Neurogenesis and neuroplasticity mechanisms

Tracing Early Migratory Neurons in the Developing Nose Using Contactin-2 (Cntn2)CreERT2

The paper introduces an inducible Cntn2CreERT2 mouse line to trace and manipulate early migratory neurons in the developing nose.

YAP/TAZ create a physical niche for the maintenance of adult neural stem cell quiescence

The paper shows that BMP4-induced ECM secretion by quiescent NSCs triggers YAP/TAZ to maintain quiescence through fractone preservation.

Altered epithelial development of the lateral ventricle choroid plexus in Mllt11 mutants

This study investigates the role of Mllt11 in choroid plexus development by analyzing its effect on neuroepithelial progenitor migration and epithelial architecture in mutant mice.

Dendritic Polyglycerol Amine Substrate Extends the Viability of Mixed Glial Cultures for Repeated Isolation of Immature Oligodendrocyte Lineage Cells

This study shows that dPGA-coated substrates support longer-term mixed glial cultures, enabling repeated isolation of immature oligodendrocyte lineage cells compared to PDL-coated substrates.

APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids

This study shows APOE4 affects cortical neurodevelopment and network formation in human brain organoids by altering cell types, increasing cell death, and disrupting GABA signaling.

In mice, discrete odors can selectively promote the neurogenesis of sensory neuron subtypes that they stimulate

The paper shows that specific odors can increase the birth rates of olfactory sensory neuron subtypes they activate in mice.

Morphodynamics of human early brain organoid development

The paper uses live imaging and single-cell transcriptomics to study how extracellular matrix influences brain organoid development and regionalization.

TNF-α-induces type I IFN signalling to suppress neurogenesis and recruit T cells

This study identifies TNF-α-induced type I IFN signaling as a mechanism suppressing neurogenesis and recruiting T cells in human hippocampal progenitor cells.

DSCAM preserves neuronal order during radial migration by antagonizing N-Cadherin adhesion and UNC5c repulsion

This study shows DSCAM maintains neuronal order during radial migration by inhibiting N-Cadherin adhesion and UNC5c repulsion, preserving migratory sequence in developing cortical neurons.

Directional growth of developing myelin mediated by Wnt gradient and required for proper axon functions

This study shows that directional myelin growth in zebrafish is driven by a Wnt4b gradient and is essential for proper axon function and behavior.

Sequential transcriptional programs underpin activation of quiescent hippocampal stem cells.

The paper identifies sequential transcription factor programs that govern the activation of quiescent hippocampal stem cells through single-cell transcriptomic analysis in mice.

The density of doublecortin cells in the piriform cortex is affected by transition to adulthood but not first pregnancy in female mice

The paper examines how aging and motherhood affect immature neuron density in the piriform cortex of female mice, finding age-related decreases but no significant changes due to first pregnancy.

Multi-omics identification of extracellular components of the fetal monkey and human neocortex.

The paper identifies extracellular components in the developing fetal neocortex of humans and non-human primates using multi-omics approaches.

Novel insights into Emx2 and Dmrta2 cooperation during cortex development and evidence for Dmrta2 function in choroid plexus

This study investigates the cooperative role of Emx2 and Dmrta2 in cortex development and reveals distinct functions of Dmrta2 in choroid plexus formation.

Multimodal Validation of the Existence of Transitional Cerebellar Progenitors in the Human Fetal Cerebellum

The paper validates the existence of transitional cerebellar progenitors using multimodal approaches across multiple datasets and stages.

A Novel Method for Culturing Telencephalic Neurons in Axolotls

This study develops a novel in vitro culture protocol for axolotl telencephalic neurons, demonstrating their viability, functionality, and responsiveness to injury.

The mGluR5 Agonist, CHPG, Enhances Numbers of Differentiated Human Oligodendrocytes

This study shows that CHPG increases differentiation of human oligodendrocyte precursor cells and upregulates mGluR5 in MS astrocytes, suggesting potential therapeutic applications.

Post-replicative initial expression of the cell fate regulator PAX6 during neuroectoderm differentiation

The paper shows PAX6 expression occurs post-replicatively during neuroectoderm differentiation, coupling NPC fate to cell cycle progression after DNA replication.

Structural innovations and neurogenic continuity define avian brain development and evolution

This study presents a single-cell and spatial transcriptomic atlas of the budgerigar brain, revealing structural and developmental insights into avian neurogenesis and brain evolution.

Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors

The paper shows that a sequence of transcription factors drives the chronological diversification of spinal neuron subtypes in motor and sensory circuits.

Efficient Generation of Expandable Dorsal Forebrain Neural Rosette Stem Cell Lines

This study presents a method to generate pure and expandable neural rosette stem cell lines without manual isolation, demonstrating their differentiation potential and scalability for clinical applications.

Early Indirect Neurogenesis transitions to late Direct Neurogenesis in mouse cerebral cortex development

The paper challenges the established model of cortical neurogenesis by showing indirect neurogenesis predominates early and shifts to direct neurogenesis later in mouse cerebral cortex development.

Lineage Analysis and Molecular Characterization of Bergmann Glia-like Progenitors in the Postnatal Mouse Cerebellum using in vivo Electroporation and Spatial Transcriptomics

This study characterizes Bergmann glia-like progenitors (BGLPs) in the postnatal mouse cerebellum using electroporation and spatial transcriptomics, revealing their developmental dynamics and gene expression profiles.

Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons

The paper identifies mammalian-specific gene regulatory elements and their role in neocortical neuron subtype diversity and connectivity, linking them to neurodevelopmental disorders.

CCN1 forms a complex with GPC4 and heparin to fine-tune signaling activities for embryonic cortical neural stem cell maintenance

The paper shows CCN1 interacts with GPC4 and heparin to regulate NSC maintenance via the Shh pathway in embryonic cortical development.

Alcohol Use Disorder Associated Gene FNDC4 Alters Glutamatergic and GABAergic Neurogenesis

The paper identifies FNDC4 as a gene associated with alcohol use disorder through GWAS and shows its role in regulating neurogenesis via alternative splicing and CRISPR/Cas9 experiments.

CRITICAL ROLE OF ADULT-BORN DENTATE GRANULE NEURONS IN PATTERN COMPLETION

The paper shows adult-born dentate granule neurons contribute to pattern completion, a process critical for episodic memory, with implications for mental health disorders.

A human-specific enhancer fine-tunes radial glia potency and corticogenesis

The paper shows human-specific variants in HARE5 enhance enhancer activity, promoting progenitor proliferation and contributing to human cortical expansion.

Molecular states underlying neuronal cell type development and plasticity in the whisker cortex

The paper constructs a single-nucleus transcriptomic atlas of the mouse whisker somatosensory cortex during development and finds that sensory experience minimally affects cell type maturation in this region, unlike the visual cortex.

DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change

The paper identifies a human-specific mutation in DCHS1 that alters glycosylation and affects forebrain proportions by changing striatal and neocortical progenitor ratios.