Barrier Structure and Function Studies

ARHGAP12 suppresses F-actin assembly to control epithelial tight junction mechanics and paracellular leak pathway permeability

This study identifies ARHGAP12 as a regulator of the paracellular leak pathway by suppressing F-actin assembly at tight junctions without affecting ion flux.

Spatial Transcriptomics of Schizophrenia Insular Cortex Reveals Blood-Brain Barrier Hyperglycolysis and Increased Parenchymal Mitochondrial Respiration

The paper uses spatial transcriptomics to analyze the insular cortex of schizophrenia patients and controls, identifying metabolic changes in the blood-brain barrier and parenchyma.

Canonical Wnt Signaling Suppresses Brain Endothelial Cell Transcytosis to Maintain Blood-Brain Barrier Integrity

This study shows that canonical Wnt signaling suppresses transcytosis in brain endothelial cells, maintaining blood-brain barrier integrity by regulating tight junctions and vesicle dynamics.

SSAO-mediated decrease of endothelial BDNF release affects neuronal GluA1 and PSD95 expression: a peripheral mechanism inducing NVU and CNS disturbances

The paper investigates how SSAO/VAP-1 affects BBB dysfunction and vascular BDNF release, leading to reduced synaptic markers in neurons in an Alzheimer's context.

Characterization of transcriptomic changes in the neurovascular unit of Alzheimiers transgenic mouse models using digital spatial profiling

The paper uses digital spatial profiling to analyze transcriptomic changes in the neurovascular unit of Alzheimer's transgenic mice, identifying dysregulated signaling and potential therapeutic targets.

Tie2-Dependent Mechanisms Promote Leptomeningeal Collateral Remodeling and Reperfusion Following Stroke

This study shows that Tie2 activation with Vasculotide enhances leptomeningeal collateral remodeling and reperfusion after stroke, while EphA4 inhibition mimics these effects, highlighting their opposing roles in vascular adaptation.

Modulation of blood-tumor barrier transcriptional programs improves intra-tumoral drug delivery and potentiates chemotherapy in GBM

This study identifies a 12-gene BTB signature, shows CDH5 as a core component, and demonstrates that BIA disrupts the BTB to enhance chemotherapy delivery and efficacy in GBM.

Exploring Hippocampal Vulnerability: Diminished Angiogenic Capacity in the Hippocampus Compared to the Cortex

The paper identifies reduced angiogenic capacity in the hippocampus compared to the cortex by analyzing gene expression in BBB-associated cells and validating findings in animal models.

Transferrin receptor-binding blood-brain barrier shuttle enhances brain delivery and efficacy of a therapeutic anti-Abeta antibody

This study shows that fusing an anti-Aβ antibody to a TfR1-binding Fab fragment enhances brain delivery and plaque clearance while reducing adverse effects in APP/PS1 mice.

IQGAP2 regulates blood-brain barrier immune dynamics

This study shows that IQGAP2 regulates immune cell entry into the CNS by modulating BBB function through adhesion receptors and antigen-processing machinery.

Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein

This paper demonstrates that binding antibodies to myelin oligodendrocyte glycoprotein (MOG) significantly increases their brain half-life when combined with transferrin receptor (TfR) mediated transport.

Anillin tunes contractility and regulates barrier function during Rho flare-mediated tight junction remodeling

This study shows Anillin regulates RhoA activity and actomyosin contraction during Rho flare-mediated tight junction repair, preventing barrier leaks.

Temporal Microenvironment Mapping (microMap) of Intracellular Trafficking Pathways of Cell-Penetrating Peptides Across the Blood-Brain Barrier

This paper introduces microMap, a nanoscale proximity labeling technique to map intracellular trafficking pathways of CPPs across the BBB using time-gated data.

A claudin5-binding peptide enhances the permeability of the blood-brain-barrier

The paper designs and tests peptides that bind claudin-5 to increase blood-brain barrier permeability, identifying a peptide that effectively enhances permeability in vitro.

Capillary connections between sensory circumventricular organs and adjacent parenchyma enable local volume transmission

The paper identifies portal neurovascular connections between sensory circumventricular organs and adjacent brain tissue, enabling direct diffusible signaling.

Multiregional blood-brain barrier phenotyping identifies the prefrontal cortex as the most vulnerable region to ageing in mice

The paper identifies the prefrontal cortex as the most vulnerable BBB region to ageing in mice by analyzing molecular, structural, and functional changes across three brain regions.

Dietary iron deficiency in the adult mouse increases brain endothelial uptake and blood-brain barrier transport of a high-affinity, anti-transferrin receptor antibody

Zebrafish glial-vascular interactions progressively expand over the course of brain development

This study examines glial-vascular interactions in zebrafish brains across development, showing increasing glial coverage over time, with lower adult coverage compared to mammals.

Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration

This study investigates vascular remodeling in the substantia nigra pars reticulata of rats with chronic neurodegeneration, finding increased vascular density and tortuosity without changes in vessel wall structure.

Advanced Tissue Technologies of Blood-Brain Barrier Organoids as High Throughput Toxicity Readouts in Drug Development

Paraffin histology, multiplex immunofluorescence and MALDI imaging work on blood-brain barrier organoids; an AI apoptosis detector on hematoxylin-eosin slides (F1 0.817 vs pathologists) tracked staurosporine dose responses.

Altered Copper Transport in Oxidative Stress-Dependent Brain Endothelial Barrier Dysfunction Associated with Alzheimer's Disease

This study investigates the role of copper transport proteins in Alzheimer's disease by examining their expression and function in AD mouse models and human brain endothelial cells.

Vascular development of fetal and postnatal neocortex of the pig, the European wild boar Sus scrofa.

The paper quantitatively analyzes the development of cortical vasculature in fetal and postnatal pigs, revealing rapid maturation and early assembly of blood-brain barrier components.

Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis

This study identifies FLRT2 as a critical regulator of venous-mediated angiogenesis and blood-brain barrier formation in the developing mouse CNS.

Pericytes require physiological oxygen tension to maintain phenotypic fidelity.

This study develops a method to culture pericytes under physiological oxygen conditions, preserving their phenotypes and enabling functional studies in health and disease.

Cerebrovascular damage caused by the gut microbe-derived uraemic toxin p-cresol sulfate isprevented by blockade of the epidermal growth factor receptor

This study shows p-cresol sulfate impairs the blood-brain barrier via EGFR activation and demonstrates EGFR blockade prevents this damage in vitro.

Modeling of blood flow dynamics in the rat somatosensory cortex

This study models blood flow dynamics in the rat somatosensory cortex, showing that astrocytic activity causes localized vasodilation and increased blood flow, particularly in capillaries.

Ion and water permeation through Claudin-10b paracellular channels

This study uses Molecular Dynamics simulations to compare ion and water permeability of Cldn10b and Cldn15 paracellular channels, revealing structural determinants of their permeability properties.

Transferrin receptor-mediated transport at the blood-brain barrier is elevated in early development but maintained across adult aging

This study investigates TfR-mediated BBB transport in mice across development and aging, finding elevated transport in early development and stability across adulthood, including in an AD model.

High-throughput glioblastoma-neurovascular assembloids model blood-tumor barrier disruption, tumor reprogramming and therapeutic efficacy

This paper develops a high-throughput BTB assembloid model to study glioblastoma-neurovascular interactions and therapeutic responses, finding that BTB disruption correlates with increased tumor invasiveness and drug resistance.

Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown

This study shows that microglia drive diurnal variation in BBB permeability during inflammation, with increased BBB breakdown following evening LPS injection.