liver size in mice by adding lobules.

Isolation of rat and human hepatic cholangiocytes using a peptide derived from a conserved domain of enterobacteria BamA/TamA-like proteins

The paper identifies a peptide that binds to cholangiocytes and uses it to isolate human and rat liver epithelial cells, revealing functional differences between small and large cholangiocytes.

BAP1 deletion in hepatocytes primes an inflammatory transcriptional response

This study shows that BAP1 deletion in hepatocytes leads to an inflammatory transcriptional response and impaired immune cell recruitment in the liver.

The HNF4A Q164X Mutation Impairs Transcriptional Activation in Vitro but Its Heterozygosity Suppresses Liver Tumorigenesis in Vivo

This study shows that the HNF4A Q164X mutation impairs transcriptional activity in vitro but reduces liver tumorigenesis in heterozygous mice.

Wnt7a is a Novel Lymphangiocrine Factor Driving Cholangiocyte Proliferation during Liver Regeneration

This study identifies Wnt7a as a lymphangiocrine factor that promotes cholangiocyte proliferation during liver regeneration in both rodent and human models.

HSD17B13 Couples Hepatocyte Lipid Metabolism to Stellate Cell Activation via TGFb-1 Signaling

This study identifies HSD17B13 as a dual metabolic and profibrotic effector that drives TGFb-1-dependent activation of hepatic stellate cells, linking lipid metabolism to fibrogenesis in MASH.

EGFR activation in cholangiocytes promotes extrahepatic bile duct regeneration after injury

This study shows EGFR activation in cholangiocytes drives extrahepatic bile duct regeneration after injury by promoting proliferation and altering ligand-receptor dynamics.

Pan-fibrotic gene expression signature in major chronic diseases by integrative bulk and single-cell transcriptomic analyses

The paper identifies a conserved pan-fibrotic gene expression signature across liver, kidney, and heart fibrosis using bulk and single-cell transcriptomic data.

A spatially localised cryoinjury model to study liver regeneration in zebrafish

This paper describes a cryoinjury model in zebrafish to study liver regeneration by inducing localized necrosis, inflammation, and fibrosis.

Modeling Fibrosis with MASH Patient Liver-Derived Organoids.

The paper develops a 3D MASH liver fibrosis model using patient-derived organoids and shows that YAP1 knockdown reduces fibrosis by inducing myofibroblast senescence.