Pancreatic function and diabetes

Regenerating insulin-producing β-cells ectopically from a mesodermal origin in the absence of endothelial specification

This study shows that mesodermal cells can differentiate into insulin-producing β-cells without endothelial specification, revealing a new pathway for β-cell regeneration in zebrafish.

H3K4 trimethylation is required for postnatal pancreatic endocrine cell functional maturation

This study shows that H3K4 trimethylation is necessary for the functional maturation of pancreatic islet endocrine cells by activating genes involved in glucose-stimulated insulin secretion.

Direct reprogramming of human fibroblasts into insulin-producing cells by transcription factors

This study shows that human fibroblasts can be directly reprogrammed into insulin-producing cells using a specific transcription factor cocktail.

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

This study maps NEUROG3 occupancy in human pancreatic endocrine progenitors, identifying 1268 target genes and linking NEUROG3 to islet cell development and type 2 diabetes risk variants.

Hnf1b-CreER causes efficient recombination of a Rosa26-RFP reporter in duct and islet δ cells

The paper evaluates the Hnf1b-CreERT2 reporter system in adult pancreatic duct and δ cells, finding high recombination efficiency in duct cells but low in β cells and partial activation in δ cells.

A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β-cells

The paper identifies a micropeptide encoded by a long noncoding RNA that regulates pancreatic β-cell function and insulin secretion.

Integrated transcriptomics identifies β-cell subpopulations and genetic networks associated with obesity and glycemic control in SM/J mice

This study integrates single-cell and bulk RNA sequencing data from SM/J mice to identify β-cell subpopulations and genetic networks linked to obesity and glycemic control.

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes

This study uses multi-omics analysis of pancreatic islet donors to show heterogeneous beta cell changes associated with type 2 diabetes progression.

Decreased KATP channel activity contributes to the low glucose threshold for insulinsecretion in the early postnatal period

The paper shows that decreased KATP channel surface density in early postnatal rat beta-cells lowers the glucose threshold for insulin secretion, which normalizes by postnatal day 14.

The Anna Karenina model of beta cell maturation in development and their dedifferentiation in type 1 and type 2 diabetes

The paper tests two models of beta cell dedifferentiation in diabetes using lineage tracing and RNA-seq in mice, showing dedifferentiation is not a reversal of development but varies by diabetes type.

Early postnatal activation of the hypoxia pathway disrupts β-cell function

This study shows that early postnatal activation of the HIF1A pathway in rats causes hyperinsulinism and reduced β-cell proliferation, potentially increasing diabetes risk.

Mouse Single Islet β Cell Transcriptomics Reveal Sexually Dimorphic Transcriptomes and Type 2 Diabetes Genes

This study identifies sexually dimorphic transcriptomes in mouse β cells and sex-dependent type 2 diabetes genes using scRNA-seq, highlighting sex differences in diabetes pathogenesis.

An organ-based multi-level model for glucose homeostasis: organ distributions, timing, and impact of blood flow

The paper updates a multi-level mathematical model of glucose homeostasis to better reflect organ-specific glucose uptake, dynamics, and the impact of blood flow on insulin-stimulated glucose uptake.

Structural effects driven by rare point mutations in amylin hormone, the type II diabetes-associated peptide

The paper investigates the structural effects of two rare point mutations in amylin, finding both mutations affect aggregation potential and suggest therapeutic implications for type II diabetes.

A multi-scale in silico mouse model for insulin resistance and humanoid type 2 diabetes

The paper presents an in silico mouse model that simulates multi-scale insulin resistance and type 2 diabetes progression across cells, organs, and the whole body.

Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes

This study identifies glucocorticoid-responsive gene regulatory programs in pancreatic islets and links them to type 2 diabetes risk through chromatin and gene expression analysis.

Elucidating the crosstalk between inflammation and DNA damage pathways in the pancreatic beta-cell through the diabetes susceptibility gene, TCF19

This study investigates the effects of TCF19 overexpression in pancreatic beta-cells, revealing increased DNA damage response and inflammatory gene expression.

Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes risk

The paper uses single-cell chromatin accessibility to identify cell type- and state-specific regulatory programs associated with type 2 diabetes risk.

Perilipin2 down-regulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria

This study shows that reducing Perilipin2 in beta cells impairs insulin secretion and mitochondrial function under nutritional stress.

Machine learning algorithms in big data analyses identify determinants of insulin gene transcription

The paper compares 10 machine learning workflows to identify genes associated with insulin transcript presence in human pancreatic single-cell transcriptomes, finding Random Forest to be highly predictive.

Generation of a novel Nkx6-1 Venus fusion reporter mouse line

This paper generates a Nkx6-1 Venus fusion reporter mouse line to track and isolate Nkx6-1-expressing cells, including pancreatic β-cells, during development and in adult tissues.

The transcriptional repressor REST is a major negative regulator of endocrine differentiation during pancreas organogenesis

The paper shows REST inhibits pancreatic endocrine differentiation in mice, zebrafish, and human organoids, identifying it as a key negative regulator.

A pro-endocrine pancreatic transcriptional program established during development is retained in human gallbladder epithelial cells

The paper shows human gallbladder epithelial cells retain a pro-endocrine pancreatic transcriptional program, enabling insulin production and immune protection in type 1 diabetes.

PDX1 directs a core developmentally and evolutionarily conserved gene program in the pancreatic islet

The paper identifies a core set of developmentally and evolutionarily conserved PDX1-bound genes in mouse and human pancreas development, showing stable PDX1 binding across ages with context-dependent regulatory roles.

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

The paper identifies T2D risk variants in pancreatic progenitor-specific enhancers and shows their role in regulating developmental genes involved in pancreas morphogenesis.

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

This study investigates the role of C2cd4b in murine glucose homeostasis, revealing sexually dimorphic effects on body weight and glucose tolerance.

Single-cell transcriptome lineage tracing of human pancreatic development identifies distinct developmental trajectories of alpha and beta cells

This study uses single-cell RNA-seq and mitochondrial variants to trace lineage differences between alpha and beta cells in human pancreatic development, revealing distinct developmental trajectories not seen in mice.

Morphogenesis of the islets of Langerhans is guided by extra-endocrine Slit2/3 signals

This study identifies Slit2/3 signals from pancreatic mesenchyme as guiding factors for islet morphogenesis by repelling β cells.

SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β-cells

This study shows that SIX2 and SIX3 regulate functional maturity and fate of human pancreatic β-cells, with SIX2 affecting insulin processing and glucose sensing, and SIX3 influencing gene expression patterns.

Could TDX-1 explain the changes observed in endocrine pancreas due to chronic cola drink consumption in rats? A global point of view

This study investigates the effects of chronic cola consumption on rat pancreatic islets, finding increased PDX-1 expression and reduced beta-cell area, suggesting TDX-1's role in islet dynamics.