S. Chen

INHBA/Activin A promotes tumor growth and induces resistance to anti-PD-L1 therapy by suppressing IFN-γ signaling

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Protein thiol alterations drive aberrant phase separation in aging

This study shows that aging-related changes in cysteine posttranslational modifications alter protein phase separation, leading to aggregation and neurodegeneration.

Alteration in Gut Microbiome and Intestinal Barrier Function caused by Efavirenz versus Dolutegravir Treatments in Mice

This study compares the effects of EFV and DTG on gut microbiome and intestinal barrier function in mice, finding both drugs impair gut barrier integrity, with EFV causing more severe metabolic and structural changes.

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

This study identifies breast cancer subtypes and their lineage origins by analyzing chromatin accessibility and transcriptional dynamics using multi-omic techniques.

A peptide-centric local stability assay to unveil protein targets of diverse ligands

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.

Upregulation of the NKG2D ligand ULBP2 by JC polyomavirus infection promotes immune recognition by natural killer cells.

This study shows that NK cells can eliminate JCPyV-infected cells through NKG2D-ULBP2 interaction, suggesting this pathway as a potential immunotherapeutic target for PML.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

Epigenetic coordination of transcriptional and translational programs in hypoxia

The paper shows hypoxia induces TSS switching via H3K4me3 changes, altering translation of key metabolic genes like PDK1.

Defining the SPCA2C interactome identifies unique links to store-operated calcium entry

This study identifies novel SPCA2C interactors involved in calcium signaling and vesicular transport using BioID and validates key interactions with STIM1, ESYT1, and CCDC47.

Genetically engineered mesenchymal stem cells as a nitric oxide reservoir for acute kidney injury therapy

This paper genetically engineers mesenchymal stem cells to act as a nitric oxide reservoir, enhancing therapeutic efficiency in acute kidney injury by precise spatiotemporal NO release.

Epigenetic Reshaping through Damage: Promoting Cell Fate Transition by BrdU and IdU Incorporation

The paper investigates how BrdU and IdU incorporation through DNA damage repair induces epigenetic changes that promote cell fate transition.

Metabolomics-assisted mechanism analysis of gamma-PGA synthesis regulated by PhoP in B. licheniformis

This study shows PhoP directly regulates {gamma}-PGA synthesis in B. licheniformis and indirectly affects it through glutamate transport, nitrogen utilization, and ammonia assimilation.

Frequency-dependent selection of neoantigens fosters tumor immune escape and predicts immunotherapy response

This study introduces negative frequency-dependent selection (NFDS) in tumors, showing it leads to immune evasion and poor response to immunotherapy, supported by whole-exome sequencing data.

High Volume Rate 3-D Ultrasound Imaging Using Fast-Tilting and Redirecting Reflectors

This paper introduces a new 3-D ultrasound imaging technique called FASTER that improves volume rate and usability compared to conventional methods.

Immunometabolic cues recompose and reprogram the microenvironment around biomaterials

The paper shows that immunometabolic cues around biomaterials influence immune cell trafficking and microenvironment composition, promoting a pro-regenerative state through metabolic reprogramming.

Single-molecule Imaging of SWI/SNF Chromatin Remodelers Reveal Multi-modal and Cancer-mutant-specific Landscape of DNA-binding Dynamics

This paper uses single-molecule imaging to analyze the dynamics of SWI/SNF chromatin remodelers in live cells, revealing mutant-specific changes in binding behavior linked to cancer.

Multi-omic study of genome-edited human colonoid models of colorectal cancer reveal genotype-specific patterns of microRNA regulation

This study uses genome-edited human colonoids to identify genotype-specific miRNA regulation patterns in colorectal cancer, highlighting potential therapeutic targets.

AMPK targets PDZD8 to trigger carbon source shift to glutamine

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

Eliminating Malaria Vectors with Precision Guided Sterile Males

This paper develops a precision guided Sterile Insect Technique (pgSIT) for malaria vector control using CRISPR to achieve high male sterility and female lethality in Anopheles gambiae.

Mutational analysis reveals a novel role for hepatitis C virus NS5A domain I in cyclophilin-dependent genome replication

This paper identifies a novel role for HCV NS5A domain I in cyclophilin-dependent genome replication, showing genotype-specific differences in Cyp interactions.

Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus

The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.

Structural basis of CMKLR1 signaling induced by chemerin9

The paper determines the cryo-EM structure of the CMKLR1-Gi complex with chemerin9, revealing molecular mechanisms of signaling and potential for small molecule agonist development.

Synergistic effects of multiple pesticides on the flight ability of honey bees (Apis cerana F.)

This study shows that combinations of imidacloprid, chlorpyrifos, and glyphosate synergistically reduce flight ability in honey bees, while individual pesticides do not.

The Structural Role of N170 in Substrate-assisted Deacylation in KPC-2 β-Lactamase

This study investigates the structural role of N170 in substrate-assisted deacylation in KPC-2 β-lactamase, revealing its impact on drug binding and catalytic activity.

FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis

This study identifies FAM210A as a regulator of mitochondrial translation and cardiac mitochondrial homeostasis, showing its deficiency leads to heart failure and its overexpression rescues cardiac function in ischemic heart disease.

Three-dimensional Shear Wave Elastography Using Acoustic Radiation Force and A 2-D Row-Column Addressing (RCA) Array

This paper introduces a 3-D shear wave elastography method using a 2-D row-column addressing array, demonstrating robust performance in both phantom and in vivo studies.

Co-engagement of TIGIT+ immune cells to PD-L1+ tumours by a bispecific antibody potentiates T-cell response and tumour control

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

Hypoxia-induced circSTT3A maintains Breast Cancer Stem Cell formation by Stabilizing PGK1 protein

This study identifies circSTT3A as a hypoxia-induced circular RNA that stabilizes PGK1 protein to promote breast cancer stem cell formation and chemotherapy resistance.

Assembly and Cation-selectivity Mechanisms of Neuronal Gap Junction Channel Connexin 36 Elucidated by Cryo-EM

This study determines the cryo-EM structure of Cx36, revealing structural features that explain its homomeric assembly and cation-selectivity, and provides insights into its role in electrical synapses.