J. Yu

Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

Assessment of AI-based Protein Structure Prediction for the NLRP3 Target

This study evaluates AI-based protein structure prediction for NLRP3, showing that AI models can generate reliable structures useful for small-molecule drug discovery.

A trimeric NTD and RBD SARS-CoV-2 subunit vaccine induced protective immunity in CAG-hACE2 transgenic mice and rhesus macaques

ReCOV, a trimeric SARS-CoV-2 subunit vaccine, induced neutralizing antibodies and complete protection against SARS-CoV-2 in mice and rhesus macaques.

mRNA Vaccines Induce Rapid Antibody Responses in Mice

This study shows mRNA vaccines induce rapid antibody responses in mice by day 5, outperforming DNA, protein, and adenovirus vaccines for SARS-CoV-2 and HIV-1 antigens.

RAF conformational autoinhibition and 14-3-3 proteins promote paradoxical activation

The paper investigates paradoxical activation of RAF kinases, showing that 14-3-3 proteins enhance this effect by stabilizing RAF conformations and dimerization.

A method for identifying environmental stimuli and genes responsible for genotype-by-environment interactions from a large-scale multi-environment data set

This paper introduces a method to identify environmental stimuli and genes involved in genotype-by-environment interactions using large-scale multi-environment data.

A focal adhesion kinase-YAP signaling axis drives drug tolerant persister cells and residual disease in lung cancer

This study identifies a FAK-YAP signaling axis that drives drug-tolerant persister cells and residual disease in lung cancer, showing that inhibiting this axis improves tumor response to targeted therapies.

A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

This paper identifies a monoclonal antibody, 2-36, that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses, with a conserved epitope in the RBD identified through cryo-EM.

A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression

The paper identifies an antisense RNA, NQO1-AS, that promotes breast cancer metastasis by stabilizing NQO1 mRNA, enhancing oxidative stress tolerance and enabling lung colonization.

HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming

This study identifies HOXB13's AR-independent role in suppressing lipogenesis via HDAC3-mediated epigenetic repression, linking its loss to metastatic prostate cancer progression.

Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery Against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques

This study evaluates the protective efficacy of oral SARS-CoV-2 delivery in rhesus macaques against respiratory challenges, finding limited immunogenicity and partial protection.

An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

Drug targeting to sites of oxidative stress using the Baeyer-Villiger reaction

The paper develops a 1,2-dicarbonyl compound that selectively activates Nrf2 at sites of oxidative stress, reversing pain in mice and offering a targeted approach for treating oxidative stress-related disorders.

CRP immunodeposition and proteomic analysis in abdominal aortic aneurysm

This study investigates mCRP deposition in AAA and identifies associated proteomic changes and enriched pathways.

Clinically-relevant T cell expansion protocols activate distinct cellular metabolic programs and phenotypes

The paper compares five T cell expansion protocols and finds they induce distinct metabolic programs and phenotypes, with some conditions impairing T cell function despite metabolic adaptation.

Optimization of Non-Coding Regions Improves Protective Efficacy of an mRNA SARS-CoV-2 Vaccine in Nonhuman Primates

This study compares two mRNA SARS-CoV-2 vaccines in nonhuman primates, showing that CV2CoV, with optimized non-coding regions, provides better immune responses and protection than CVnCoV.

An ultrapotent neutralizing bispecific antibody with broad spectrum against SARS-CoV-2 variants

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

Metabolism is a major driver of hydrogen isotope fractionation recorded in tree-ring glucose of Pinus nigra

This study identifies metabolism as a key driver of hydrogen isotope fractionation in tree-ring glucose of Pinus nigra, showing it explains ~60% of deuterium variability.

Switching Promotor Recognition of Phage RNA Polymerase in Silico Following Path along Lab Directed Evolution

This study uses computational methods to investigate how phage RNA polymerase evolves to switch promoter recognition from T7 to T3 through structural and electrostatic changes.

A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates

This paper describes a protein subunit vaccine candidate produced in yeast that protects non-human primates against SARS-CoV-2, showing high neutralizing antibody titers and reduced viral loads after challenge.

WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

Probing remdesivir nucleotide analogue insertion to SARS-CoV-2 RNA dependent RNA polymerase in viral replication

This study computationally examines how remdesivir nucleotide analogue binds and inserts into SARS-CoV-2 RdRp, showing it has a lower energy barrier than ATP insertion.

Lentiviral vector optimization enhances the expression and cytotoxicity of chimeric antigen receptors

This study compares single-promoter and dual-promoter lentiviral vectors for CAR expression and cytotoxicity in engineered NK cells, finding that the single-promoter pCDHsp enhances expression and cytotoxicity.

Notch-Induced Endoplasmic Reticulum-Associated Degradation Governs Thymocyte β-Selection

This study identifies ERAD as a proteostasis checkpoint during β-selection, showing Sel1l deficiency causes ER stress and apoptosis, impairing β T cell development.

Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

This paper reports the cryo-EM structure of antibody 5-7, which binds to a distinct site in the SARS-CoV-2 spike NTD, showing neutralization resistance to variants of concern.

The Myogenesis Program Drives Clonal Selection and Drug Resistance in Rhabdomyosarcoma

This study shows that targeting developmental states in rhabdomyosarcoma can prevent disease recurrence by eliminating myoblast-like cells and inhibiting EGFR-dependent paraxial mesoderm populations.