T-cell and B-cell Immunology

Single-Cell and Spatial Analysis Reveals Retention of FCRL4⁺ Memory B Cells in Pediatric Tonsillar Hypertrophy

The paper identifies FCRL4+ memory B cells retained in hypertrophic pediatric tonsils through single-cell and spatial analysis, showing their interaction with Tr1 cells to sustain follicular hypertrophy.

Lymphatic networks enable diversification of B cell responses to vaccines

This study shows that lymphatic networks create spatially distinct environments in draining lymph nodes that influence B cell differentiation, affinity selection, and antibody isotype, which can be manipulated through vaccine design.

Discovery of rare antigen-specific TCRs via replicate profiling

The paper develops a high-throughput TCR discovery assay to identify antigen-specific T cells, finding over 90 SARS-CoV-2-specific TCR clonotypes in one donor and nearly 1,000 in five donors.

Distinct transcriptional states of draining lymph node T cells following influenza vaccination in individuals with underrepresented ancestries

This study identifies distinct transcriptional states of T cells in draining lymph nodes after influenza vaccination in individuals with African or Asian ancestry using scRNA-seq.

Cognate T-cell labeling by conventional and unconventional antigen-presenting cells in vivo using a modular SrtA-based toolkit

This paper introduces a modular SrtA-based toolkit to track T-cell interactions with different antigen-presenting cells in vivo, showing that ILC3s and conventional dendritic cells activate CD4+ T cells similarly.

Sympathetic neurons control adaptive immunity in response to Streptococcus pneumoniae infection by regulating T cell and B cell effector function

This study shows that sympathetic neurons regulate T cell and B cell responses to Streptococcus pneumoniae infection, enhancing IgG production and bacterial clearance.

Age-associated Autoimmunity Driven by T cell Immunosenescence

This study identifies age-associated senescent CD4+ T cells as drivers of autoimmunity in CIDP, showing that senolytic and senomorphic therapies can mitigate disease.

CD55-CD319-CX3CR1 flow cytometry gating strategy recapitulates scRNA-seq-defined memory CD8 T cell subpopulations

This paper develops a flow cytometry gating strategy using CD55, CD319, and CX3CR1 to identify transcriptionally defined CD8 T cell subpopulations, improving resolution over conventional methods.

A cell-intrinsic steroidogenic checkpoint constrains female Th2 effector output independently of gonadal hormones

DGKα and ζ Deficiency Causes Regulatory T-Cell Dysregulation, Destabilization, and Conversion to Pathogenic T-Follicular Helper Cells to Trigger IgG1-Predominant Autoimmunity

This study shows that DGKα and ζ deficiency in Tregs leads to their dysfunction, conversion to pathogenic Tfh cells, and triggers IgG1-predominant autoimmunity.

Durability and diversity of human upper airway T cell memory

This study longitudinally tracks antigen-specific T cells in human upper airway tissues and blood, finding sustained memory T cell populations over 18 months.

An anti-Galectin-3 intrabody improves primary and memory response of antigen-specific CD8+ T cells during viral infection

This study shows that an anti-Galectin-3 intrabody enhances CD8+ T cell activation, proliferation, and memory formation during viral infection.

Apoptotic Quality Control of Cellular Competence Limits Cryptic Germinal Center B Cell States

This study shows that mitochondrial apoptosis limits non-proliferating and defective B cell states in germinal centers without affecting affinity maturation.

IL-27 induces a cytotoxic state in CD4+ T cells distinct from the Th1 lineage

This study identifies IL-27 as an inducer of a distinct CD4+ cytotoxic T cell program that differs from Th1 lineage.

BRWD1 establishes epigenetic states for germinal center initiation, maintenance, and function

This study shows BRWD1 is essential for maintaining epigenetic states in germinal center B cells, affecting their function and subset identity.

Distinct activation programs in naive and memory CD8 T cells govern stemness and effector persistence of their progeny

The paper shows that prior antigen exposure redirects CD8 T-cell activation programs, shaping progeny fate and persistence through distinct stemness and effector programs in naive and memory cells.

Investigating the Role of Different Co-receptors on T-cell Activation Through IFN-γ Secretion Using Spatially Controlled Cell Monitoring Platform

This paper adapts the CellStudio platform to study T-cell activation by co-receptor engagement, showing that combined anti-CD3 and anti-CD4 stimulation leads to stronger IFN-γ secretion and altered contact morphology in Jurkat T-cells.

Intestinal uptake regulates T cell responses to dietary antigens

Intestinal uptake, set by protein solubility and goblet versus M cell sampling, limits how strongly different zein preparations induce antigen-specific intestinal T cells in mice.

immgenT CD4: A Reference Landscape of Mouse CD4+ T Cells

The paper profiles mouse CD4+ T cells across >700 samples to identify 20 molecular states, revealing diverse effector functions and unexpected similarities between Tfh and chronically stimulated states.

The early-life determinant LIN28B constrains immunoglobulin light chain secondary rearrangements independent of BCR specificity

This study shows LIN28B restricts IgL secondary rearrangements in B cells independently of BCR specificity, shaping early-life immunoglobulin repertoire bias.

The Notch signaling pathway is a master regulator of CD8+ T cell exhaustion and differentiation during chronic infection

This study shows that Notch signaling regulates CD8+ T cell exhaustion and differentiation during chronic infection by promoting the transition from progenitor to effector-like cells and preventing terminal exhaustion.

IL-17 producing tissue-resident memory T-cells expanded during Staphylococcus aureus nasal colonisation provide heterologous immune protection.

This study shows that S. aureus nasal colonization expands IL-17-producing TRM cells that provide non-specific protection against unrelated infections.

Selective Immune Silencing by Targeted TGF-β Mimics

This paper develops TGF-β agonists targeting specific T and B cells to selectively suppress pathogenic immune responses in autoimmune and inflammatory diseases.

A Reference Landscape of Regulatory T Cell States in Mice

The paper defines a unified framework for Treg heterogeneity using a joint RNA-protein model, identifying eight conserved clusters across tissues and conditions.

Longitudinal analysis of the B-cell receptor repertoire across 30 years of ageing

This study examines changes in the B-cell receptor immunoglobulin heavy chain gene repertoire over 30 years of aging, finding reduced diversity and increased clonality after age 60.

A CD40-Targeted IL-21 Fusokine Enables Rapid Generation of Human IL-10⁺Granzyme B⁺ Regulatory B Cells

This paper demonstrates that a CD40-targeted IL-21 fusion protein and TLR9 activation can induce a stable regulatory B cell phenotype in human B cells with high efficiency.

A comprehensive reference of mouse CD8αβ T cell differentiation states

The paper establishes immgenT-CD8 as a comprehensive reference for mouse CD8αβ T cell differentiation states across diverse immunological contexts.

Unsupervised identification of low-frequency antigen-specific TCRs using distance-based anomaly scoring

This paper introduces an unsupervised method to detect low-frequency antigen-specific TCRs using distance-based anomaly scoring, achieving higher accuracy than existing methods in three immunological contexts.

Antibody-dependent priming of spontaneous germinal centers by autoreactive B cells

This study shows autoreactive B cells can initiate spontaneous germinal centers and autoimmunity through antibody-dependent mechanisms, independent of T cell interactions or antigen presentation.

Systematic Evaluation of Nasal Immune Cell Sampling and Antigen-specific T cell Detection using Cryopreserved Nasal Swabs

This study evaluates nasal immune cell sampling methods and antigen-specific T cell detection using cryopreserved nasal swabs, finding that flocked swabs yield more cells and cryopreservation preserves functional T cells.