T-cell and B-cell Immunology

Regulatory T cells restrain cytotoxic and bystander CD8 T cells without compromising antigen-driven memory in mucosal tissue

The paper investigates how regulatory T cells control cytotoxic and bystander CD8 T cell activity in mucosal tissues without affecting antigen-driven memory responses.

Biophysical properties of IgD determine thresholds for self-tolerance and selection into germinal centers

This study shows that IgD's long hinge increases entropic cost in antigen binding, reducing negative selection and raising the threshold for germinal center entry.

Dual Th1 and tissue-repair Treg cells accumulate in skeletal muscle preserving tissue integrity during infection

The paper identifies tissue-adapted Treg cells in skeletal muscle during chronic parasitic infection that balance inflammation and tissue repair.

Thymic Treg-derived T follicular regulatory cells prevent catastrophic humoral autoimmunity in response to TLR7-driven inflammation

This study shows that thymic Treg-derived T follicular regulatory cells prevent autoimmunity by limiting GC responses during TLR7-driven inflammation.

LysoDCs in Peyer's patches program compartmentalized microbiota-specific Th17 responses

The paper shows that Peyer's patch LysoDCs generate microbiota-specific Th17 responses distinct from those in mesenteric lymph nodes, with functional consequences for mucosal immunity.

Sequential infection reprograms the immune landscape to shape future responses

This study shows that sequential infections in mice remodel immune landscapes, making them more similar to human immunity and affecting future immune responses.

Mucosal-associated invariant T cells support IL-15-dependent Treg response in skin injury and promote resolution of skin inflammation

This study identifies MAIT cells as regulators of Treg responses in skin inflammation, showing their ability to resolve inflammation through IL-15-dependent mechanisms.

Uncertainty-aware quantitative analysis of the structure and dynamics of T cell receptor repertoires

This paper introduces ClustIRR, a framework for analyzing T cell receptor repertoire structure and dynamics with uncertainty quantification, demonstrating its application in antigen challenge, cancer immunotherapy, and V(D)J recombination biases.

T cell receptor-ligand affinity quantitatively tunes transcriptome remodelling in vivo, inversely regulating cell division and interferon response

This study shows that TCR-ligand affinity quantitatively modulates transcriptome remodelling in vivo, affecting cell division and interferon response.

Medullary epithelium-free areas in the rat thymus are specialized niches enriched for mature thymocytes and distinct stromal subsets

DextraDemixer enables accurate identification of antigen-specific T cells from pMHC multimer experiments

DextraDemixer improves identification of antigen-specific T cells from pMHC multimer data by using a Bayesian model and dynamic thresholding to reduce false discoveries.

TOX enforces the immunosuppressive program of tumor-infiltrating regulatory T cells

This study identifies TOX as a critical regulator of tumor-infiltrating regulatory T cells, showing its role in maintaining immunosuppression and its potential as a therapeutic target.

Diacylglycerol kinase zeta dictates CD40-mediated immune synapse formation, mTORC1 signaling and plasma cell fate in B lymphocytes

This study shows DGKζ is essential for CD40-mediated immune synapse formation, mTORC1 signaling, and plasma cell differentiation in B cells.

Yin Yang 1-dependent TET2 regulation is essential for early T cell development

This study shows that YY1 REPO domain regulates TET2 expression, which is essential for T cell development, and that disrupting this regulation causes developmental defects.

Human CD8-iTreg are potent GVHD suppressors and tumoricidal effectors by release of Granzyme-K+ Supramolecular Attack Particles

This study identifies CD8-iTreg as potent anti-tumor effectors and GVHD suppressors through Granzyme-K+ supramolecular attack particles.

IL-38 limits alloreactivity through modulating myeloid and T cell activation

This study shows IL-38 reduces monocyte antigen presentation and promotes regulatory T-cell expansion, thereby limiting alloreactivity in GvHD models.

Memory Regulatory T Cells Reprogram into Protective Tfh-like Effectors in Recurrent Malaria

The paper shows memory Tregs reprogram into protective Tfh-like cells during recurrent malaria, enhancing antibody responses and parasite control.

CD8-mediated organization of the TCR-pMHC interface shapes its force response and dissociation pathways

This study uses molecular dynamics simulations to show how CD8 modulates the mechanical stability and dissociation pathways of the TCR-pMHC complex.

Runx/Cbfβ regulates the development of tolerogenic Thetis cells

This study identifies Runx/Cbfβ transcriptional factor complexes as regulators of Thetis cell subset development and Rorγt+ pTreg cell induction.

Cross-species chromatin accessibility pinpoints HIVEP3 as a driver of thymic epithelial maturation and self-antigen expression, preventing chronic inflammation

This study identifies HIVEP3 as a critical regulator of thymic epithelial maturation and self-antigen expression, with its deficiency causing chronic inflammation.

HuBIE: The Human Blood Immunome Encyclopedia Of TCRs and BCRs in Bloodstream Infections and Cancer

HuBIE provides a large-scale immune-repertoire dataset from 1,941 participants, revealing ethnic and age-related differences in TCR and BCR diversity and linking immunological diversity to survival in elderly patients.

Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors

The paper identifies Trim28 as a regulator of CD8 T cell differentiation in tumors using clonally-resolved CRISPR screens and shows its role in maintaining TCF7+ stem-like cells while impairing effector differentiation.

NKG2C+CD27- Defines Human CD8+ Regulatory T Cells

The paper identifies NKG2C+CD27- as a novel marker for CD8+ regulatory T cells, revealing their clonality and functional subsets, and highlights their heterogeneity in aging.

Maintenance of immune tolerance during aging requires competitive expansion of memory phenotype regulatory T cells

Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases

This study identifies two distinct Treg states in RA synovial tissues using scRNA-seq, showing one is dysfunctional and reversible through TNFR2 engagement.

Temporally overlapping mechanisms diversify clonal B cell responses in vivo.

Single-cell RNA and BCR sequencing of infected mouse spleens shows class switching overlaps clonal expansion, GC-seeding clones also form plasmablasts, and SHM proceeds at constant rate.

Cell Cycle Sensing Shapes Human T Cell Fate and Exhaustion Programs

This study investigates how cell cycle dynamics influence T cell fate and exhaustion by analyzing single-cell data and manipulating cell cycle progression and signaling.

The αβTCR repertoire at scale in the immgenT dataset

The paper analyzes the αβTCR repertoire across 734 mouse samples to uncover patterns in TCR diversity, non-random joining, and clonal expansion.

SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells

This study identifies SATB1 as a regulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells, showing its potential as a target for CAR T cell therapy.

Lifelong self-renewal and competition shape the virtual memory CD8 T-cell compartment during aging

This study shows that lifelong self-renewal and competition shape the aging of virtual memory CD8 T cells, leading to a dominance of long-lived resident cells.