Neurogenesis and neuroplasticity mechanisms

Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans

The paper compares gene expression in immature neurons across species to identify human-specific features and shared biological processes.

Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1

The paper shows microglia regulate GABAergic neurogenesis in the prenatal human brain via IGF1, using single-cell transcriptomics and organoid models.

Wntless interacts with Notch signaling to balance the generation of neurons and gliocytes in vertebrate dorsal diencephalon

The paper shows that Wntless restricts Notch signaling to balance neuron and gliocyte generation in zebrafish dorsal diencephalon.

Geometric principles determining the morphology of oligodendrocyte precursor cells in brain white matter

The paper investigates the geometric principles governing the morphology of oligodendrocyte precursor cells (OPCs) in the mouse corpus callosum using imaging and morphometric analysis.

Transformation of an olfactory placode-derived cell into one with stem cell characteristics by disrupting epigenetic barriers

The paper shows that disrupting epigenetic barriers in olfactory placode-derived cells can induce stem cell-like characteristics through genetic perturbations.

CCB79 is a primate-specific cilium initiation factor essential to maintain neural progenitor diversity in developing brain tissue.

This study identifies CCB79 as a primate-specific protein essential for maintaining neural progenitor diversity in developing brains by regulating ciliogenesis.

Mature interneuron subtypes arise from distinct spatial and temporal subdomains within the caudal ganglionic eminence

The paper investigates the spatial and temporal origins of interneuron subtypes in the caudal ganglionic eminence (CGE) and shows that specific subtypes arise from distinct CGE subdomains with stable spatial biases over time.

Sox5 controls the establishment of quiescence in neural stem cells during postnatal development

This study identifies Sox5 as a regulator of quiescence in neural stem cells during postnatal development, showing its role in balancing primed and deep quiescence to maintain adult neurogenesis.

F-BAR proteins CIP4 and FBP17 function in cortical neuron radial migration and process outgrowth

This study shows that CIP4 and FBP17 regulate radial neuron migration and neurite outgrowth in the developing cortex by modulating neuronal morphology.

Unraveling Regulatory Feedback Mechanisms in Adult Neurogenesis Through Mathematical Modelling

This study uses mathematical models to analyze regulatory feedback mechanisms in adult neurogenesis, finding that neural stem cells predominantly regulate lineage dynamics.

Role of oligodendroglial ADAM10 in oligodendrocyte maturation, myelination and myelin maintenance

This study investigates the role of oligodendroglial ADAM10 in myelin development and maintenance, finding that its deficiency causes delayed oligodendrocyte maturation and myelin defects with sexual dimorphism in adult mice.

PV - Oligodendrocyte Interactions in the Infralimbic Cortex Promote Extracellular Plasticity after Safety Learning

The paper shows safety learning in the infralimbic cortex recruits oligodendrocyte progenitor cells to PV interneurons, promoting PNN degradation and cognitive flexibility.

DNMT1-Mediated Regulation of Somatostatin-positive Interneuron Migration Impacts Cortical Architecture and Function

This study shows that DNMT1 regulates the migration of somatostatin-expressing interneurons, affecting cortical layer structure and function in mice.

Characterizing Oligodendrocyte-Lineage Cells and Myelination in the Basolateral Amygdala: Insights from a Novel Methodology in Postmortem Human Brain

This study develops a method to isolate oligodendrocyte-lineage cells from postmortem brain tissue and finds age-related gene expression changes and a correlation between oligodendrocyte density and myelin area in the basolateral amygdala.

TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination

This study identifies TMEM63A as a critical regulator of myelination in the CNS, showing its role in oligodendrocyte function and linking its dysfunction to hypomyelinating leukodystrophies.

Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemia

The paper identifies Thbs4-positive astrocytes from the SVZ that modulate the extracellular matrix at the glial scar after brain ischemia by synthesizing and degrading hyaluronan.

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

This study identifies a global temporal chromatin programme in vertebrate neural progenitors that integrates with spatial patterning to regulate cell fate and identity.

A postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons

This study identifies a molecular switch driven by neuronal activity and PGC-1 that promotes the maturation of parvalbumin interneurons during postnatal development.

Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells

The temporal analysis of gene regulatory networks in human neural stem cells reveals multiple early critical phases associated with cortical disorders and neuropsychiatric traits.

Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially Impact Schwann and Olfactory Ensheathing Cell Development Without Disrupting GnRH-1 Migration

The paper investigates the role of Yap and Taz in OEC and Schwann cell development using single-cell RNA sequencing and conditional ablation in mice, finding differential impacts without affecting GnRH-1 migration.

Methyl gallate Attenuates Post-Stroke Emotional and Cognitive Symptoms by Promoting Hippocampal Neurogenesis via PI3K/GSK3 and AMPK Signaling

This study shows that methyl gallate improves post-stroke depression and cognitive impairments by enhancing hippocampal neurogenesis through PI3K/GSK3 and AMPK signaling.

GPR17 modulates oligodendrocyte precursor cell maturation during development but has limited impact on myelin regeneration following demyelinating insults

This study investigates GPR17's role in oligodendrocyte precursor cell maturation and myelin regeneration, finding limited impact on myelin repair after injury.

Two parallel lineage-committed progenitors contribute to the developing brain

The paper identifies two lineage-committed progenitors in the developing brain that generate forebrain/midbrain and hindbrain regions, and demonstrates their distinct chromatin landscapes and differentiation potential.

Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits in SLC6A1 Deficient Interneurons

This paper develops a method to generate MGE organoids from hPSCs that robustly produce PV-expressing interneurons and reveals migration deficits in SLC6A1-deficient interneurons.

Autism-associated oxysterol regulates GABAergic neurogenesis and subtype fates

The paper shows that 24S,25-epoxysterol, an oxysterol linked to neurodevelopmental disorders, promotes neurogenesis and disrupts GABAergic neuronal subtype composition through the liver X receptor pathway.

The chloride cotransporter NKCC1 regulates self-renewal of hippocampal neural stem cells via the transcription factor Sox11

This study shows that NKCC1 regulates hippocampal neural stem cell self-renewal via Sox11, with reduced NKCC1 in aging promoting symmetric division and decreased neurogenesis.

Functional maturation and experience-dependent plasticity in adult-born olfactory bulb dopaminergic neurons

This study examines the functional maturation and experience-dependent plasticity of adult-born dopaminergic neurons in the olfactory bulb of mice, finding they rapidly acquire mature properties and show limited plasticity.

α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

This study shows that α7 nicotinic acetylcholine receptors influence radial glia fate in human cortical development, with nicotine exposure altering neuronal differentiation and RG proliferation.

Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence

The paper shows Notch signaling epigenetically primes neural progenitors to enhance Sonic Hedgehog signaling and promote oligodendrocyte differentiation in the developing mouse forebrain.

Hypermyelination Improves Strength and Detection of Neuronal Activity in the CA1 Hippocampus and Facilitates Neuroprotection in FusOLcKO Mice

This study shows that hypermyelination in FusOLcKO mice enhances hippocampal neuronal activity detection but disrupts cortical network communication.