Neurogenesis and neuroplasticity mechanisms

Transient disruption of progenitor states and layer 2/3 projection neuron generation in frontal association cortex due to 22q11.2 gene deletion

This study identifies transient disruptions in progenitor states and layer 2/3 neuron generation in the frontal cortex of a 22q11DS mouse model, linking these changes to schizophrenia risk.

An atlas of shark developing telencephalon reveals ancient origin of basal progenitors and Cajal-Retzius cells

This study uses single-cell and spatial transcriptomics to analyze shark telencephalon development, revealing ancient origins of basal progenitors and Cajal-Retzius cells in gnathostomes.

Spatially Organized IGF1 mTOR Signaling Controls Human Forebrain Progenitor Fate Through Coordinated Transcriptional and Translational Programs

This study identifies a spatially organized IGF1-mTOR signaling mechanism in human forebrain progenitors that regulates proliferation and fate through transcriptional and translational control.

Early Emergence of Projection-subtype fate-restricted Radial Glial Progenitors Orchestrates Neocortical Neurogenesis.

The paper reveals that early multipotent radial glial progenitors generate all projection neurons through parallel sublineages and fate-restricted daughter cells, challenging existing models of cortical development.

METTL9 sustains vertebrate neural development primarily via non-catalytic functions

The paper investigates METTL9's role in vertebrate neural development, finding its non-catalytic functions sustain neurogenesis through secretory pathway modulation.

Astrocyte-derived PTPRZ1 regulates astrocyte morphology and excitatory synaptogenesis

This study shows that PTPRZ1 in astrocytes is crucial for their morphology and excitatory synaptogenesis, using a conditional knockout mouse model.

Isolation of Neural Stem Cells Using Platelet Derived Growth Factor C

This study shows that PDGFC supports the isolation of quiescent murine neural stem cells, which can be induced to proliferate with EGF/FGF and transition to oligodendrocyte progenitor cells.

Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2

This study identifies meningeal-derived retinoic acid's role in suppressing Notch and Sox2 to regulate neurogenesis in neocortical progenitors.

Transcription factor LHX2 suppresses astrocyte proliferation in the postnatal mammalian cerebral cortex

This study shows that loss of Lhx2 increases astrocyte proliferation in upper cortical layers and induces reactive gliosis-like signatures without injury.

HPDL is critical in human cortical development via regulation of mitochondrial functional properties

This study shows HPDL is essential for cortical development by regulating mitochondrial function and neurogenesis, with implications for SPG83 pathology and potential antioxidant therapies.

Diversification of Dentate Gyrus Granule Cell Subtypes is Regulated by Neuregulin1 Nuclear Back Signaling.

The paper identifies a role for Neuregulin1 nuclear back signaling in regulating dentate gyrus granule cell subtype diversity, showing that its disruption leads to increased semilunar granule cell-like cells.

Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer Neurogenesis

This study shows thalamic NRXN1 signaling promotes human cortical upper-layer neurogenesis by interacting with outer radial glia.

Multisensory gamma stimulation enhances adult neurogenesis and improvescognitive function in male mice with Down Syndrome

This study shows that multisensory gamma stimulation improves cognitive function and adult neurogenesis in Ts65Dn mice, a model of Down syndrome.

Charting the transition from in vitro gliogenesis to the in vivo maturation of transplanted human glial progenitor cells

This study tracks the in vitro generation and in vivo differentiation of human glial progenitor cells using single-cell RNA and ATAC-seq, revealing how the host environment influences their maturation into astrocytes and oligodendrocytes.

Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner

The paper shows that Hmgb2 enhances astrocyte-to-neuron conversion by regulating chromatin accessibility of neuronal maturation genes in response to growth factors.

Early life growth and cellular heterogeneity in the short-lived African turquoise killifish telencephalon

This study maps the telencephalon growth and cellular diversity in the African turquoise killifish during early post-embryonic development, identifying dynamic neurogenic niches and spatial differences in growth patterns.

Differential contribution of P73+ Cajal-Retzius cells and Reelin to cortical morphogenesis

The paper investigates the role of P73+ Cajal-Retzius cells and Reelin in cortical morphogenesis, finding that CRs-derived Reelin is essential for radial migration arrest, while CRs also have Reelin-independent functions in hippocampal progenitor proliferation and vessel remodelling.

A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellum

The paper identifies FOXO1 as a key regulator of inhibitory neuron differentiation in mouse and human cerebellar progenitors, showing its conservation and regulation by WNT signaling.

Heterochronic scaling of neurogenesis for species-specific dosing of cortical excitatory subtypes

The paper shows that species-specific differences in cortical excitatory neuron subtypes arise from non-uniform scaling of neurogenesis timing, regulated by Wnt signaling in rats.

DTX4 regulates neural progenitor transitions during cortical development

This study identifies DTX4 as a regulator of neural progenitor transitions during cortical development, showing its role in maintaining radial glia identity and preventing intermediate progenitor generation.

UBE3C links ubiquitin signaling to epitranscriptomic control of cortical neurogenesis

The paper shows UBE3C regulates cortical neurogenesis and glial fate through m6A methylation, with mutations disrupting this process and offering therapeutic targets.

Developmental overproduction of cortical superficial neurons impairs adult auditory cortical processing

This study shows that overproduction of cortical superficial neurons in mice impairs auditory processing and behavior in adulthood.

Enriched environmental intervention mitigates hippocampal cellularity and behavioral disorders in maternal protein-restricted male rat offspring

This study shows that maternal protein restriction during pregnancy and breastfeeding reduces hippocampal neurons and behavioral issues in male rat offspring, but an enriched environment can reverse these effects.

Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis

The paper integrates single-cell transcriptomics and epigenomics to show how neural stem cells shift lineage bias and epigenetic states during mouse corticogenesis.

Oligodendrocyte precursor cells establish contacts with somata of active neurons

The paper shows that oligodendrocyte precursor cells (OPCs) form contacts with active neurons, reducing their calcium signals and thereby regulating neuronal activity.

Fate plasticity of interneuron specification

This study shows that the identity of MGE-derived cortical interneurons can be dynamically influenced by their environment, with human 3D models promoting Pvalb expression over Sst.

Krüppel Regulates Cell Cycle Exit and Limits Adult Neurogenesis of Mushroom Body Neural Progenitors in Drosophila

This study identifies Krüppel as a regulator of cell cycle exit in Drosophila mushroom body neuroblasts, showing its role in limiting adult neurogenesis and its interaction with other transcription factors.

Timing Matters: Lessons from Perinatal Neurogenesis in the Olfactory Bulb

The paper investigates how the timing of granule cell neurogenesis in the olfactory bulb influences their anatomical distribution and synaptic integration with projection neurons.

Neotenic expansion of adult-born dentate granule cells reconfigures GABAergic inhibition to enhance social memory consolidation

The paper shows that expanding immature adult-born dentate granule cells in mice enhances GABAergic inhibition and improves social memory consolidation.

Alzheimer's Disease Mutations Disrupt Neural Stem Cell Fate and Early Brain Development

This study shows AD mutations impair neural stem cell fate and early brain development, leading to structural vulnerabilities that may increase AD risk later in life.