NF-κB Signaling Pathways

Rare and novel RELA variants are common in systemic autoimmunity

The paper identifies rare RELA variants in autoimmune diseases and shows they affect NF-κB and IFNβ transcriptional activity and immune cell subsets.

TRAF6 coiled-coil domain mediates its trimerization

This study identifies the trimeric structure of TRAF6's coiled-coil domain using biophysical methods and computational tools.

NF-kappaB is a Central Regulator of Hypoxia-Induced Gene Expression

The paper identifies NF-kappaB-dependent gene expression changes under hypoxia, showing its role in repression of hypoxia-downregulated genes and regulation of oxidative phosphorylation.

Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB

This study identifies truncating RELA variants causing autoinflammation and autoimmunity by disrupting NF-κB feedback control and immune homeostasis.

Hypoxia-induced mitoROS triggers M1 linear ubiquitin chains and activates NF-κB signaling

The paper shows hypoxia-induced mitochondrial ROS leads to M1 ubiquitin chains, activating NF-κB signaling and increasing target gene expression in response to mitochondrial stress.

JNK integrates immune and stress signals to balance apoptosis and proliferation in airway progenitors

This study identifies JNK as a key integrator of immune and stress signals in airway progenitors, balancing apoptosis and proliferation to maintain tissue homeostasis during inflammation.

NF-κB driven inflammation mediates loss of upper airway epithelial tolerance to Streptococcus pneumoniae during influenza co-infection

This study shows that influenza co-infection disrupts epithelial tolerance to Streptococcus pneumoniae via NF-κB driven inflammation, leading to bacterial invasion and highlighting TRAF6-NF-κB as a therapeutic target.

WDR81 represses IKK mediated expression of pro-survival genes to regulate apoptosis

This study identifies WDR81 as a regulator of apoptosis by repressing IKK-mediated pro-survival gene expression, revealing its role in controlling cell death during viral infection.

MK2/p38/p53 suppress basal IL-1β and non-canonical NF-κB signaling

The paper shows that MK2/p38/p53 suppress basal IL-1β and non-canonical NF-κB signaling by regulating p53 and RelB cleavage.

E(spl)m4 Directly Antagonizes Traf4 to Inhibit JNK Signaling in Drosophila

This study identifies E(spl)m4 as an inhibitor of Traf4 signaling in Drosophila, preventing JNK activation and cell delamination without affecting Adherens Junctions.

Constitutive NF-kB Activation is Amplified by VSV in Aggressive PC3 Prostate Cancer Cells that Resist Viral Oncolysis

This study shows that PC3 prostate cancer cells resist VSV oncolysis due to constitutive NF-kB activation, which is amplified by VSV infection through I{kappa}B--independent mechanisms.

Cooperativity among clustered κB sites within promoters and enhancers dictates transcriptional specificity of NF-κB RelA along with specific cofactors

Targeting DNA Polymerase Epsilon Leads to Tumor Clearance and Activation of an NF-κB mediated inflammatory response in Triple Negative Breast Cancer

This study shows that inhibiting DNA polymerase epsilon in TNBC triggers an NF-κB-driven inflammatory response and tumor clearance in mice.

Stem cell-specific NF-kB is required for stem cell survival and epithelial regeneration upon intestinal damage.

This study shows that stem cell-specific NF-kB is essential for intestinal epithelial regeneration after damage in Drosophila.

Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics

The paper shows that prolonged IKK activation from time-varying cytokine stimuli leads to nuclear NF-κB retention via chromatin remodeling, with simulations accurately predicting single-cell responses.

Activation of NF-κB signaling by optogenetic clustering of IKKα and β

The paper develops optogenetic tools to cluster eGFP-tagged proteins and uses them to activate NF-κB signaling by clustering IKKα and IKKβ.

Comparison of Activities of Transcription Factor NF-κB from Two Jellyfish Models

This study compares NF-κB activity in two jellyfish species, showing differences in transcriptional activation and subcellular localization.

Spatiotemporal dynamics of NF-κB/Dorsal inhibitor IκBα/Cactus in Drosophila blastoderm embryos

This study visualizes Cactus dynamics in Drosophila embryos using LlamaTag and optical techniques, revealing nuclear localization and biophysical parameters of the NF-κB pathway.

Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell proliferation

The paper develops a mathematical model to study how BCR and CD40 signals integrate to control B-cell proliferation and selection, revealing synergistic and antagonistic interactions.

Ubiquitin-specific peptidase 20 constrains endothelial cell activation and angiogenic sprouting through NF-κB inhibition

This study shows that USP20 inhibits NF-κB signaling in endothelial cells, reducing angiogenesis, and that phosphorylation of USP20 at Ser334 enhances NF-κB activity and promotes angiogenic sprouting.

Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal

This study shows that inhibiting PGK1 with CBR-470-2 reduces NF-κB signaling by increasing methylglyoxal, which inactivates NF-κB proteins.

Transcriptional Repression by RelA and Yin Yang1 is essential for survival of Colorectal Cancer Cells

This study shows that RelA and YY1 form a complex to repress the pro-apoptotic gene Puma, promoting colorectal cancer cell survival.

Contrasting roles for IKK regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

This study investigates the role of IKK-regulated inflammatory pathways in the development and survival of type 1 and adaptive γδ T cells, revealing distinct requirements compared to β T cells.

Oncogenic Ras-driven Dorsal/NF-κB signaling contributes to tumorigenesis in a Drosophila carcinoma model

This study shows that oncogenic RasV12 activates Dorsal/NF-κB signaling, promoting tumor growth and malignancy in Drosophila melanogaster tumors.

Bottom-up reconstruction of functional Death Domain Signalosomes reveals a requirement for polymer stability and avidity

The paper constructs a synthetic signalosome using Death Domains and shows that its function depends on polymer stability and avidity, demonstrating these properties are tunable and not restricted to specific motifs.

Macrophages maintain signaling fidelity in response to ligand mixtures

This paper shows macrophages maintain stimulus-response specificity through NFκB signaling even when exposed to multi-ligand mixtures, using mathematical modeling and live-cell experiments.

Ubiquitination-activated TAB-TAK1-IKK-NF-kB axis modulates gene expression for cell survival in the lysosomal damage response

The paper identifies the TAB-TAK1-IKK-NF-κB axis as a ubiquitin-regulated pathway activated by lysosomal damage, promoting cell survival through anti-apoptotic and intercellular signaling genes.

Poxvirus attack of anti-viral defense pathways unleashes an effector-triggered NF-κB response

The paper identifies a poxvirus effector that triggers an NF-κB response by disrupting anti-viral complexes, revealing a novel ETI pathway.

Selective disruption of Traf1/cIAP2 interaction attenuates inflammatory responses and limits sepsis and rheumatoid arthritis

This study identifies a TRAF1 mutation that disrupts its interaction with cIAP2, reducing inflammation and protecting against sepsis and rheumatoid arthritis.

Targeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha.

This study identifies non-canonical NF-κB signalling as a therapeutic target in CYLD cutaneous syndrome and shows that IKK inhibition reduces tumor viability in patient-derived models.