Proteoglycans and glycosaminoglycans research

Synovial fluid glycosaminoglycans signature involved 3-O-sulfated heparan sulfate modulated by TGF-β pathway in OA

This study identifies 3-O-sulfated heparan sulfate in OA synovial fluid and shows its regulation by the TGF-β pathway in fibroblastic-like synoviocytes.

Rethinking Syndecan-1 as a Marker of Trauma-Induced Endothelial Injury

This study maps syndecan expression across tissues and challenges SDC1 as a specific endothelial biomarker, showing its epithelial enrichment and potential role in trauma-induced injury.

Precision Targeting of Heparan Sulfate Proteoglycans Broadly Dysregulates Survival Signaling and Metabolic Adaptation in Pancreatic Cancer

This study shows that targeting heparan sulfate proteoglycans in pancreatic cancer with bacterial heparinase III reduces survival signaling and metabolic adaptation, potentially improving therapy efficacy.

A High Throughput SPR-Based Array for Quantitative Profiling of Glycosaminoglycan Protein Interactions

The paper introduces a high-throughput SPR array to profile GAG-protein interactions, validating it with known proteins and identifying new interactions.

Hierarchical control of remyelination by heparan sulfate sulfation

This study identifies hierarchical control of remyelination by heparan sulfate sulfation patterns, showing that 2-O sulfation suppresses BMP and WNT signaling to promote remyelination.

A role for heavy chain-modification in protecting hyaluronan from free radical fragmentation during inflammation

This study shows that covalent attachment of heavy chains to hyaluronan protects it from ROS-induced fragmentation during inflammation.

Hyaluronan Surface Architecture Dictates Colorectal Cancer Progression and Extracellular Vesicle Communication

This study shows that HA surface architecture changes with CRC progression, affecting EV communication and cell behavior, and can be reversed with exogenous HA.

A non-canonical EZH2/TRIM28 epigenetic axis drives heparan sulfate remodeling and melanoma metastasis

This study identifies an EZH2/TRIM28 epigenetic axis that regulates heparan sulfate remodeling and promotes melanoma metastasis.

Immunomodulation of the Innate Host Response by Mesenchymal-Derived Versican during Influenza A Virus Infection

This study investigates the role of mesenchymal-derived versican in modulating the innate immune response during influenza A virus infection, showing its critical role in immune cell migration and adhesion.

Loss of Syndecan-3 Drives a Pro-inflammatory, EndMT-prone Phenotype in Aortic Valve Endothelial Cells

This study identifies syndecan-3 as a regulator of inflammation and EndMT in aortic valve endothelial cells, showing its role in suppressing NF-kappaB activation and mesenchymal transition.

Identification of a novel anti-angiogenic regulatory sequence within the syndecan-3 extracellular core protein.

The paper identifies and characterizes a novel anti-angiogenic peptide, QM111, derived from the syndecan-3 extracellular domain, showing comparable anti-angiogenic activity to QM107.

Hyaluronidase isoforms can promote or suppress glioma invasion within 3D Hyaluronic Acid Matrices

This study shows HYAL1 suppression in glioma cells increases invasion by altering ROS levels and adhesion molecule expression in 3D hyaluronic acid matrices.

Hyaluronan and skin elasticity: Are subterranean mammals special?

The paper investigates whether subterranean mammals have more elastic skin due to elongated hyaluronan polymers, but finds no consistent evidence for this and suggests previous studies may have conflated elasticity with skin looseness.

CRISPR activation screens identify core protein-dependent regulation of heparan sulfate sulfation and ligand specificity

The paper uses CRISPR activation screens to identify proteoglycan core proteins, particularly SDC1, as key regulators of heparan sulfate sulfation and ligand specificity.

Hyaluronic Acid Plays Differential Molecular Weight and Concentration Dependent Pathway Centric Changes to Human Lung Derived Microvascular Endothelial Cells in Culture

This study investigates how different molecular weights and concentrations of hyaluronic acid (HA) affect signaling pathways in human lung microvascular endothelial cells, revealing distinct molecular and functional responses.

A long-chain heparan sulfate capture mechanism directs paracrine GDNF-GFRα1 signalling through RET

The paper reveals how long-chain heparan sulfate (HS) facilitates paracrine GDNF-GFRα1 signaling by forming a multi-protein complex with RET, essential for signaling in trans but not in cis.

The hyaluronan receptor CD44 drives COVID-19 severity through its regulation of neutrophil migration

This study shows that blocking CD44, a hyaluronan receptor, reduces inflammation and improves survival in mice infected with SARS-CoV-2.

Label-Free Determination of Chondroitin Sulphate from Microgram Quantities of Human Milk

This paper develops a method to quantify chondroitin sulphate disaccharides from 25 microliters of human milk, enabling analysis of small-volume samples previously inaccessible to GAG profiling.

The development of ToF-SIMS for in-situ glycosaminoglycan analysis

This paper develops ToF-SIMS for in-situ GAG analysis, identifying discriminatory ions and demonstrating its application in human and diabetic mouse models.

Label-free GAG disaccharide analysis by HILIC-MS/MS for studying diverse biological sample types

The paper introduces a streamlined method for analyzing GAG disaccharides using HILIC-MS/MS, applicable to diverse biological samples.

Heparan sulfate is essential for Drosophila FGF export

The paper shows that heparan sulfate proteoglycans are essential for exporting Drosophila FGF ortholog Branchless to the cell surface.

Quantitative Mapping of Sulfation, Iduronic Acid, and Secondary Structure in Glycosaminoglycans

The paper uses molecular dynamics simulations to study how sulfation and monosaccharide composition affect GAG secondary structures and introduces a classification metric.

Glycoinformatic profiling of label-free intact heparan sulfate oligosaccharides

The paper develops a mass spectrometry-based glycoprofiling approach for native heparan sulfate oligosaccharides, revealing distinct HS profiles in kidney disease patients.

A genome-wide CRISPR screen reveals cancer-specific regulators of hyaluronan binding and cellular invasion

This study uses a CRISPR screen to identify genes regulating CD44-HA binding in breast cancer, revealing RAB4A as a novel regulator of invasion and potential therapeutic target.

Chondroitin 4-sulphate depletion enhances synaptic plasticity and memory in aging

This study shows that reducing chondroitin-4-sulfation in mice improves cognitive function and mitigates age-related decline without removing CSPGs.

Heparan sulfate-function is essential for Integrin-dependent cell-matrix interactions and regulates glycosaminoglycan synthesis synthesis through YAP

This study shows that heparan sulfate (HS) is critical for integrin-mediated cell-matrix interactions and regulates glycosaminoglycan (GAG) synthesis through YAP signaling in chondrocytes.

Mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation

This study shows that mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation through interactions with heparan sulfate proteoglycans.

Structural basis for human chondroitin sulfate chain polymerization

This study identifies four heterodimeric complexes involved in human chondroitin sulfate chain polymerization and proposes a non-processive, disruptive mechanism based on structural and functional analyses.

A Novel Role of Hyaluronan and its Membrane Receptors, CD44 and RHAMM in Obesity-Related Glomerulopathy

This study identifies HA and its receptors CD44/RHAMM as key drivers of obesity-related glomerulopathy, showing their role in renal inflammation, fibrosis, and dysfunction, and suggests they as therapeutic targets.

Genetic and preclinical evidence implicating chondroitin sulfate as a matritherapeutic target for the treatment of type 2 diabetes

This study identifies chondroitin sulfate as a potential therapeutic target for type 2 diabetes through genetic and preclinical evidence showing its effects on glycemic control and insulin action.