Cancer-related molecular mechanisms research

CRISPR-inhibition screen for lncRNAs linked to melanoma growth and metastasis

The paper identifies lncRNAs involved in melanoma growth and metastasis using CRISPR-inhibition screens and validates their functional roles.

Transitional lncRNA Signatures Reveal Distinct Stages of Cancer Progression and Metastasis

This study identifies transitional lncRNAs (Tr-lncRNAs) associated with cancer progression stages and metastasis using TCGA data, revealing cancer-type specific and shared lncRNA signatures.

Regulatory elements of pancreas development license the initiation of pancreatic ductal adenocarcinoma

This study identifies LINC00673, a long noncoding RNA from a Sox9-associated super-enhancer, as critical for pancreatic regeneration and PDAC initiation by regulating cell-autonomous and non-cell-autonomous processes.

NeuID, a novel neuron-specific lncRNA, resolved a key epigenetic mechanisms linking gene silencing to Alzheimer's disease

The paper identifies NeuID, a novel neuron-specific lncRNA downregulated in Alzheimer's disease, as a key regulator of neuronal identity and a therapeutic target.

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions between Non-Coding RNAs in Cancer Cells

This study introduces a dual CRISPRi system to target lncRNAs in melanoma cells, enabling synthetic lethal screening to identify cancer-specific lncRNA interactions for therapeutic strategies.

Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression

The paper shows that ASOs targeting CHASERR induce fusion transcripts that increase CHD2 expression, alleviating haploinsufficiency in mice.

In vivo CRISPRi screen identified lncRNA portfolio crucial for cutaneous squamous cell carcinoma tumor growth

The paper identifies lncRNAs crucial for cSCC tumor growth using CRISPRi screens and single-cell sequencing.

POCALI: Prediction and insight On CAncer LncRNAs by Integrating multi-omics data with machine learning

POCALI identifies cancer lncRNAs by integrating 44 multi-omics features, showing improved sensitivity and strong associations with cancer phenotypes.

Xist Repeat A coordinates an assembly of SR proteins to recruit SPEN and induce gene silencing

The paper identifies how Xist Repeat A recruits SPEN via SR proteins to induce gene silencing, revealing a role for splicing factors in this process.

Identification and Characterization of PCAHIT, a Novel Long Non-Coding RNA Associated with Poor Outcomes in Prostate Cancer

This study identifies PCAHIT, a lncRNA linked to poor outcomes in prostate cancer, showing it promotes aggressive phenotypes by affecting steroid biosynthesis and immune response.

A trans-acting enhancer lncRNA modulates androgen-dependent gene expression via sequence-specific interaction with the Androgen Receptor

This paper identifies an enhancer lncRNA that interacts with the Androgen Receptor to regulate gene expression and inhibit prostate cancer cell proliferation.

Two long non-coding RNAs, SVALKA and SVALNA, regulate CBF1 and CBF3 via multiple mechanisms

This study identifies two lncRNAs, SVALKA and SVALNA, that regulate CBF1 and CBF3 gene expression in Arabidopsis under cold stress through distinct mechanisms involving RNAPII collision and chromatin remodeling.

Identification and In Silico Characterization of Novel lncRNAs Associated with Dengue Infection

The paper identifies 65 novel lncRNAs differentially expressed in dengue infection and characterizes their potential regulatory roles through bioinformatics analysis.

CRISPRi Screen Uncovers lncRNA Regulators of Human Monocyte Growth

The paper uses a CRISPRi screen to identify lncRNAs critical for human monocyte viability, finding two lncRNAs that regulate proliferation and cell cycle genes.

Transcriptional stochasticity reveals multiple mechanisms of long noncoding RNA regulation at the Xist - Tsix locus

The paper investigates how transcriptional stochasticity influences the regulation of Xist and Tsix at the XCI locus through different mechanisms based on nascent transcription levels.

A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-κB and tumor cell phenotypes

The paper identifies a 36-base hairpin in lncRNA DRAIC that interacts with IKKα's coiled-coil domain, inhibits NF-κB activity, and suppresses tumor phenotypes through alternative splicing regulation.

eRNAkit: Expanding the Functional Atlas of human Enhancer RNAs Beyond the Nucleus

eRNAkit integrates subcellular localization, RNA-RNA interaction, and expression data for eRNAs to explore their non-nuclear functions beyond traditional cis-regulatory roles.

SNHG10 promote tumorigenesis via miR-150/VEGFA/EGFR/AKT/ERK/mTOR axis and gemcitabine resistance in PDAC

Role of lncRNAs related to NRs in the regulation of gene expression

The paper identifies six novel sequence motifs in lncRNAs that interact with multiple nuclear receptors and miRNAs, suggesting their role in gene regulation and evolutionary conservation.

A bifunctional imprinted lncRNA scaffolds NuRD-HDAC1 to couple cis-activation of Dio3 with trans-repression of the osteoblast chromatin landscape

The paper shows Dio3os scaffolds NuRD-HDAC1 to activate Dio3 in cis and repress thyroid-hormone-responsive osteogenic genes in trans.

Inferring non-coding RNA regulatory network from transcriptomic data and curated databases

The paper introduces CAR-NET, a framework for inferring non-coding RNA regulatory networks using transcriptomic data and curated databases, showing its effectiveness in simulations and case studies.

Unexpected XIST Expression in Male Hearts Associates with Disease

The paper reports endogenous XIST expression in male heart samples across multiple single-cell RNA sequencing studies and links it to heart disease and myocardial infarction.

EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs

The paper shows that ecDNA-borne PVT1 fusions stabilize oncogenic mRNAs by interacting with SRSF1, enhancing RNA stability and supporting MYC dependency in cancer.

An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation

The paper identifies an ultraconserved snoRNA-like element in the lncRNA CRNDE that promotes ribosome biogenesis and cell proliferation in renal cell carcinoma.

Identification of lncRNAs differentially expressed in Alzheimer's disease brains using RNA sequencing

The paper identifies differentially expressed lncRNAs in Alzheimer's disease brains using RNA-seq data from multiple studies and brain regions.

A therapeutic role for a regulatory glucose transporter1 (Glut1)-associated natural antisense transcript

This paper identifies a natural antisense transcript that regulates Glut1 expression and demonstrates its therapeutic potential in Glut1 deficiency syndrome.

X-Linked Cancer-Associated Polypeptide (XCP) from lncRNA1456 Cooperates with PHF8 to Regulate Gene Expression and Cellular Pathways in Breast Cancer

This study identifies XCP, a protein from the lncRNA1456, which interacts with PHF8 to regulate gene expression and cancer pathways in breast cancer.

The positionally conserved long non-coding RNA DANCR is an essential regulator of zebrafish development and a human melanoma oncogene

This study identifies DANCR as a conserved lncRNA essential for zebrafish development and a human melanoma oncogene, showing its role in regulating gene expression and promoting cancer progression.

LINC01503-MP is a Mitochondrial Microprotein That Promotes Cell Proliferation and Oxidative Metabolism.

This study identifies LINC01503-MP, a mitochondrial microprotein derived from an lncRNA, which promotes cell proliferation and oxidative metabolism in colorectal cancer cells.

Inhibition of TFIIH translocase reveals a novel lncRNA regulatory network at the BRCA1 locus

The paper identifies a novel lncRNA regulatory network at the BRCA1 locus that is activated during transcriptional stress induced by XPB inhibition.