Ion Channels and Receptors

TRPV4-mediated Mechanotransduction Regulates the Differentiation of Valvular Interstitial Cells to Myofibroblasts: Implications for Aortic Stenosis

This study shows that TRPV4 channels regulate valvular interstitial cell-to-myofibroblast differentiation in aortic stenosis by modulating mechanotransduction and PI3K-AKT signaling.

Localization of AP2α2, TRPV1 and PIEZO2 to the Large Dense Core Vesicles of Human Dorsal Root Ganglion Neurons

A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation

The paper identifies PIEZO2 as a key mechanosensitive ion channel in adipose sensory innervation and shows its role in regulating adipose tissue phenotypes.

Thermal and mechanical modalities converge in the noxious range

The paper investigates how sensory fibers encode thermal and mechanical nociceptive input in mice, finding that modality separation dominates in the innocuous range while polymodality predominates in the noxious range.

A Single Mutation in TRPC6 Protects Mice from Acute Lung Injury by Regenerating Endothelium

This study identifies a TRPC6 mutation that protects mice from acute lung injury by promoting endothelial regeneration and preventing vascular injury.

TRPV4 Dominates High Shear-Induced Initial Traction Response and Long-Term Relaxation Over Piezo1

This study identifies TRPV4 as the dominant mechanosensor for shear-induced traction responses in endothelial cells, surpassing Piezo1 in both initial traction rise and long-term relaxation.

Swimming motions evoke Ca2+ events in vascular endothelial cells of larval zebrafish via mechanical activation of Piezo1

This study shows that swimming motions in larval zebrafish trigger Ca2+ events in vascular endothelial cells through mechanical activation of Piezo1, independent of neural activity or blood flow.

An Evolutionary Novelty in TRPV1 Functional Regulation: Characterization of a Dominant-Negative Isoform Exclusive to Catarrhine Primates

The paper identifies a dominant-negative TRPV1 splice variant unique to catarrhine primates, which inhibits canonical TRPV1 function by preventing its membrane localization.

Convergent Agonist and Heat Activation of Nociceptor TRPM3

This study characterizes TRPM3 activation by chemical agonists and heat, revealing a shared mechanism involving intracellular domain rearrangements.

Mitochondria-ER contacts restrain store-operated Ca{superscript 2}⁺ entry via Ca{superscript 2}⁺ flickering and STIM1 trapping

This study shows that mitochondria-ER contacts inhibit store-operated Ca²⁺ entry by trapping STIM1 through Ca²⁺ flickering and microdomain formation.

The mechanosensory DEG/ENaC channel DEGT-1 is a proprioceptor of C. elegans foregut movement

This study identifies DEGT-1 as a mechanosensory ion channel in C. elegans that modulates pharyngeal pumping by detecting proprioceptive feedback from organ movement.

Protein Dynamics Underlies Strong Temperature Dependence of Heat Receptors

The paper shows that temperature sensing in TRPV1 channels is linked to protein unfolding and thermal instability, not conventional allosteric mechanisms.

Activity-Dependent Localization and Heterogeneous Dynamics of STIM1 and STIM2 at ER-PM contacts in Hippocampal Neurons.

The paper investigates the dynamic localization and activity-dependent behavior of STIM1 and STIM2 at ER-PM contacts in hippocampal neurons, revealing their heterogeneous dynamics and differential recruitment under different conditions.

Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

The paper identifies periodic ER-PM junctions in dendrites that enable long-range Ca2+ signal integration through local spine activation and ryanodine receptor-dependent Ca2+ release.

Molecular Insights into Single Chain Lipid Modulation of Acid-Sensing Ion Channel 3

This study investigates how PUFAs modulate ASIC3 channel activity by preventing phospholipid blockage of the pore using electrophysiology and molecular dynamics simulations.

Bidirectionally responsive thermoreceptors encode cool and warm

The paper identifies bidirectional thermoreceptors in mice that respond to both cool and warm temperatures, revealing their role in encoding innocuous thermal sensations.

OPN5 and TRPV4 subserve intrinsic photosensitivity in mouse corneal epithelium

The paper investigates UVB-induced calcium signaling in mouse corneal epithelial cells, identifying OPN5 and TRPV4 as key components of an intrinsic photosensitive pathway that triggers cytokine release and inflammatory responses.

Calcium dynamics of skin-resident macrophages during homeostasis and tissue injury

This study examines calcium dynamics in Langerhans cells during homeostasis and tissue injury, showing context-specific changes and their role in engulfment of keratinocyte debris.

ER Ca2+-levels control neuromodulator secretion by regulating L-type Ca2+-channel activity via its STIM1-interacting domain

The paper shows that ER Ca2+ depletion in mouse neurons reduces DCV exocytosis by inhibiting L-type Ca2+ channels via a STIM1-dependent feedback loop, while not affecting SV exocytosis.

The Cryo-EM structure of TRPC1 and TRPC5 heterotetramer

The paper reports the cryo-EM structure of TRPC1/5 heterotetramer, revealing structural features that differentiate it from TRPC5 homomers and provide insights into its functional properties.

Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics

The paper engineers hTRPV4 to create an ultrasound-sensitive actuator for sonogenetics, showing improved mechano-sensitivity and reduced sensitivity to other stimuli.

TRPM8 channels control Golgi morphology through an AR-dependent induction of the Scd1 gene and modulation of unsaturated lipid content

This study shows TRPM8 controls Golgi morphology by regulating Scd1 gene expression and lipid content via the androgen receptor.

Spinal cerebrospinal fluid contacting neurons are a conserved sensory neuronal population along the mouse spinal cord

The paper identifies and characterizes a conserved population of spinal cerebrospinal fluid contacting neurons in mice, revealing their sensory functions and receptor expression.

TENM4 is an essential transduction component for touch

This study identifies TENM4 as an essential extracellular linker protein for mechanotransduction in mechanoreceptors, showing its role in touch sensitivity.

Regulating Human T Lymphocytes Through Magnetogenetic Tools

This study investigates magnetogenetic tools to regulate T cell activity, finding they enhance activation with antigen stimulation but deactivate cells without it.

Mechanisms underlying TRPV4-mediated regulation of miR-146a expression

This study identifies how TRPV4 negatively regulates miR-146a expression in macrophages through histone deacetylation, independent of NFκB, Stat1, P38, and AKT pathways, in the context of inflammation and atherosclerosis.

Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction

This study shows cell crowding promotes invasion in high-grade DCIS by reducing cell volume through TRPV4 inhibition and mechanotransduction.

Re-evaluation of some popular CRAC channel inhibitors structurally similar but mechanistically different?

This study uses electrophysiology and in silico modeling to propose binding sites and modes of action for four CRAC channel inhibitors.

A human mitochondrial isoform of TRPV1 regulates intracellular Ca2+ simultaneously with mitochondrial thermolysis

The paper identifies a mitochondrial TRPV1 isoform, mitoTRPV1, which regulates intracellular Ca2+ and mitochondrial temperature without affecting respiration.

Pro-inflammatory mediators sensitise Transient Receptor Potential Melastatin 3 cation channel (TRPM3) signalling in mouse sensory neurons

This study investigates how inflammatory mediators affect TRPM3 channel function in mouse sensory neurons and finds that IL-1β and TNF potentiate TRPM3 without changing its expression, while pharmacological blockade does not alleviate inflammatory pain in a specific model.