interferon and immune responses

The assembly of stress granule-like foci during foot-and-mouth disease virus infection is uncoupled from activation of cellular intrinsic antiviral signalling

This study shows that stress granule formation during FMDV infection is independent of innate immune activation, and that preventing their disassembly reduces viral replication.

Annexin A2 mediates RIG-I-like receptor responses to viral infection

This study identifies Annexin A2 as a critical mediator of RIG-I-like receptor responses to viral infection by promoting MDA5 oligomerization and enhancing interferon production.

Mammalian ZAP and KHNYN can independently restrict CpG-enriched avian viruses

The paper shows mammalian ZAP and KHNYN can restrict CpG-enriched avian viruses, with human ZAP or KHNYN independently limiting CpG-enriched IAV in chicken and human cells.

A p97-PML NBs axis is essential for chromatin-bound cGAS untethering and degradation upon senescence-prone DNA damage

This study shows that p97 and PML nuclear bodies regulate cGAS degradation after DNA damage, affecting the DNA damage response and senescence.

STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma

This study shows that activating the STING pathway in osteosarcoma leads to tumor regression and immune memory, suggesting it as a therapeutic target.

IFIT1 is rapidly evolving and exhibits disparate antiviral activities across 11 mammalian orders

The paper shows IFIT1 genes evolve rapidly across mammals and exhibit varying antiviral activities against viruses like VEEV.

Small-molecule perturbation profiling reveals a mechanistic link between STING signaling and lipid metabolism in macrophages and dendritic cells

The paper identifies lipid metabolic pathway inhibitors that modulate STING signaling and IFN induction in mouse and human cells.

Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity

This study shows that transient skin inflammation activates hematopoietic stem/progenitor cells via type I interferon, altering systemic immunity and affecting atherosclerosis and influenza outcomes.

Effect of heme oxygenase-1 on the expression of interferon-stimulated genes

This study investigates how heme oxygenase-1 (HO1) affects interferon-stimulated gene (ISG) expression in response to various stressors, finding that TNF is a key inducer and HO1 influences nuclear retention of inflammatory transcription factors.

Type I Interferon production in myeloid cells is regulated by factors independent of Ptpn22

This study challenges previous findings by showing that PEP and its variant do not promote IFN-I production in myeloid cells, suggesting factors independent of PEP regulate this process.

RIG-I-like receptor-dependent type I Interferon regulates antigen dose and activation in yellow fever vaccine 17D-infected antigen presenting cells

This study shows that type I interferon, induced by RIG-I-like receptors, restricts YF17D replication in antigen-presenting cells, thereby limiting antigen presentation to T cells.

Specialization of ubiquitin ligases to distinct nucleic acid sensors

The paper identifies how SPRY domains in ubiquitin ligases recognize nucleic acid sensors, using AlphaFold to discover novel interactions and their implications for RNA vaccine design.

Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

This study shows that plasmacytoid dendritic cells (pDCs) and their interferons are dispensable or harmful in systemic and respiratory viral infections in mice.

Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity

The paper identifies 7-deazapurine protein conjugation as essential for type IV CBASS immunity, revealing the roles of Cap9 and Cap10 in this process.

Cgas deficiency promotes tumor growth by supporting B cell persistence and angiogenesis

This study shows that cGAS deficiency in mice promotes tumor growth by supporting B cell persistence and angiogenesis, leading to a pro-tumor immune environment.

IRF2 degradation tunes the innate immune response

The paper shows IRF2 degradation by IRF1 during immune responses enhances ISG transcription, revealing a regulatory circuit between IRF1 and IRF2 in innate immunity.

Observation of Higher-Order Assemblies Controlled by Protein One-dimensional Movement

The paper investigates how MDA5 CARDs assemble and interact with LGP2 through one-dimensional movement along dsRNA to regulate immune response.

Extensive adaptive changes in bat interferon pathway reveal specific molecular functions at the forefront of host - virus coevolution

This study identifies adaptive changes in bat interferon pathway genes, revealing positive selection on antiviral sensors and chemokine signaling components involved in host-virus coevolution.

Tumor cells upregulate CCL22 in a STING-dependent manner in response to paracrine factors released by STING-activated myeloid cells and type I interferons

The paper shows that STING activation in myeloid cells leads to paracrine factors that upregulate CCL22 in cancer cells, and that type I interferons also induce CCL22 via a STING-dependent mechanism.

Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistance

This study shows that PTEN loss in cancer cells activates intrinsic interferon signaling, leading to immune resistance and vulnerability to CDK12 inhibition.

The BTK-DDX41 axis of the STING pathway is activated during cytomegalovirus lytic infection

This paper identifies the activation of the BTK-DDX41-STING signaling pathway during CMV lytic infection and shows how the virus subverts this pathway by reducing DDX41 activity.

PARP14 is an interferon (IFN)-induced host factor that promotes IFN production and affects the replication of multiple viruses

This paper shows PARP14 promotes IFN production and has both antiviral and proviral functions against multiple viruses.

Healthy adipocytes provide a protective environment by limiting viral infection through cell-cell communication

The paper shows healthy adipocytes protect neighboring cells from viral infection through STING-dependent interferon-alpha secretion, and metabolic dysfunction reduces this antiviral activity.

The mammalian SKI complex is a broad-spectrum antiviral drug target that upregulates cellular cholesterol to inhibit viral replication

This paper identifies the SKI complex as a broad-spectrum antiviral target, showing that UMB18 increases cellular cholesterol via the mevalonate pathway to inhibit viral replication.

A genetic screen to identify deubiquitinases as regulators of IRF7

The paper identifies USP2 and OTUD5 as deubiquitinases regulating IRF7 activity through distinct ubiquitination mechanisms, impacting antiviral immunity.

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation

This study shows that SARS-CoV-2 deISGylation by PLpro suppresses innate immunity and promotes viral replication by modulating cellular metabolism.

A choanoflagellate cGLR-STING pathway reveals evolutionary links between bacterial and animal immunity

The paper identifies a cGLR-STING signaling pathway in choanoflagellates, showing evolutionary links between bacterial and animal immunity.

NAT10 Suppresses RNA Sensing Induced IFN-β Transactivation to Promote Viral Infection via Interfering with IRF3 Activities

This study shows NAT10 suppresses IFN-β transactivation by inhibiting IRF3, thereby promoting viral infection.

CRISPR with Transcriptional Readout reveals influenza transcriptionis modulated by NELF and can precipitate an interferon response

The paper introduces CRITR-seq, a CRISPR-based method to measure transcriptional effects, and identifies NELF as a regulator of influenza transcription and interferon response.

Plasmacytoid dendritic cells in the intestine preferentially produce interferon lambda at homeostasis contributing to tonic localized innate immune responses

This study identifies intestinal plasmacytoid dendritic cells (pDC) as a major source of homeostatic IFN-λ and shows TGF-β regulates their IFN production.