Parkinson's Disease Mechanisms and Treatments

Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function in Caenorhabditis elegans

The paper shows that morphological changes in dopaminergic neurons of C. elegans correlate with functional impairments, as worms with dendrite degeneration paralyze more in dopamine solutions.

eQTL mapping in transgenic alpha-synuclein carrying Caenorhabditis elegans recombinant inbred line

The paper maps eQTLs in a transgenic C. elegans RIL panel to identify genetic modifiers of alpha-synuclein aggregation and PD-related pathways.

Interaction of an alpha-synuclein epitope with HLA-DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson's disease

This study shows that immunizing HLA-DRB1*15:01 mice with the alpha-synuclein epitope -syn32-46 causes intestinal inflammation, neuron loss, and constipation, mimicking prodromal Parkinson's disease features.

Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and psychiatric disease

A mouse model with patient-derived DAT mutations reveals dopaminergic dysfunction linked to parkinsonism and psychiatric symptoms through behavioral and neurochemical changes.

Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression.

This study shows honokiol reduces alpha-synuclein mRNA and protein levels in models of Parkinson's disease by modulating SNCA gene expression, identifying potential therapeutic targets.

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging

The paper uses PET imaging to show increased dopamine D2 receptor binding in LRRK2-R1441C rats, suggesting receptor upregulation as a compensatory response to dopamine deficits.

Blood-based Nano-QuIC: Inhibitor-resistant Detection of Seeding Activity in Patients Diagnosed with Parkinson Disease

This paper introduces Nano-QuIC, a method that improves the detection of misfolded α-synuclein in blood samples from Parkinson's patients compared to traditional RT-QuIC.

Association of genetic variation at the GJA5/ACP6 locus with motor progression in Parkinson's

This study identifies genetic variants associated with motor progression in Parkinson's disease using GWAS and functional analysis.

Synapsin E-domain is essential for α-synuclein function

The paper identifies the synapsin E-domain as essential for α-synuclein function, showing it binds to α-synuclein and is necessary for its synaptic effects.

Time perception reflects individual differences in motor and non-motor symptoms of Parkinson's disease

The paper quantifies how time perception varies with motor and non-motor symptoms in Parkinson's disease, linking these differences to dopaminergic mechanisms.

VPS35 and α-Synuclein Fail to Interact to Modulate Neurodegeneration in Rodent Models of Parkinson's Disease

This study investigates the interaction between VPS35 and α-synuclein in PD models and finds no significant functional or pathological interaction.

FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provides a target for Pink1 phosphorylation in vivo

The paper shows FBXO7/ntc and USP30 regulate basal mitophagy through opposing ubiquitination and deubiquitination mechanisms, with implications for Parkinson's disease therapy.

Exome sequencing in Asian populations identifies rare deficient SMPD1 alleles that increase risk of Parkinson's disease

The paper identifies rare SMPD1 variants in Asian populations that increase Parkinson's disease risk through exome sequencing and functional assays.

Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease

This study shows that midbrain dopamine loss in a mouse model of Parkinson's disease reduces thalamocortical input to the motor cortex while increasing its output.

Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished GDNF-signaling

This study examines changes in GDNF receptor expression in the striatum and substantia nigra following a nigrostriatal lesion in rats, finding differential expression patterns of GFR-1 and RET that may impact GDNF therapeutic efficacy.

The chromatin modulating NSL complex regulates genes and pathways genetically linked to Parkinsons disease

The paper investigates the regulatory role of the NSL complex in Parkinson's disease by analyzing gene expression and regulatory networks in brain tissues.

A dual target molecular MRI probe for noninvasive profiling of pathologic alpha-synuclein and microgliosis in a mouse model of Parkinson's disease

Comparison of Anatomical and Diffusion MRI for detecting Parkinson's Disease using Deep Convolutional Neural Network

This study compares anatomical and diffusion MRI for Parkinson's disease detection using deep convolutional neural networks, finding that dMRI-based models show promise for classification.

Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson's disease

The paper investigates the neuroprotective effects of polyphenol-rich extracts against paraquat and rotenone-induced neurotoxicity in Parkinson's disease models, identifying mechanisms involving antioxidant pathways and mitochondrial function.

Altered TFEB subcellular localization in nigral dopaminergic neurons of subjects with prodromal, sporadic and GBA-related Parkinson's disease and Dementia with Lewy bodies

The paper examines TFEB subcellular localization in Parkinson's and Lewy body disease brains, finding altered distribution linked to disease stages and GBA variants.

Totally tubular: ASO-mediated knock-down of G2019S-Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages

This study shows that reducing mutant Lrrk2 in macrophages decreases lysosomal tubule formation and pro-inflammatory responses, suggesting potential therapeutic benefits for LRRK2-related Parkinson's but possible immune system side effects.

MAPT allele and haplotype frequencies in Nigerian Africans: population distribution and association with Parkinsons disease risk and age at onset.

The paper examines MAPT haplotype frequencies in Nigerian Africans and finds no association between the H1 haplotype and Parkinson's disease risk or age at onset.

Parallel Neurodegenerative Phenotypes in Sporadic Parkinsons Disease Fibroblasts and Midbrain Dopamine Neurons

The paper identifies parallel neurodegenerative phenotypes in fibroblasts and iPSC-derived dopamine neurons from sporadic Parkinson's disease patients, revealing shared and distinct molecular and cellular alterations.

Cortex-wide topography of 1/f-exponent in Parkinson's disease

This study analyzes resting-state MEG data to show that Parkinson's disease is associated with widespread changes in cortical aperiodic activity, specifically increased λ values across most brain regions.

Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice.

This study shows that phasic dopamine release in mice is not essential for basic motor behaviors, as motor functions remain intact despite near-complete loss of activity-dependent dopamine release.

Preserved striatal innervation and motor function despite severe loss of nigral dopamine neurons following mitochondrial dysfunction induced by mtDNA mutations

This study shows that mice with severe loss of nigral dopamine neurons due to mtDNA mutations still maintain motor function through preserved striatal innervation.

Overexpression of human alpha-synuclein leads to dysregulated microbiome and metabolites with ageing in a rat model of Parkinson disease

This study shows that overexpression of human alpha-synuclein in rats leads to gut microbiome dysbiosis, altered metabolites, and aging-related changes that can be modulated by antibiotics.

Theta oscillations and minor hallucinations in Parkinson's disease reveal decrease in frontal lobe functions and later cognitive decline

The paper investigates if minor hallucinations in Parkinson's disease are linked to frontal theta oscillations and cognitive decline, finding a correlation between these factors and later cognitive impairment.

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo

The paper visualizes alpha-synuclein inclusions and iron deposition in M83 mouse models of Parkinson's disease using in vivo imaging and ex vivo validation techniques.

Behavioral effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice

This study examines the behavioral effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice, finding both beneficial and adverse effects with chronic treatment.