Nuclear Structure and Function

Palmitoylated importin α recruits PKCε to the plasma membrane to drive breast cancer cell motility

A multiscale chromatin collapse underlies vascular pathology in Hutchinson -Gilford progeria syndrome

This study identifies chromatin reorganization and histone mark changes in HGPS VSMCs, linking them to vascular pathology through disrupted enhancer-promoter interactions.

Building the meiotic bouquet: A nuclear polarity pathway in Arabidopsis

The paper identifies a nuclear polarity pathway in Arabidopsis meiosis by showing how telomeres interact with SUN1/2 domains on the nuclear envelope to form a bouquet structure.

Developmental conversion of the nucleolus into an RNA Polymerase II transcriptional platform in Drosophila spermatocytes

The paper shows that in Drosophila spermatocytes, nucleoli convert into NLBs that serve as platforms for RNA Polymerase II transcription of Y-linked fertility genes.

Super-resolved spatial organization of the nucleolar transcriptome

The paper uses super-resolution imaging and in situ sequencing to map RNA distribution within nucleolar subdomains, revealing distinct RNA populations and processing dynamics.

Vimentin molecular linkages with nesprin-3 enhance nuclear deformation by cell geometric constraints

This study shows vimentin enhances nuclear deformation in polarized cells by linking to nesprin-3 and transmitting forces through the nuclear envelope.

The role of the nuclear pore complex in the stability of disease-related short tandem DNA repeats

This study shows disease-related short tandem repeats relocate to nuclear pore complexes, with implications for genome stability and repeat dynamics.

Nuclear SUN2 coordinates endothelial cell-matrix interactions to regulate blood vessel homeostasis and barrier function

This study shows that SUN2 in the nucleus regulates endothelial cell-matrix interactions, affecting vascular homeostasis and barrier function through microtubule and matrix metalloprotease mechanisms.

Nucleolar Dynamics During Oogenesis

This study investigates nucleolar changes during zebrafish oogenesis and finds similar patterns in mouse oocytes, suggesting conserved nucleolar remodeling for translational adaptation.

Antagonistic contributions of A-type and B-type lamins to LBR localization and dynamics

This study shows that A-type and B-type lamins have opposing roles in LBR localization and dynamics, with lamin A displacing LBR from the nuclear envelope while lamin B1/B2 tether it.

Expression levels and dimer abundance of lamin A/C direct nuclear shape integrity in malignant cancer cells

This study links reduced lamin A/C expression and dimerisation to nuclear deformability in malignant cancer cells, showing greater sensitivity in MDA-MB-231 cells.

Prophase Chromosomes Relocalization to Nuclear Periphery in NPP-3/NUP205 Depletion Protects Genome Stability

This study shows that NPP-3/NUP205 depletion in C. elegans embryos causes chromosomal relocalization to the nuclear periphery, which protects genome stability by reducing DNA damage and micronuclei formation.

Nonspecific steric hindrance of protein particles by lamina-associated domains

The paper investigates how lamina-associated domains (LADs) act as size-selective steric barriers to limit protein access to the nuclear periphery, providing a biophysical mechanism for gene regulation.

Sequence and Structural Alignments Reveal Insights into ANKLE2 Evolution and Function

The paper uses sequence and structural alignments to study ANKLE2 evolution and function, revealing conserved domains and potential roles in DNA damage response.

CYCLON is a nucleolar protein that regulates pan-cancer cell fitness through ribosome biogenesis

This study identifies CYCLON as a nucleolar protein that regulates cancer cell fitness by controlling ribosome biogenesis and nucleolar structure across multiple tumor types.

Bound for the nucleus: defining the molecular principles of cargo selection by importin 9

This study identifies 79 cargos bound by IPO9, showing it recognizes proteins without cNLSs, and defines structural elements that mediate cargo selection and release.

Lamins and lineage-relevant transcription factors coordinate gene expression in lineage development

The paper shows that lamins A and B1 maintain LADs and gene expression in yolk sac endoderm by interacting with transcription factors.

Importins recognize the winged-helix fold of ETS transcription factors to mediate nuclear import

The paper identifies the ETS domain as a structure-encoded NLS recognized by importins, revealing how importins mediate nuclear import of ETS transcription factors.

Loss of nuclear-cytoplasmic compartmentalization is a hallmark of aging in podocytes

This study shows that aging podocytes lose nuclear-cytoplasmic compartmentalization, leading to metabolic and transcriptional dysregulation.

The Nuclear Pore Complex Facilitates Centriole-Nuclear Attachment in Spermatids

The paper identifies Nup133 and Nup107 as regulators of HTCA development and shows that NPCs recruit dynein to the nuclear envelope to facilitate centriole-nuclear attachment during spermiogenesis.

Increased Telomere Mobility in Progeria is Restored by Isoprenylcysteine Carboxyl Methyltransferase Inhibition

This study quantifies telomere dynamics in HGPS patient fibroblasts and shows that C75 fully restores chromatin dynamics while Lonafarnib only partially rescues them.

Nuclear polysaccharides maintain H3K9me3-heterochromatin and genomic stability

The paper shows that nuclear N-glycans modify INM proteins, regulate H3K9me3, and maintain genomic stability by interacting with SETDB1.

The inner nuclear membrane protein SUN1 regulates cullin-3 neddylation to maintain insulin signaling

This study shows that the SUN1 H118Y variant impairs CUL3 neddylation, leading to insulin resistance, and that inhibiting neddylation can restore insulin signaling.

The dynamics of nucleolus-centromeres interaction in living cells

This study examines the dynamic interactions between nucleoli and centromeres in living cells, showing that centromeres move and associate with nucleoli during interphase, with these interactions dependent on rDNA transcription and nucleolar integrity.

Dysregulated nuclear Lamin B1 in DYT1 dystonia thickens the nuclear lamina and disrupts 14-3-3 proteins

This study investigates how dysregulated Lamin B1 in DYT1 dystonia affects nuclear structure and disrupts 14-3-3 proteins, linking nuclear deformation to neuronal dysfunction.

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen

The paper identifies hnRNPK as a key regulator of LAD positioning and reveals two distinct LAD classes based on epigenetic marks.

Perinuclear anchoring of telomeres enables plant infection by Ustilago maydis

This study shows that perinuclear telomere anchoring via Lem2 is essential for Ustilago maydis to infect plants, as its deletion disrupts nuclear migration and leads to infection failure.

RNA polymerase loss by nuclear rupture drives LMNA cardiomyopathy

This study shows that nuclear rupture in LMNA-DCM leads to transcriptional deficiency and identifies resealing as a protective mechanism that is ultimately insufficient.

Nuclear pore complex distribution on the nuclear envelope: insights into curvature, chromatin, and actin contributions

The paper uses super-resolution microscopy to analyze NPC distribution on the nuclear envelope, finding repulsion lengths, actin, heterochromatin, and curvature correlations.

LBR nucleoplasmic domains regulate X-chromosome solubility and nuclear organization

This study shows that LBR nucleoplasmic domains regulate X-chromosome solubility and nuclear organization during neural differentiation in mouse cells.