Tuberculosis Research and Epidemiology

Replication-deficient Adenovirus 5 Serotypes Induce Type I Interferon and enhance BCG-mediated Immune Response in Co-infected Murine Macrophages

This study investigates how co-infection with replication-deficient adenovirus and BCG in murine macrophages affects type I interferon signaling and host-protective gene expression, showing additive immune responses despite BCG suppression of IFN induction.

Reference-free clustering as an epidemiological tool for Mycobacterium tuberculosis lineage typing

This study evaluates reference-free methods for Mycobacterium tuberculosis lineage typing using simulated Illumina data, finding SKA2 to be the most accurate tool for strain classification.

Immune signatures of protection and progression in the airways of recent human tuberculosis household contacts

The paper identifies immune signatures in TB contacts that predict protection or progression to active TB using single-cell RNA sequencing and correlates findings with non-human primate data.

Genetic interference of distinctive Mycobacterium tuberculosis peptidoglycan modifications enhances β-lactam susceptibility and reveals expression-sensitive host immune dynamics

This study uses CRISPRi to silence Mtb genes involved in peptidoglycan modifications, showing their role in β-lactam resistance and host immune responses.

Next Generation TB Drug Combinations from the Pan-TB Consortium: Combination Efficacy and Contributions of Individual Agents, Evaluated in a BALB/c Mouse TB Model

The paper evaluates next-generation TB drug combinations in a mouse model, showing some regimens cure 90% of mice in under 2 months with faster sterilizing efficacy than existing treatments.

A Type VII-secreted toxin enables inter-mycobacterial competition

The paper identifies a type VII-secreted toxin in mycobacteria that enables inter-bacterial competition by targeting arabinogalactan.

Human CD1c-autoreactive T cells recognise Mycobacterium tuberculosis-infected antigen-presenting cells and display cytotoxic effector programmes

This study shows CD1c-autoreactive T-cells recognize Mtb-infected APCs, exhibit cytotoxicity, and reduce Mtb burden through CD1c-dependent mechanisms.

Conserved T cell receptor usage underpins recognition of CD1c presenting a mycobacterial lipid

The paper identifies a conserved TCR motif recognizing mycobacterial lipids presented by CD1c, showing higher frequencies in TB-endemic regions and providing a cryo-EM structure of the interaction.

HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing of Irgm1

This study identifies hnRNPA2B1 as a splicing regulator that modulates anti-mycobacterial immune responses in macrophages by controlling alternative splicing of Irgm1.

Modeling development of tertiary lymphoid structures in pulmonary tuberculosis by 3D profiling and trajectory analysis

This study uses 3D reconstruction and optimal transport modeling to analyze TLS development in TB-infected lungs, revealing distinct maturation trajectories and spatial dynamics.

Enhanced respiratory electron dissipation by immunometabolites promotes mycobacterial biofilm longevity

This study shows that immunometabolites like nitrate or fumarate extend mycobacterial biofilm lifespan by suppressing dormancy and maintaining metabolic activity.

Induced alanine auxotrophy as a therapeutic strategy against Mycobacterium tuberculosis

The paper identifies TI-374 and TI-801 as inhibitors of Mycobacterium tuberculosis's AlaA enzyme, showing their efficacy against intracellular Mtb and supporting AlaA as a therapeutic target.

Immortal genome assumption significantly underestimates replication and death rates of Mycobacterium tuberculosis in mice and monkeys

The paper challenges the assumption that Mtb DNA decay rates reflect bacterial death rates, showing that Mtb replication and death rates are still significant even with slow DNA decay.

Gonadal regulation of sex-specific immunity in tuberculosis: enhanced lymphocyte function in females and dysfunctional myeloid responses in males

This study shows that gonadal sex, not chromosomal sex, influences TB susceptibility in mice, with males showing myeloid dysfunction and females showing enhanced immune responses.

mRNA-based tuberculosis vaccines BNT164a1 and BNT164b1 are immunogenic, well-tolerated and efficacious in rodent models

This paper describes two mRNA vaccines for tuberculosis that are immunogenic, well-tolerated, and effective in rodent models, entering clinical trials.

VadK, a Non-Canonical Kinase that Regulates the Methylcitrate Cycle and is Essential for Mycobacterium tuberculosis Virulence

Rv3839-Rv3840 links the endogenous heme biosynthesis pathway with Mycobacterium tuberculosis adaptation to nitric oxide and iron limitation stress

This study identifies Rv3839-Rv3840 as key regulators linking heme biosynthesis with Mtb adaptation to NO and iron limitation stress.

Exploiting NDH-2 Vulnerability: Quinolines as Antitubercular Agents

This study identifies quinoline derivatives as antitubercular agents targeting NDH-2, showing efficacy against multidrug-resistant Mycobacterium tuberculosis.

Characterization of programmed cell death pathways activated in Mycobacterium tuberculosis-infected human macrophages

This study identifies that Mtb-infected macrophages undergo cell death without canonical pathways, correlating with DNA release similar to NETosis.

Natural product-based putative efflux inhibitors restore bedaquiline susceptibility in a drug-resistant Mycobacterium tuberculosis mutant

This study identifies natural product-derived efflux inhibitors that restore bedaquiline susceptibility in drug-resistant Mycobacterium tuberculosis mutants.

Inorganic sulfate transport by the Mycobacterium tuberculosis PE22/PPE36 complex

This study identifies the PE22/PPE36 complex in Mycobacterium tuberculosis as a sulfate uptake system, showing its role in sulfur acquisition and metabolic homeostasis.

Galectin-3 recruitment at the Mycobacterium tuberculosis-containing phagosome is critical in macrophage but dispensable in epithelial cells

This study shows that Galectin-3 recruitment to Mtb-containing vacuoles is essential in macrophages but not in epithelial cells, highlighting its role in restricting bacterial growth.

Modulation of Ferroptosis During Early Mycobacterium tuberculosis Infection Contributes to Beijing Lineage Strain SA161 Virulence

This study shows that ferroptosis, a form of cell death, is enhanced by a virulent Mtb strain, SA161, and inhibiting it reduces bacterial spread in mice.

A genetically encoded biosensor reveals heterogenous cAMP dynamics coordinating growth and resuscitation in Mycobacterium tuberculosis

This paper develops a genetically encoded biosensor, rmgCarvi, to monitor cAMP dynamics in Mycobacterium tuberculosis at single-cell resolution, revealing how cAMP levels coordinate growth and resuscitation in response to nutrient availability and host environments.

Discovery of ARQ-501 as a potent PafA inhibitor that elevates KatG levels to potentiate isoniazid in mycobacteria

The paper identifies ARQ-501 as a PafA inhibitor that increases KatG levels, enhancing isoniazid efficacy against tuberculosis.

Type I interferon-driven lung pathology restricts T cell accumulation and motility during tuberculosis

This study shows that type I interferon signaling in tuberculosis restricts T cell accumulation and motility by altering lung pathology and T cell states.

Disease progression is associated with differential neutrophil maturation in Mycobacterium tuberculosis-infected macaques

This study identifies transcriptomic and phenotypic changes in neutrophils associated with disease progression in Mtb-infected macaques.

A new Persister Enrichment Model in Mycobacterium tuberculosis links multidrug persistence to drug sequencing and maltokinase-dependent carbon distribution.

This paper introduces a Persister Enrichment Model (PEM) to study multidrug persistence in M. tuberculosis, showing that drug sequencing and maltokinase-dependent carbon distribution influence antibiotic tolerance.

Mycobacteriophage D29-Derived LysB Enhances Anti-Tubercular Therapy in Experimental Pulmonary Tuberculosis

This study shows that intranasal administration of D29 LysB enhances the effectiveness of standard antitubercular therapy in murine and guinea pig models of tuberculosis by reducing bacterial load and improving tissue pathology.

Sorting endosomes play key roles in presentation of Mycobacterium tuberculosis-derived ligands to MAIT cells

The paper identifies sorting endosomes as critical for MR1 antigen presentation of Mycobacterium tuberculosis-derived ligands to MAIT cells, highlighting the roles of Syntaxin 12 and 16 in this process.