interferon and immune responses

PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation

This study identifies PRRSV's Nsp5 protein as a mechanism to inhibit the cGAS-STING-IFN antiviral pathway by blocking STING translocation and activation, thereby promoting viral replication.

Attenuation of IFITM proteins antiviral activity through sequestration into intraluminal vesicles of late endosomes

This study shows that CsA treatment sequesters IFITM proteins into intraluminal vesicles of late endosomes, reducing their antiviral activity by preventing viral fusion with the limiting membrane of these compartments.

5' cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5

This study shows that MDA5 senses HIV-1 unspliced RNA based on 5' cap structure and nuclear export pathway, revealing how the virus evades innate immunity.

Alternate isoforms of IRF7 Differentially Regulate Interferon Expression to Tune Response to Viral Infection

This study identifies an alternative splicing mechanism in IRF7 that generates a protein isoform with enhanced transcriptional activity, leading to increased resistance to viral infection.

MERS-CoV antagonizes PKR activation by inhibiting its condensation at viral replication complexes

This study shows MERS-CoV inhibits PKR activation by blocking its condensation on viral dsRNA, revealing a mechanism by which the virus evades innate immune responses.

Dose-dependent interferon programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination

This study compares immune responses to different COVID-19 vaccines in humans, finding distinct interferon programs in myeloid cells based on vaccine type and dose timing.

DUX4-stimulated genes define an antiviral defense program in human placental trophoblasts

The paper identifies DUX4-stimulated genes as an antiviral defense program in human trophoblasts, specifically targeting herpesviruses through an alternative pathway to the IFN response.

Broad-spectrum RNA antiviral inspired by ISG15-/- deficiency

The paper identifies a set of 10 ISGs that confer broad-spectrum antiviral resistance and demonstrates their efficacy in protecting against multiple viruses in vivo.

Tissue-Resident Macrophage and Dendritic Cell Cooperation Drives Type I IFN Immunity to Enteroviruses in the Liver

This study identifies Kupffer cells and dendritic cells as key sources of type I IFN during echovirus infection, showing their role in liver immunity and pathogenesis.

Viral soluble decoy receptor as a novel treatment for IFN-I triggered diseases

This study explores the use of viral IFN-I binding protein as a therapeutic to neutralize IFN-I and treat autoinflammatory diseases in mouse models.

RIG-I-dependent tumor-intrinsic type I interferon signaling restricts growth in breast cancer 3D culture

This study identifies type I interferon signaling as a tumor-intrinsic suppressor of proliferation in 3D breast cancer spheroids through RIG-I-mediated sensing of cytosolic RNA.

A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs

This study identifies a two-step mechanism by which influenza virus mini viral RNAs (mvRNAs) activate RIG-I through non-canonical transcription and RNA structure-dependent binding.

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

This study identifies age-related rewiring of type I IFN signaling in immune cells linked to increased inflammation and altered antibody responses in COVID-19.

Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localization

The paper identifies how cGAS is recruited to organelle membranes via phase separation, revealing a mechanism to regulate its activity and innate immune responses.

Characterizing the transcriptomic response to interferon and infection in European Domestic Ferret respiratory tissues using long-read RNA sequencing

This study uses long-read RNA sequencing to analyze the transcriptomic response to interferon and influenza infection in ferrets, identifying ISGs and novel transcripts.

Functional Roles for RNA Ribosylation in Mammalian Cells

This study shows RNA ribosylation inhibits translation, decreases RNA stability, and activates antiviral immune responses in mammalian cells during chikungunya virus infection.

RNase L regulates the antiviral proteome by accelerating mRNA1decay, inhibiting nuclear mRNA export, and repressing RNAPII-2mediated transcription

This study shows RNase L reduces antiviral proteins by inhibiting mRNA export and RNAPII-mediated transcription during flavivirus infection.

Spatial dynamics of IFITM1: a core component of the interferon-stimulated gene-resistance signature in glioma

This study investigates the spatial dynamics of IFITM1 in glioma, showing context-dependent localization and interactions with IFITM3, suggesting potential therapeutic targets.

Fatty Acid Synthase associates with nuclear-derived cytoplasmic dsRNA molecules and influences antiviral innate immune response

This study shows FASN depletion increases cytoplasmic endogenous dsRNA and enhances antiviral innate immune responses.

Telomere replication stress-induced DNA damage response triggers inflammatory signaling via canonical and non-canonical STING pathways

The paper shows that TRF1 loss in MEFs triggers inflammation via ATR/cGAS/STING and ATM/STING pathways by inducing DNA damage and cytosolic DNA.

A non-canonical cGAS-STING pathway drives cellular and organismal aging

This study identifies a non-canonical cGAS-STING pathway that drives aging and progeria by promoting inflammation and senescence, and shows that targeting this pathway can improve aging-related phenotypes.

STING agonists drive recruitment and intrinsic type I interferon responses in monocytic lineage cells for optimal anti-tumor immunity

This study shows STING agonists enhance anti-tumor immunity by recruiting monocytic cells and inducing IFN-I responses, with IL-18 playing a key role in CD8 T cell activation.

Borrelia burgdorferi Secretes c-di-AMP as an Extracellular Pathogen-Associated Molecular Pattern to Elicit Type I Interferon Responses in Mammalian Hosts

This study identifies c-di-AMP as a key extracellular PAMP secreted by Borrelia burgdorferi that triggers type I interferon responses in mammalian hosts via STING signaling.

Avian interferon regulatory factor (IRF) family reunion: IRF3 and IRF9 found

This study identifies and characterizes IRF3 and IRF9 genes in avian species, confirming their roles in IFN signaling and revealing evolutionary patterns.

Orthosteric STING inhibition elucidates molecular correction of SAVI STING

This study identifies a critical residue for STING activation and shows how an orthosteric inhibitor can partially correct a SAVI mutation.

Human type-I interferon omega holds potent antiviral properties and promotes cytolytic CD8+ T cell responses

This study shows human IFN-omega has strong antiviral effects and enhances CD8+ T cell responses against SARS-CoV-2.

Crosstalk Between ALPK1 and STING: A Synergistic Axis in Innate Immune Activation and Human Inflammatory Disease

This study identifies a bidirectional crosstalk between ALPK1 and STING that amplifies innate immune responses and contributes to inflammatory disease.

The IFN I response in tumor cells is shaped by PARP7-p300/CBP interactions through distinct loss- and gain-of-function mechanisms

This paper identifies p300 and CBP as PARP7 substrates that regulate IFNβ through loss- and gain-of-function mechanisms in colorectal cancer cells.

The aryl hydrocarbon receptor interacting protein suppresses RNA virus-induced type I IFN and IL-6 in mouse macrophages

This study shows that AIP suppresses type I IFN and IL-6 production in mouse macrophages during RNA virus infection by regulating IRF7 degradation.

Stress from environmental change drives clearance of a persistent enteric virus

The paper shows that stress from environmental change can clear a persistent enteric virus by inducing immune responses and reducing viral persistence.