Autophagy in Disease and Therapy

cAMP promotes acute lysosome biogenesis through TFEB nuclear import-export dynamics.

This study shows cAMP signaling regulates TFEB nuclear import and export, dynamically controlling lysosomal gene expression through PKA-dependent phosphorylation.

Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity

The paper shows that inhibiting autophagy in intestinal stem cells increases enteroendocrine cell differentiation via Stat92E activity in Drosophila.

Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate

A HaloTagged MFN2 reporter enabled CRISPRi screens showing diverse mitochondrial damage activates PINK1-Parkin via membrane potential loss, with TOM retaining PINK1 when TIM23 is blocked.

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

This study shows SIRT4 promotes autophagy by modulating ULK1 phosphorylation, independent of HDAC6 and OPA1, and identifies its role in early autophagy initiation.

A Reversible Mitochondrial ROS Probe for Monitoring Mitophagy Dynamics: Development and Application of MitoFlare

The paper introduces MitoFlare, a reversible mitochondrial ROS probe, and demonstrates its application in quantifying mitophagy dynamics in real time using a dual-probe imaging platform.

Autolamellasomes: Linking Autophagy-Dependent ER Degradation to Whorled Lysosome Biogenesis

The paper identifies autolamellasomes as a form of ER remodeling mediating bulk ER degradation under mTOR inhibition, linking it to lysosomal membrane homeostasis and aging.

Pathway and gates for ATG2A-mediated lipid transport in autophagy

This study identifies the mechanism of ATG2A-mediated lipid transport in autophagy, revealing N-terminal helices as gates that regulate lipid transfer efficiency.

Screening for residues in Atg11, a central organizer of selective autophagy in yeast, important for binding with Atg9

The paper screens Atg11 residues in yeast to identify binding sites for Atg9 during selective autophagy but fails to find specific essential residues.

Autophagy is dispensable in germline stem cells but is required in the cap cells for their maintenance in the Drosophila ovarian niche

CREG1 promotes autophagy and protects the heart against nutritional stress-induced injury and age-associated hypertrophy, fibrosis and diastolic dysfunction

This study shows that CREG1 promotes autophagy and protects the heart from nutritional stress and age-related damage by maintaining autophagic flux and preventing mitochondrial dysfunction.

Endosomal Microautophagy is Activated by Specific Cellular Stresses in Trout Hepatocytes

The paper identifies endosomal microautophagy (eMI) activation in trout hepatocytes under specific stress conditions and suggests its compensatory role when CMA is impaired.

Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance

This study identifies ERC1 as a protein that forms biomolecular condensates to recruit ATG8 and NBR1, promoting autophagosome formation and enhancing heat tolerance in Arabidopsis.

A structural and regulatory framework for Atg9-containing vesicle formation and their Atg1-dependent remodelling during autophagy initiation

BCHS acts as a stress transducer connecting autophagic quality control with DNA damage repair

This study shows that BCHS connects autophagy with DNA repair by regulating nuclear proteostasis and extracellular signaling in Drosophila.

E3 ubiquitin ligase SKP2 limits autophagy during S. aureus infection

This study shows that SKP2 limits autophagy during S. aureus infection by stabilizing and translocating to the cytoplasm, reducing LC3-II levels and intracellular bacterial survival.

Exercise training improves sarcopenic muscle function via restoration of mitochondrial quality control

This study shows that exercise training restores mitochondrial quality control in sarcopenic muscle by improving mitophagy, mitochondrial respiration, and muscle strength.

Chemerin-CMKLR1 mediated OGD/R induced Mitochondrial Dysfunction, Oxidative Stress, and Autophagy differentially in Microglia and Neurons

This study investigates how chemerin-CMKLR1 signaling differentially affects mitochondrial dysfunction, oxidative stress, and autophagy in microglia and neurons under OGD/R conditions.

Regulation of macroautophagy and microautophagic lipophagy by phosphatidylserine synthase Cho1 and external ethanolamine

This study investigates the role of Cho1-encoded phosphatidylserine synthase in autophagy, showing its essential role in macroautophagy and its interaction with the ubiquitination system in microautophagic lipophagy.

The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions

The paper identifies Rab7-Epg5 and Rab39-ema modules that coordinate autophagosome positioning toward the ncMTOC for efficient lysosomal fusion in Drosophila fat cells.

Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling

This study shows that autophagy in adipocytes limits obesity-related fibrosis by controlling purine nucleoside metabolism and macrophage polarization.

A dosage-sensitive ALLO-1 network coordinates mitochondrial quality control to enable functional recovery of structurally compromised muscle

The paper identifies an ALLO-1 network that coordinates mitochondrial quality control in C. elegans muscle, enabling functional recovery despite structural damage.

ULK1/2 Inhibitors that Degrade ATG13 Effectively Target KRAS-Mutant Cancers

The paper identifies SBP-1750, a ULK inhibitor that degrades ATG13 and kills KRAS-mutant cancer cells, showing efficacy in vivo and immune enhancement.

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy

This study shows TRAF6 regulates glucose homeostasis via mitophagy in islets, with both Parkin-dependent and -independent pathways involved.

Mitochondrial Dysfunction alters Early Endosome Distribution and Cargo Trafficking via ROS-Mediated Microtubule Reorganization

This study shows mitochondrial dysfunction causes early endosome aggregation and cargo trafficking defects via ROS-induced microtubule reorganization, highlighting mitochondria's role in endocytic trafficking.

Sequelae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons

This study investigates age-related changes in mitochondrial dynamics and autophagy in reprogrammed human neurons, finding that autophagy enhancement can reverse these age-dependent alterations.

TFEB/HLH-30-mediated expansion of neuronal lysosomal capacity in early adulthood protects dendrite maintenance during aging in Caenorhabditis elegans

This study shows that HLH-30/TFEB expands neuronal lysosomal capacity in early adulthood, protecting dendrite maintenance during aging in C. elegans.

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues

This study identifies glycophagy dysregulation as a mechanism of diabetic heart disease and shows that Gabarapl1 gene therapy improves cardiac function in diabetic mice and human cardiac organoids.

Pneumolysin-dependent and independent non-canonical autophagy processes mediate host defense against pneumococcal infection

This study identifies non-canonical autophagy pathways, including LC3-associated phagocytosis and STIL, that mediate host defense against pneumococcal infection in zebrafish.

Amphisome biogenesis couples synaptic autophagy to local protein synthesis

The paper shows that amphisomes formed at presynaptic boutons during sustained synaptic activity facilitate protein degradation and local replenishment through mRNA translation.

Activity-dependent coupling of axonal amphisome trafficking and local norepinephrine signaling in vivo

This study shows that axonal amphisome trafficking in locus coeruleus neurons is regulated by norepinephrine signaling and neuronal activity, with implications for proteostasis.