T-cell and B-cell Immunology

Targeting the NuRD Component, CHD4, Impairs Foxp3+ Treg Cell Production and Function and Promotes Anti-Tumor Immunity

This study shows that inhibiting CHD4, a component of the NuRD complex, reduces Treg cells and enhances antitumor immunity without causing autoimmunity.

Neutrophils induce effective antibody responses to the pneumococcal conjugate vaccine by inhibiting regulatory T cells

This study shows that neutrophils suppress regulatory T cells to enhance antibody responses to the pneumococcal conjugate vaccine in mice and humans.

PREMATURE BIRTH AND CESAREAN SECTION AFFECT NEONATAL CD4+ T CELL GENE EXPRESSION AND CELLULAR FUNCTION

The paper examines how premature birth and cesarean section affect neonatal CD4+ T cell gene expression and function, finding that vaginal delivery promotes immune activation while cesarean section restrains it.

Atomistic TCR-ligand interactions shape memory T-cell differentiation

The paper identifies how TCR-ligand interactions influence memory T-cell differentiation by analyzing clonotype-specific signaling and functional outcomes.

Glutamine-Dependent Biosynthetic Pathways Fuel Autoreactive T and B Cells in Foxp3 Deficiency-mediated Disease

This study shows glutamine supports autoimmune disease in Foxp3 deficiency by fueling biosynthetic pathways in T and B cells, with distinct roles in cytokine production and autoantibody formation.

Atherosclerosis destabilizes regulatory T cells (Tregs) resulting in multiple families of exTregs

This study identifies Treg destabilization as a staged differentiation process in atherosclerosis, leading to diverse exTreg states driven by IL-6R signaling.

TCR germline diversity reveals evidence of natural selection on variable and joining alpha chain genes

The paper maps common TCR alleles in 2,668 donors, finds natural selection on TRAJ and TRAV genes, and shows allelic polymorphism affects T cell function.

Multiomics profiling of APECED peripheral blood highlights compositional increases in alternatively activated B cell subsets

This study identifies compositional changes in B cell subsets in APECED patients, highlighting expanded alternatively activated B cells with autoreactive potential.

CD3, CD28, TCRαβ expression and IL-2 production in a spontaneous glycosylphosphatidylinositol-deficient Jurkat T cell line

This study examines the effects of GPI-deficiency on TCR, CD3, CD28 expression and IL-2 production in a GPI-deficient Jurkat T cell line, finding altered surface receptor expression but no significant impairment in IL-2 production under direct pathway activation.

Constitutive androstane receptor directs developing Th1 cells towards the Tr1 lineage

This study shows CAR promotes Tr1 lineage commitment in Th1 cells during intestinal inflammation, with IL-27 and glucocorticoids enhancing this effect.

T cell degranulation and payload delivery are modulated in space and time

This study shows degranulation in T cells is regulated by physical and chemical factors, with insoluble particles transported directionally and CAR T cells having impaired particle centralization.

Distributed Clonal Deletion Prevents Autoimmune Disease Progression

This study shows that distributed clonal deletion checkpoints prevent autoimmune disease by restricting autoreactive B cell diversification and persistence.

A Germinal Center-Independent Innate-Like Memory B Cell Compartment of B1 Origin

The paper identifies a GC-independent memory B cell subset derived from B1 cells that contributes to protective immunity against viral infection.

Distinct systemic and gut IgA responses to bacteria of the human upper gastrointestinal tract

The paper examines systemic and gut IgA responses to bacteria in the human upper gastrointestinal tract, finding distinct reactivity patterns and limited clonal overlap between gut and bone marrow plasma cells.

Human cornea harbors tissue-resident memory T cells shaped by systemic immune activation, age and biological sex

This study identifies tissue-resident memory T cells in the human cornea and shows their abundance is influenced by age, sex, and systemic immune activation.

Combination antagonism of TNF superfamily signaling for T cell immunosuppression

This study evaluates TNF/TNFR combinations for immunosuppression, finding that four drug combinations significantly reduce T cell cytokine production and gene activation in allogeneic responses.

A unified network systems approach uncovers a core novel program underlying T follicular helper cell differentiation

This study identifies a core gene program underlying Tfh cell differentiation using a multi-scale network systems approach, revealing a novel role for IL-12 in regulating Tfh precursor differentiation.

Germinal center-independent memory B cells provide rapid protection from lethal influenza challenges

The paper identifies a durable, diverse GC-independent memory B cell population that provides rapid protection from influenza challenges.

Prohibitin 2 is a Key Regulator of T Cell Proliferation, Differentiation, and Effector Functions in vivo

This study investigates the role of PHB2 in T cell proliferation, differentiation, and effector functions, finding that PHB2 deficiency causes cell cycle arrest and metabolic dysfunction.

TCR-dependent and TCR-independent in-vitro T cell activation generate distinct functional, metabolic, and cytokine programs: Protein kinase C signalling augments anti-CD3+anti-CD28 responses

This study compares TCR-dependent and TCR-independent T cell activation methods, finding distinct functional, metabolic, and cytokine profiles, with PKC signaling enhancing CD3+CD28 responses.

Quorum sensing underlies the establishment and maintenance of marginal zone B cells

This study identifies quorum sensing mechanisms that regulate the establishment and maintenance of marginal zone B cells in mice through developmental and homeostatic processes.

Ageing of the Upper Airway Epithelial Niche Limits Tissue-Resident T Cell Immunity

This study shows that ageing reduces tissue-resident memory T cells in the upper airway, linked to impaired epithelial-immune crosstalk and reduced TGF-β signaling.

Systemic-to-mucosal trafficking of memory B cells contributes to humoral immunity in the upper respiratory tract

The paper shows that systemic memory B cells traffic to mucosal sites in the upper respiratory tract, contributing to local immunity, and that antigen-specific B cells accumulate there only during local inflammation.

Antigenic stimulation in conjunction with cytokine is required for mediating IL-17A production in human MAIT cells

This study shows that IL-23 and TCR stimulation together are needed for lung MAIT cells to produce IL-17A, with distinct transcriptional changes observed.

MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion

This study shows that MEK inhibition reduces mitochondrial dysfunction and terminal CD8+ T cell exhaustion by decreasing nutrient uptake and RNA polymerase II activity.

CXCR6 marks polyfunctional effector CD4 T cells required for anti-Chlamydia immunity in the female reproductive tract

This study identifies CXCR6 as a marker of protective polyfunctional CD4 T cells critical for anti-Chlamydia immunity in the female reproductive tract.

Bcl11b dose-dependently regulates positive selection of CD8 T cells to the virtual memory fate

This study shows that reduced Bcl11b dosage biases CD8 T cells toward the virtual memory fate during positive selection, independent of cytokine pathways.

Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy

This study develops a receptor-tethered orthogonal IL-2 system to enhance Treg persistence and efficacy in autoimmune diabetes, showing improved survival and therapeutic outcomes.

IgA plasma cells co-secrete monomeric and dimeric IgA

The paper shows that IgA plasma cells co-secrete monomeric and dimeric IgA, challenging the idea that distinct subsets produce only one form.

Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis