Liver physiology and pathology

Acute Pericentral Liver Injury Induces a Novel Transient Hepatocyte Population

The paper identifies a novel transient SOX9+ pericentral hepatocyte population in acute liver injury that mediates early tissue repair and immune modulation.

Plasmin activity and sterile inflammation synergize to promote lethal embryonic liver degeneration

The paper shows that plasmin activity and sterile inflammation work together to cause lethal liver degeneration in embryos, and that reducing both improves liver health.

AI-assisted Drug Re-purposing for Human Liver Fibrosis

This study uses an AI co-scientist to identify and validate anti-fibrotic drugs in human hepatic organoids, finding that epigenomic modifiers play a key role in liver fibrosis.

The Circadian Clock Controls Hepatic Stellate Cell Activation in Liver Fibrosis via a BMAL1/CK1ϵ/REV-ERBα/Transgelin Signaling Pathway.

This study identifies a circadian clock-controlled signaling pathway that drives hepatic stellate cell activation in liver fibrosis, offering potential drug targets and a basis for chronotherapeutic strategies.

TGF-β serves as a critical signaling determinant of liver progenitor cell fate and function

This study identifies TGF-β as a key regulator of liver progenitor cell quiescence and activation, showing its dual role in inhibiting proliferation while being counteracted by HGF and EGF signals.

A Human Single-cell Atlas Identifies OLR1+ Scar-associated Macrophages as a Therapeutic Target for Chronic Liver Disease

SALL4 is required for YAP1-dependent malignant and regenerative hepatocyte reprogramming into cholangiocyte lineage

This study identifies SALL4 as a regulator of YAP1-driven hepatocyte-to-cholangiocyte reprogramming, showing its role in both malignant and regenerative liver processes.

The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis

This paper investigates 4-Methylumbelliferone's potential as a repurposed treatment for liver fibrosis, finding that it lacks efficacy at translatable doses and has an unclear mechanism.

The interplay between biomechanics and cell kinetics explains the spatial pattern in liver fibrosis

This paper develops a digital twin model to simulate liver fibrosis patterns, showing that ECM distribution results from cell death zones and biomechanical compression.

E cadherin appears to be an essential on/off switch for initiating bile canaliculi formation

The paper identifies E cadherin as essential for initiating bile canaliculi formation in hepatocytes through proteomic analysis and protein repression experiments.

Reproductive state controls transcription in the murine liver, with implications for breast cancer liver metastasis

This study examines liver transcriptional changes during lactation and weaning in mice, finding similarities between liver involution and pre-metastatic niches, with implications for breast cancer metastasis.

Primitive Hepatoblasts Driving Early Liver Development

The paper identifies and characterizes a new population of early hepatoblasts in mouse and human liver development, showing their role in liver bud formation and their decline in later stages.

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish

This study shows that cholangiocytes generate new hepatocytes during zebrafish liver regeneration after partial injury during growth.

Regulation of essential hepatocyte functions and identity by super-enhancers in health and disease

This study identifies super-enhancers as critical regulators of liver function genes in hepatocytes and liver progenitor cells during health and acute liver failure.

Amniotic Fluid Reduces Liver Fibrosis By Attenuating Hepatic Stellate Cell Activation

This study shows that cell-free amniotic fluid reduces liver fibrosis by inhibiting hepatic stellate cell activation in multiple models.

Tirzepatide reduces diet-induced senescence and NETosis-mediated liver fibrosis in mice

This study shows tirzepatide reduces diet-induced liver fibrosis by decreasing lipofuscin accumulation and NETosis in mice.

Purification protocol of hypertrophied hepatic stellate cells for their transcriptomic characterization from CDAHFD mice liver

The paper describes a protocol to purify hypertrophied hepatic stellate cells (hypHSCs) from CDAHFD mice and performs bulk RNA-seq to show their distinct molecular signature compared to quiescent HSCs.

EVALUATION OF STAINING FOR FIBRONECTIN ISOFORMS IN LIVER DISEASES

This study evaluates the distribution of fibronectin isoforms in liver diseases, finding they are present in hepatocytes and fibrotic bundles, contradicting the idea they are limited to fibrotic bundles.

HIV-1 Amplifies IL-8 Response Of Human Stellate Cells To Gram-Positive Microbial Products Via H4K5 Histone Acetylation

This study shows HIV-1 enhances IL-8 production in HSCs in response to LTA through histone H4K5 acetylation, contributing to liver fibrosis in HIV-positive individuals.

Two types of regeneration mechanism in acute liver injury

This study identifies two distinct cell proliferation populations during liver regeneration in mice with acute liver injury using single-cell RNA-seq.

A novel sorting method reveals superior metabolic activity of mononucleated over binucleated tetraploid hepatocytes

This study develops a flow cytometry method to distinguish mononucleated and binucleated tetraploid hepatocytes, revealing that mononucleated cells have more metabolically active gene expression.

Constitutive Androstane Receptor induces Ribonucleotide Reductase-M2 expression and maintains hepatocyte ploidy in mice

This study shows that CAR maintains hepatocyte ploidy by inducing RRM2 expression, which supports DNA synthesis and tetraploid hepatocyte formation in mice.

hESCs-derived organoids achieve liver zonation by LSEC modulation

This study creates zonated liver organoids using hESCs-derived hepatocytes and LSECs, showing that GLP-1RA targets LSECs to alleviate NAFLD.

Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states

The paper shows that gluconeogenic gene expression and activity in liver hepatocytes change spatially and temporally during feeding, fasting, and starvation states.

Tissue scarring provides a biomechanical framework to promote mammalian bile duct regeneration through the activation of integrin-SRC/FAK signalling.

This study shows that collagen scar formation during bile duct regeneration alters biomechanical properties, activating integrin-SRC/FAK signaling to drive ductular regeneration through a leading-tip of integrin-2-high cells.

Estrogen Receptor 1 Signaling in Hepatic Stellate Cells Designates Resistance to Liver Fibrosis

This study shows that estrogen receptor 1 in hepatic stellate cells influences liver fibrosis severity, with ESR1 deletion promoting fibrosis and estradiol reducing it in mice.

Spatial single-cell interactome and niche-specific molecular signatures in alcohol-related liver disease

The paper uses spatial transcriptomics and single-cell data to identify niche-specific molecular signatures and signaling pathways in ALD cirrhosis, highlighting potential therapeutic targets.

Temporal-spatially metabolic reprogramming rewires the H3K27ac landscape to enable the initiation of liver regeneration

This study identifies metabolic reprogramming and its impact on the H3K27ac epigenetic landscape during liver regeneration.

The transcription factor ZNF469 regulates collagen production in liver fibrosis

The paper identifies ZNF469 as a transcription factor regulating collagen production in liver fibrosis through computational analysis and experimental validation.

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumourigenesis

The paper identifies PROX1 as a safeguard repressor that maintains hepatocyte identity and prevents liver tumourigenesis by repressing alternate fate regulators.