Telomeres, Telomerase, and Senescence

Natural diversity of telomere length distributions across 100 Saccharomyces cerevisiae strains

The paper analyzes telomere length distributions in 100 Saccharomyces cerevisiae strains, revealing diversity influenced by ploidy, subtelomere structure, and Y element content.

Identification of lipid senolytics targeting senescent cells through ferroptosis induction

This study identifies lipid senolytics that kill senescent cells via ferroptosis, extending healthspan in mice by targeting ACSL4, LPCAT3, and ALOX15.

La protein binding to telomerase RNA supports an evolutionary relationship between plant and ciliate telomerase pathways

The paper shows that AtLa1 binds to telomerase RNA in Arabidopsis, similar to LARP7 in ciliates, suggesting conserved RNA biogenesis pathways between plants and ciliates.

Transplanting ANXA1- CD8+ Naive T cells Delay Aging Through Senolysis

This study shows that transplanting ANXA1-negative CD8 naive T cells extends lifespan and improves health in aged mice by reducing senescence.

Induction of Senescence During Postpartum Mammary Gland Involution supports tissue remodeling and promotes postpartum tumorigenesis

This study shows that senescence during postpartum mammary gland involution supports tissue remodeling but also promotes tumorigenesis by enhancing tumor-initiating cell plasticity.

Transient telomere uncapping triggers telomeric and subtelomeric rearrangements

This study shows that transient telomere uncapping in yeast causes genomic rearrangements and telomere elongation, with implications for genome stability and evolution.

SMARCAL1 is a candidate therapeutic target for ALT-positive tumors

The paper identifies SMARCAL1 as a key regulator of ALT metabolism and a potential therapeutic target for ALT-positive tumors.

BAP1 Loss Induces Senescence and Enhances the Response to Radiation Therapy and Senolytics

This study shows BAP1 loss drives senescence in uveal melanoma and makes tumors more responsive to senolytics and radiation.

TARPON - a Telomere Analysis and Research Pipeline Optimized for Nanopore

TARPON is a Nextflow pipeline for analyzing telomeres sequenced on Nanopore, providing a user-friendly interface and customizable analysis for various applications.

Proteogenomic Profiling Reveals a Distinct Endogenous p16INK4a-Associated Senescence Signature in the Human Ovary.

The paper identifies a distinct p16INK4a-associated senescence signature in human ovarian tissue through proteogenomic profiling and spatial analysis.

Identification and characterization of a TRF2-like telomere-binding protein in Arabidopsis

The paper identifies TRFL7 as a telomere-binding protein in Arabidopsis, showing it functions similarly to human TRF2 in telomere maintenance.

Reproducible in vivo applications of the p16-3MR model in senescence research

This paper validates the reproducibility and utility of the p16-3MR mouse model for studying senescent cells across various conditions and discusses its strengths and limitations.

Integrative transcriptomic identification of cellular senescence beyond marker limitations

The paper develops a machine learning classifier to identify cellular senescence using single-cell RNA-seq data, finding it outperforms marker-based approaches and reveals new mechanistic insights.

Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs oligodendrocyte functions and alters neuronal activity

This study identifies soluble DLK1 from senescent microglia as a factor impairing oligodendrocyte function and altering neuronal activity in aging.

SENOMORPHIC EFFECT OF GENETIC AND CHEMICAL PARTIAL REPROGRAMMING

This study shows genetic and chemical partial reprogramming targets senescent cells to reduce aging-related inflammation and improve mitochondrial function in aged mice without restoring proliferation.

Targeting the senescence-associated immune checkpoint GD3 ganglioside extends healthspan and blunt age-related diseases with sex-specific benefits.

This study shows that targeting GD3 ganglioside, a senescence-associated immune checkpoint, improves healthspan and reduces age-related diseases with sex-specific benefits in mice.

Functional inactivation of the telomerase chaperone TCAB1 primes cells for the activation of ALT in osteosarcoma

The paper identifies structural variations in TP53 that inactivate TCAB1, a telomerase chaperone, and show these variations are prevalent in ALT-positive osteosarcoma tumors.

Parental age effects on offspring telomere length across vertebrates: a meta-analysis

This study meta-analyzes parental age effects on offspring telomere length across vertebrates, finding a positive human effect but no significant effect in non-human vertebrates.

The senescence-inhibitory p53 isoform Δ133p53α represses the proinflammatory chemokine CXCL10 in progeria model mice and naturally aged mice

This study shows that Δ133p53 reduces CXCL10 levels in progeria and aged mice, linking it to anti-inflammatory effects.

Telomere length can be estimated from fish scales

This study adapts a qPCR method to estimate relative telomere length from archived fish scales, finding variation in telomere length across rivers, age classes, and body size in brown trout.

Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

SenSeqNet: A Deep Learning Framework for Cellular Senescence Detection from Protein Sequences

SenSeqNet detects cellular senescence from protein sequences with 83.55% accuracy using a hybrid LSTM-CNN architecture and ESM-2 embeddings.

Single-cell RNA sequencing reveals distinct senotypes and a quiescence-senescence continuum at the transcriptome level following chemotherapy

The paper uses single-cell RNA sequencing and time-lapse imaging to distinguish quiescence and senescence after chemotherapy, revealing a continuum of cell-cycle withdrawal.

Cancer-associated DAXX mutations reveal a critical role for ATRX localization in ALT suppression

The paper investigates how DAXX mutations affect ALT suppression by analyzing their impact on ATRX localization.

Senescent CD8+ T Effector Memory Cells are Functionally Impaired, Enriched in Aging and Disease, and a Barrier to Immunotherapy

This study identifies senescent CD8+ T effector memory cells as functionally impaired and enriched in aging and disease, and shows they hinder immunotherapy responses.

Senescent cells secrete chromatin components via senescence-associated extracellular particles

This study shows senescent cells release chromatin components via extracellular particles, activating inflammation in neighboring cells and being present in aged mice.

Nanopore whole-genome sequencing reveals conserved chromosome-specific telomere architecture across tissues and populations

This study uses Nanopore whole-genome sequencing to show conserved chromosome-specific telomere length patterns across tissues and populations, revealing coordinated regulation and potential disease risk factors.

p16INK4A expression induces paracrine senescence via small extracellular vesicles

This study shows that p16INK4A-expressing fibroblasts release small extracellular vesicles that induce paracrine senescence in neighboring cells.

SLFN11 puts the brakes on Alternative lengthening of telomeres

This study identifies SLFN11 as a suppressor of the ALT telomere maintenance pathway, showing its re-expression reduces ALT activity in cancer cells.

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways

This study shows that overexpressing an Alu transposon in human fibroblasts causes widespread disruptions in aging-related pathways across transcriptome, proteome, and secretome.