Y. Lu

Autologous iPSC- and MSC-derived Chondrocyte Implants for Cartilage Repair in a Miniature Pig Model

This study compares autologous iPSC- and BMSC-derived chondrocyte implants in minipigs, finding iMSC-Ch implants produce more hyaline cartilage-like tissue.

Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy

This study investigates how cleavage of ZP2 in the egg zona pellucida leads to oligomerization and structural changes that block polyspermy.

PENet: A phenotype encoding network for automatic extraction and representation of morphological discriminative features

PENet is a deep learning model that automatically extracts and encodes morphological features into hash codes, showing effectiveness in feature extraction and image retrieval across beetle datasets.

SEL1L-HRD1 interaction is prerequisite for the formation of a functional HRD1 ERAD complex

This study shows that the SEL1L-HRD1 interaction is essential for HRD1 ERAD complex function, as its disruption leads to developmental defects and cerebellar ataxia in mice.

Clostridium butyricum and Clostridium tyrobutyricum: angle or devil for Necrotizing enterocolitis?

This study compares the effects of Clostridium butyricum and Clostridium tyrobutyricum on Necrotizing enterocolitis in mice, finding that C. tyrobutyricum alleviates inflammation and improves intestinal barrier integrity, while C. butyricum worsens these conditions.

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes

This study shows ANXA11 biomolecular condensates couple protein and lipid phase states on lysosomal membranes through interactions with ALG2 and CALC.

Modelling collagen fibril self-assembly from extracellular medium in embryonic tendon

The paper models collagen fibril self-assembly in embryonic mouse tendon, showing that fibrils form extracellularly through a phase-transition mechanism, supported by experimental data.

Single-Cell Map of Dynamic Multicellular Ecosystem of Radiation-Induced Intestinal Injury

This study maps the dynamic multicellular ecosystem of radiation-induced intestinal injury using single-cell RNA sequencing, revealing heterogeneous radiosensitivities and cellular interactions.

Rigosertib promotes anti-tumor immunity via autophagic degradation of PD-L1 in colorectal cancer cells

Rigosertib promotes anti-tumor immunity by inducing autophagic degradation of PD-L1 in colorectal cancer cells, enhancing immune response and synergizing with checkpoint inhibitors.

Two teosintes made modern maize

This study clarifies the origin of modern maize by showing it resulted from an ancient admixture between domesticated maize and Zea mays ssp. mexicana around 5300 years ago, contributing to genetic and phenotypic diversity.

High frequency soil polarization can phenotype crop roots noninvasively

This study shows that high-frequency soil polarization (ECsoil) can accurately measure root volume and distribution in the field, with potential for noninvasive root phenotyping.

Single-cell transcriptional analysis of lamina propria lymphocytes in the jejunum reveals ILC-like cells in pigs

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

Recurrent evolution of small body size and loss of the sword ornament in Northern Swordtail fish

The paper uses whole-genome sequencing to resolve phylogenetic relationships in Xiphophorus fish, revealing recurrent loss of sexually selected traits like body size and sword ornaments.

Cellular and Fibrillar Collagen Analyses in an Animal Model of Retinal Detachment-Related Proliferative Vitreoretinopathy Reveals a Defined Transition to Chronic Fibrosis

This study uses a rabbit model of retinal detachment to analyze cellular and fibrillar collagen changes, revealing a transition to chronic fibrosis in PVR.

Target Recycling Amplification Process for Digital Detection of Exosomal MicroRNAs Through Photonic Resonator Absorption Microscopy

This paper introduces TRAP, a method for detecting exosomal miRNAs with high sensitivity and selectivity, showing improved detection limits compared to qRT-PCR.

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.

First superferromagnetic remanence characterization and scan optimization for super-resolution Magnetic Particle Imaging

This paper characterizes superferromagnetic remanence in nanoparticles and optimizes MPI scanning for improved resolution and signal.

Structural Insights into Branch Site Proofreading by Human Spliceosome

The paper reports atomic structures of human spliceosome complexes to elucidate PRP5's role in branch site proofreading during pre-mRNA splicing.

IRE-1α is a key switch of pyroptosis and necroptosis in mice by dominating Gasdermin D

This study shows IRE-1α regulates both necroptosis and pyroptosis in mice by modulating GSDMD activity, with implications for therapeutic targeting in tissue injuries.

Evolution of m6A related genes in insects and function of METTL3 in embryonic development of silkworm.

This study investigates the evolutionary conservation of m6A-related genes in insects and identifies METTL3's role in silkworm embryonic development through functional analysis.

Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

Multiple omic investigations of freeze tolerance adaptation in the aquatic ectothermic vertebrate, the Amur sleeper

The paper investigates freeze tolerance in the Amur sleeper using genomic, transcriptomic, and metabolomic analyses to identify genetic and molecular mechanisms underlying this adaptation.

Cardiac patch treatment alleviates ischemic cardiomyopathy correlated with reverting Piezo1/2 expression by unloading left ventricular myocardium

This study shows cardiac patches reduce ischemic cardiomyopathy by lowering mechanical load and reverting Piezo1/2 expression in the left ventricle.

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-associated Excitable Cells

The paper introduces the Swarm, a high-throughput optogenetic platform for screening ion channel modulators in excitable cells, demonstrating its utility in drug discovery for nervous system disorders and cardiac toxicity.

Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts

This study shows that Mmp14 regulates circadian rhythms and matrisome homeostasis in tendon fibroblasts by controlling collagen fibril synthesis and crosslinking.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

This study uses CRISPR screens to identify factors regulating wild-type and mutant p53 stability, finding distinct regulators for different p53 mutants and their implications in cancer.

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

The paper uses in vivo CRISPR screens to identify Serpinb9 and Adam2 as genes regulating immune therapy response in lung cancer, showing their roles in immune suppression and enhancement.

Peritoneal M2 macrophage-derived extracellular vesicles as natural multi-target nanotherapeutics to attenuate cytokine storm after severe infections

This study shows that M2 macrophage-derived extracellular vesicles reduce cytokine storm by targeting multiple pathways and can act as nanodecoys against SARS-CoV-2.