Autophagy in Disease and Therapy

Biallelic Loss of Molecular Chaperone Molecule AIP Results in a Novel Severe Multisystem Disease Defined by Defective Proteostasis

This study shows that biallelic AIP loss causes a severe pediatric disease with proteostasis defects, observed in human and zebrafish models.

EGFR meets hATG8s - Biophysical and structural insights supporting a unique role of GABARAP during receptor trafficking

The paper identifies a GABARAP binding site on EGFR and shows its role in EGFR degradation through biophysical and structural analysis.

Suppression of autophagy induces senescence in the heart

This study shows that suppressing autophagy in the heart leads to cardiomyocyte senescence, which worsens cardiac function.

The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

This paper identifies the V1H subunit of V-ATPase as a regulator of ATG16L1 recruitment in response to pH gradient disruption, linking V-ATPase function to autophagy activation.

Autophagy-mediated CTR1 turnover orchestrates the reciprocal interaction between autophagy and ethylene signaling

This study shows that autophagy regulates CTR1 protein turnover, which in turn modulates ethylene signaling, revealing a reciprocal relationship between autophagy and ethylene in plant stress responses.

A retrograde transit filter mediated by optineurin controls mitostasis in distal axons

The paper identifies a retrograde transit filter in distal axons mediated by optineurin that regulates mitochondrial homeostasis, independent of PINK1 and parkin.

Ccr4-Not ubiquitin ligase signaling regulates ribosomal protein homeostasis and inhibits 40S ribosomal autophagy

This study shows that Ccr4-Not ubiquitin ligase activity maintains ribosomal protein homeostasis and inhibits 40S ribosomal autophagy through interactions with the endolysosomal pathway.

Context-dependent roles for autophagy in myeloid cells in tumor progression

This study shows that autophagy in myeloid cells can either promote or suppress tumor growth depending on the tumor context, highlighting the need for targeted autophagy inhibitors in cancer therapy.

Egg MVBs elicit an antimicrobial pathway to degrade paternal mitochondria after fertilization

The paper shows that egg-derived MVBs use the LAP pathway to eliminate paternal mitochondria in Drosophila, with potential parallels in mammals.

Porphyromonas gingivalis activates Heat-Shock-Protein 27 to drive a LC3C-specific pro-bacterial form of select autophagy that is redox sensitive for intracellular survival in human gingival mucosa

This paper identifies how Porphyromonas gingivalis uses HSp27 phosphorylation to drive a redox-sensitive, LC3C-specific autophagy mechanism that supports its intracellular survival in human gingival cells.

Unlocking a New Path: An Autophagometer that Measures Flux Using a Non-Fluorescent Immunohistochemistry Method

This paper introduces a non-fluorescent immunohistochemistry method to measure autophagy flux, demonstrating its cost-effectiveness and applicability to clinical settings.

ER-associated biogenesis of PINK1 preprotein for neuronal mitophagy

The paper shows that PINK1 precursor translation in neurons requires ER and endolysosome interaction, with DNAJB6 facilitating its transport to mitochondria for mitophagy.

The GTPase-activating protein CG42795 is a potent neuronal regulator of ageing in Drosophila melanogaster

This study identifies CG42795 as a neuronal GTPase-activating protein that enhances autophagy, locomotor ability, and lifespan in Drosophila, with conserved effects in human cells.

The zebrafish as a new model for studying chaperone-mediated autophagy unveils its role in spermatogenesis

This study establishes zebrafish as a model for studying chaperone-mediated autophagy (CMA), revealing its role in spermatogenesis and tissue-specific variations.

PAK6 promotes neuronal autophagy by regulating TFEB nuclear translocation.

This study identifies PAK6 as a positive regulator of neuronal autophagy through TFEB nuclear translocation, with implications for neurodegenerative disease treatment.

GSK-3alpha-BNIP3 axis promotes mitophagy in human cardiomyocytes under hypoxia

This study identifies a novel mechanism by which GSK-3 promotes mitophagy in human cardiomyocytes under hypoxia through BNIP3 upregulation and interaction.

KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy

This study shows that KAT8 inhibition via MG149 blocks PINK1-dependent mitophagy initiation but promotes mitochondrial delivery to lysosomes without toxins.

H2O2 mediated MAPK-mTOR crosstalk determines the XIAP and FLIP degradation pathways and development of resistance to Imatinib

This study shows H2O2-mediated mTOR activation determines protein degradation pathway and Imatinib resistance in K562 cells.

The fine-tuning of synapse development by oxidative stress and autophagy requires presynaptic ATM kinase

This study shows that presynaptic ATM kinase in Drosophila coordinates autophagy and oxidative stress responses to regulate synapse development and prevent neurodegeneration.

Modifying Azithromycin to Mitigate Arrested Autophagy

This paper shows azithromycin inhibits autophagy and presents a modified version, AZM-[O], that reduces this effect while retaining antimicrobial and immunomodulatory functions.

Epg5 links proteotoxic stress due to defective autophagic clearance and epileptogenesis in Drosophila and Vici Syndrome patients

This study links proteotoxic stress from defective autophagy to epileptogenesis in Drosophila and Vici Syndrome patients, suggesting autophagy-stimulating diets as a potential treatment.

The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection

This study shows Salmonella Typhimurium inhibits ER-phagy by targeting FAM134B, enhancing its survival and causing intestinal damage in mice.

Compartmentalisation proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation

The paper uses proteomics and other methods to study endolysosomal changes in a goat model of atrial fibrillation, identifying upregulated pathways and specific proteins.

SCD1 and monounsaturated lipids are required for autophagy and survival of adipocytes

This study shows that SCD1 and monounsaturated lipids are essential for autophagy and survival of adipocytes, with SCD1 deficiency causing autophagosome accumulation and cell death.

Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner

This study shows Rab11a-Atg9A interaction regulated by mTOR is necessary for autophagy initiation at dendritic spines in response to NMDA receptor stimulation.

miRNA family miR-29 inhibits PINK1-PRKN dependent mitophagy via ATG9A

The paper identifies miR-29 and ATG9A as regulators of mitophagy and discovers EOPD-linked variants in ATG9A.

Assessing Autophagy Flux in Glioblastoma Temozolomide Resistant Cells

This study develops a method to measure autophagy flux in TMZ-resistant glioblastoma cells using imaging and biochemical assays, providing insights into chemoresistance mechanisms.

The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate lysosomal stress responses

This study identifies the V-ATPase-ATG16L1 axis as a mechanism recruiting LRRK2 to stressed lysosomes, facilitating lysosomal stress responses independent of canonical autophagy.

Atg15 is a vacuolar phospholipase that disintegrates organelle membranes

This study shows that Atg15 is a vacuolar phospholipase that disintegrates organelle membranes by degrading phospholipids in acidic environments.

The Wolfram-like variant WFS1E864K destabilizes MAM and compromises autophagy and mitophagy in human and mice.

This study shows that the WFS1E864K variant reduces MAM integrity and disrupts autophagy and mitophagy in human and mouse models of Wolfram-like syndrome.