Barrier Structure and Function Studies

Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice

This study investigates how HA1 and ApoC3 siRNA affect lipoprotein-amyloid metabolism, neurovascular integrity, and cognitive function in diabetic mice, finding HA1 more effective than probucol or ApoC3 siRNA in reducing amyloid levels and preserving BBB integrity.

Inhibition of β-catenin signaling by Amyloid-β in endothelial cells impairs vascular barrier integrity

This study shows that Amyloid-β inhibits β-catenin signaling in endothelial cells, reducing BBB integrity and contributing to Alzheimer's Disease progression.

A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes

This study shows IL-10 signalling contributes to capillary stalling and cognitive impairment in type 1 diabetes by increasing vascular obstructions and reducing blood flow.

Screening activity of brain cancer-derived factors on primary human brain pericytes

The paper investigates how brain cancer-derived factors affect primary human brain pericytes, identifying specific signaling pathways and functional changes.

Aging disrupts blood-brain and blood-spinal cord barrier homeostasis, but does not increase paracellular permeability

The paper investigates aging effects on blood-CNS barriers in mice, finding no increase in paracellular permeability but changes in gene expression related to immune invasion and pericytes.

Reduced Folate Carrier 1 (RFC1/Slc19a1) Suppression Exacerbates Blood-Brain Barrier Breakdown in Experimental Ischemic Stroke in Adult Mice

This study shows that reducing RFC1 worsens BBB breakdown and increases infarct size in a mouse model of ischemic stroke.

L-Arginine and asymmetric dimethylarginine (ADMA) transport across the mouse blood-brain and blood-CSF barriers: evidence of saturable transport at both interfaces and CNS to blood efflux.

This study investigates the transport of L-arginine and ADMA across the blood-brain and blood-CSF barriers in mice, finding saturable transport and CNS-to-blood efflux of ADMA.

Drug Metabolism and Transport Capacity of Endothelial Cells, Pericytes, and Astrocytes: Implications for CNS Drug Disposition

The paper evaluates drug metabolism and transport in BBB cell types, finding distinct capacities in endothelial cells, pericytes, and astrocytes that affect CNS drug disposition.

Pericyte ablation causes hypoactivity and reactive gliosis in adult mice

This study shows that pericyte ablation in adult mice leads to blood-brain barrier leakage, gliosis, and behavioral changes such as reduced movement and impaired balance.

A Human Brain-Chip for modelling brain pathologies and screening of BBB crossing therapeutic strategies

The paper develops a human Brain-Chip model to study brain pathologies and test BBB-crossing therapies, showing in vitro/in vivo correlation for drug screening.

A Novel Mouse Model Demonstrates In Vivo Replenishment of Central Nervous System Pericytes After Successful Acute Ablation

This study develops a mouse model to ablate CNS pericytes and shows their regenerative capacity after acute injury.

Ultrastructural Organization of the Honeybee Blood-Brain Barrier and Comparison with Age

The paper describes the first global anatomical analysis of the honeybee worker blood-brain barrier and compares ultrastructural features between two age groups.

Rapamycin Treatment Reduces Brain Pericyte Constriction in Ischemic Stroke

This study shows rapamycin reduces brain pericyte contraction during ischemia but not viability, improving capillary diameter and openness after stroke.

Endolysosomal dysfunction in radial glia progenitor cells leads to defective cerebral angiogenesis and compromised Blood-Brain Barrier integrity

This study identifies endolysosomal dysfunction in radial glia progenitor cells as a cause of defective cerebral angiogenesis and BBB compromise in zebrafish, linking Notch3 processing defects to CSVD phenotypes.

Human iPSC-derived brain pericytes exhibit differences in inflammatory activation compared to primary human brain pericytes

This study compares the inflammatory responses of iPSC-derived brain pericytes to primary human brain pericytes, finding differences in NFκB and STAT1 activation and cytokine secretion.

Capillary regression leads to sustained local hypoperfusion by inducing constriction of upstream transitional vessels

The paper shows that capillary injury and regression lead to sustained vasoconstriction in upstream vessels, reducing blood flow in both injured and uninjured regions of the microvascular network.

Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction.

This study develops and validates a mouse model of sepsis-induced cognitive dysfunction, identifying molecular and functional changes in the cerebral microvasculature and their association with cognitive impairment.

Exploring Kp,uu,BBB Values Smaller than Unity in Remoxipride: A Physiologically-Based CNS Model Approach Highlighting Brain Metabolism in Drugs with Passive Blood-Brain Barrier Transport

This study investigates the brain distribution of remoxipride, showing that brain metabolism, not just BBB efflux, affects Kp,uu,BBB values less than 1.

Hematopoietic growth factors Regulate Entry of Monocytes into the Adult Brain via Chemokine Receptor CCR5

This study shows that SCF and G-CSF enhance monocyte adhesion to brain endothelial cells via CCR5, facilitating their entry into the adult brain to replenish perivascular macrophages.

LOSS OF CLDN5 -AND INCREASE IN IRF7- IN THE HIPPOCAMPUS AND CEREBRAL CORTEX OF DIABETIC MICE AT THE EARLY SYMPTOMATIC STAGE.

The paper identifies gene expression changes in the hippocampus and cerebral cortex of diabetic mice with minor cognitive deficits, highlighting CLDN5 downregulation and IRF7 upregulation as potential contributors to early cognitive decline.

Microglia are not required for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism

The paper investigates the role of microglia in maintaining blood-brain barrier properties in health and finds that microglia are not required, but PLX5622 treatment affects endothelial cholesterol metabolism.

Aging drives cerebrovascular network remodeling and functional changes in the mouse brain

This study identifies age-related changes in cerebrovascular structure and function in the mouse brain, including reduced vascular length and increased tortuosity in specific regions.

Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution compared to standard antibodies

This study compares the biodistribution of Fc-engineered molecules targeting BBB receptors with standard antibodies, showing distinct CNS and peripheral organ targeting.

Chronic β3 adrenergic agonist treatment improves brain microvascular endothelial function and cognition in aged mice

The neurovascular coupling response of the aged brain is brain-state dependent.

This study shows that neurovascular coupling in aged mice is slower and prolonged, with reduced Ca2+ signaling in vascular mural cells, and correlates with decreased spontaneous locomotion.

Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses at arteriole-capillary junctions.

The paper uses 3D imaging in awake mice to show astrocytes control neurovascular coupling by regulating blood flow through pre-capillary sphincters.

Associations between regional blood-brain barrier disruption, aging, and Alzheimers disease biomarkers in cognitively normal older adults

Rescue of Impaired Blood-Brain Barrier in Tuberous Sclerosis Complex Patient Derived Neurovascular Unit

This study uses patient-derived neurovascular units to show that TSC2 mutations impair BBB function, which can be rescued by wild-type astrocytes or rapamycin treatment.

Stress-induced dysfunction of neurovascular astrocytes contributes to sex-specific behavioral deficits

This study shows chronic stress causes sex-specific changes in astrocyte function and neurovascular integrity, leading to behavioral deficits in male mice.

Pericytes mediate neurovascular remodeling in chronic arterial hypertension

This study investigates how pericytes respond to chronic arterial hypertension in SHRSP rats, revealing phenotypic and metabolic changes that contribute to vascular remodeling and cerebral disease.