D. Yang

Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction

The paper identifies targeted therapies that enhance lung cancer vulnerability to macrophage attack when combined with anti-CD47 antibodies, showing synergy across multiple genetic mutations.

Microbiome induced complement synthesized in the gut protects against enteric infections

The paper shows gut microbiota regulate complement component 3 (C3) production in humans and mice, with intestinal C3 levels correlating with protection against enteric infections.

An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment

This paper identifies LXY18, a 4-phenoxy-quinoline compound that blocks AURKB relocalization, showing potent antimitotic activity and oral bioavailability.

Multi-omics Comparison among Populations of Three Plant Sources of Amomi Fructus

This study compares multi-omics data across three plant sources of Amomi Fructus to identify genetic and transcriptomic differences, including gene flow and metabolic variation between populations.

A pilot study of stable isotope fractionation in Bombyx mori rearing

This study measures stable isotope fractionation in Bombyx mori strains across life stages to trace isotope movement and understand fractionation patterns.

Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity

This study designs and evaluates indoline-based CD4-mimetic compounds that inhibit HIV-1 more potently and broadly than existing indane-based compounds and sensitize HIV-1 to antibody-dependent cellular cytotoxicity.

Analysis of gene expression heterogeneity reveals therapeutic targets and novel regulators of metastasis

The paper identifies therapeutic targets and novel metastasis regulators by analyzing gene expression heterogeneity in triple-negative breast cancer using single-cell RNA sequencing.

Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1

The paper reports cryo-EM structures of PTH1R bound to PTH and PTHrP, revealing molecular mechanisms of hormone recognition and selectivity.

ZNF251 haploinsufficiency confers PARP inhibitors resistance in BRCA1-mutated cancer cells through activation of homologous recombination

This study identifies ZNF251 haploinsufficiency as a mechanism conferring PARP inhibitor resistance in BRCA1-mutated cancer cells through RAD51-mediated homologous recombination.

Targeting intracellular Neu1 for Coronavirus Infection Treatment

This study identifies Neu1 as a therapeutic target for coronavirus infection by showing its role in sialylation of viral proteins and demonstrates that a Neu1 inhibitor reduces viral replication in vitro and in vivo.

Activation of ERK by altered RNA splicing in cancer

The paper shows that SMNDC1, an upregulated splicing factor in cancer, promotes tumor growth by enhancing ERK1 kinase activity through altered RNA splicing of exon 4.

Study of the anti-inflammatory and anti-apoptosis effect of the traditional Mongolian Hohgardi-9 in acute lung injury

This study identifies active components of Hohgardi-9 and their mechanisms in treating acute lung injury by targeting inflammatory pathways and reducing apoptosis.

A self-blinking DNA probe for 3D superresolution imaging of native chromatin

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

Rapid and Live-cell Detection of Senescence in Mesenchymal Stem Cells by Micro Magnetic Resonance Relaxometry

This study develops a live-cell method to detect senescence in mesenchymal stem cells using micro magnetic resonance relaxometry, showing strong correlation with senescent markers.

A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge Of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8

This study shows that cardiac-specific overexpression of AC8 in mice leads to adaptive cardiac changes resembling cancer-like survival mechanisms without heart failure.

Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron-BA.2

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbits

This study shows that IDOL deficiency reduces atherosclerosis in rabbits fed a high-cholesterol diet by improving lipid metabolism and bile acid excretion.

The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes

The paper investigates the structure of insulin granule cores and shows that their size reduction in type-2 diabetes correlates with impaired insulin secretion.

VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry

VE607 inhibits SARS-CoV-2 infection by stabilizing the RBD in the 'up' conformation and blocking S-ACE2 interaction across multiple variants.

Development and Validation of Fluorinated Amino Acid Parameters for use with the AMBER ff15ipq Protein Force Field

The paper develops and validates force field parameters for fluorinated amino acids in the AMBER ff15ipq force field, enabling accurate MD simulations of fluorinated proteins and validating them with experimental NMR data.

Stem embolism vulnerability curve depends on methods used: is there a fifth mechanism of cavitation?

This paper investigates how different methods for measuring stem embolism vulnerability affect results, finding that nano-particles may induce early cavitation and that the origin of these particles might be from living cells near vessels.

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

This study compares how SARS-CoV-2 and other betacoronaviruses activate the IRE1α/XBP1 ER stress pathway in human lung cells, finding that SARS-CoV-2 only partially activates it, potentially evading host immune detection.

Vaccine-breakthrough infection by the SARS-CoV-2 Omicron variant elicits broadly cross-reactive immune responses

This study examines immune responses in vaccine-breakthrough Omicron infections, finding rapid cross-reactive neutralizing antibodies and T cell responses against multiple variants.

Waning immune responses against SARS-CoV-2 among vaccinees in Hong Kong

This study compares immune responses between BioNTech and Sinovac vaccines in Hong Kong, finding Sinovac induces lower neutralizing antibodies and wanes faster against SARS-CoV-2 variants.

A quadratic analytical solution of root pressure generation provides insights about bamboo and other species

The paper derives an analytical solution for root pressure and applies it to a 7-meter bamboo shoot's hydraulic architecture.

Carbon nanotube biocompatibility in plants is determined by their surface chemistry

This study investigates the biocompatibility of single-walled carbon nanotubes in plants, finding that surface chemistry determines toxicity and cellular response.

Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform

This study develops a reliable alveolar type 2 organoid platform to model diverse genetic subtypes of lung adenocarcinoma in vitro and in vivo.

Vertical transmission of tissue microbiota in Caenorhabditis elegans

This study shows that C. elegans vertically transmits gut bacteria to offspring, which colonize tissues during development and influence immunity.

Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination

This study shows that intranasal influenza-based boost vaccination enhances mucosal and systemic immunity against SARS-CoV-2, effectively preventing infection in both upper and lower respiratory systems.

Lineage Recording Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution

The paper tracks tumor evolution in a mouse model using lineage tracing and single-cell RNA-seq, revealing plasticity, fitness-associated programs, and stereotypical evolutionary trajectories.