T-cell and B-cell Immunology

Site-dependent Treg cell transcriptional reprograming in a metastatic colorectal cancer model holds prognostic significance

The paper identifies location-specific transcriptional differences in tumor-infiltrating Treg cells across CRC metastases and links these to poor patient prognosis.

Combination adjuvants drive long lived plastic Th17 cells that convert to multi-functional Th1 cells and protect mice against fungal infection

The paper shows that combination adjuvants drive Th17 cells that convert to multi-functional Th1 cells, enhancing antifungal immunity in mice.

BenchRep-T: A Systematic Evaluation of T-Cell Repertoire-Based Disease Diagnostics

BenchRep-T evaluates nine T-cell repertoire methods across four tasks, finding simple baselines competitive with complex models and no single method dominates all tasks.

A feedback control for restraining autoimmune γδ T cells: reprogramming into ILC1s

This paper identifies a feedback mechanism where Vγ1.1Vδ6.3 T cells are reprogrammed into ILC1-like cells to restrain autoimmune pathology.

BCR ligation selectively inhibits IgE class switch recombination

This study shows that BCR ligation selectively inhibits IgE class switch recombination in mouse and human B cells, with synergistic effects from IL-21 and TGFβ1.

Adenosine deaminase co-immunization reverses age-associated immunosenescence by restoring germinal center T follicular helper cell function

This study shows that co-immunizing with adenosine deaminase and a DNA vaccine improves T follicular helper cell function and antibody quality in aged mice, enhancing protection against C. difficile infection.

Distinct transcriptional programs define human IgG4+ memory B cells

This study identifies distinct transcriptional programs in human IgG4+ memory B cells, revealing unique features and potential therapeutic targets.

A 50-marker mass cytometry panel to expand analysis of the functional breadth of human immune cells

This paper introduces a 50-marker mass cytometry panel to comprehensively profile functional diversity in human immune cells, detecting cytokines and chemokines beyond traditional panels.

Evaluating the effects of CD8/CD4 on T cell function in terms of TCR-pMHC-coreceptor catch and slip bonds

This study evaluates how CD8/CD4 coreceptors affect T cell function by analyzing TCR-pMHC catch and slip bonds, finding that coreceptors enhance bond metrics and TCR sensitivity and specificity.

CD96-mediated internalisation of ligand CD155 as a novel mechanism for immune regulation

This study identifies CD96 as the dominant mediator of CD155 internalisation in human T cells through receptor cycling and variant-specific differences.

Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias

This study identifies antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination using single-cell RNA and TCR sequencing, revealing phenotypic differences between stimulated and unstimulated states.

Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCRβ selection

The paper shows preselection CD4+CD8+ thymocytes undergo gene expression changes linked to reduced TCR responsiveness and impaired CD4 fate gene upregulation, connecting these changes to T cell lineage commitment.

Aging restricts maturation of CXCL13+ T follicular helper cells in human immunity

This study identifies age-related defects in CXCL13+ T follicular helper cells in human tonsil organoids, linking them to reduced antibody responses.

Altered PI3K-PTEN balance promotes preferential killing of human IgE+ plasma cells by BCR crosslinking

The paper shows that human IgE+ plasma cells are selectively killed by BCR crosslinking due to a JNK/PTEN/BIM signaling axis, distinct from mouse mechanisms, and highlights therapeutic implications for anti-IgE antibodies.

Clonal dynamics of germinal center refueling by secondary immunization

This study investigates how booster immunizations affect germinal center (GC) clonality in mice, finding that refueling leads to clonal expansion rather than memory recruitment.

UcTCRp: a TCRβ-based framework for quantitative MAIT- and iNKT-associated repertoire-state profiling

UcTCRp profiles MAIT- and iNKT-associated immune states using TCRβ sequences without requiring single-cell data or antigen-specific markers.

Comprehensive Profiling of Age- and Immune Cell- Specific Signaling Activation Using Multiplex Phosphoflow

The paper develops a multiplex phosphoflow assay to profile age- and immune cell-specific signaling activation in 18 subpopulations, revealing distinct patterns in healthy individuals aged 1-69 years.

ACLY integrates metabolism and chromatin accessibility to enable B Cell activation and humoral immunity

This study shows ACLY links metabolism to chromatin accessibility in B cells, essential for activation and humoral immunity.

The in vivo inhibitory function of the MHC-I alpha3 domain/CD8alpha interaction

This study identifies the MHC-I alpha3 domain-CD8 interaction as an inhibitory pathway that restrains CD8+ T-cell activation and maintains tolerance in vivo.

The NKCC1 inhibitor bumetanide has no discernible effect on plasma cell survival, persistence or antibody secretion

This study shows that inhibiting NKCC1 with bumetanide does not affect plasma cell survival, persistence, or antibody secretion in vitro and in vivo.

Multi-omic profiling of human thymic B cells reveals intrathymic Ig-class switching and differentiation into multiple memory B cell subsets

The paper identifies and characterizes distinct B cell subsets in the human thymus, revealing their development, differentiation, and class switching capabilities.

A regulatory TRIF/IL-1R1 axis controls T-dependent IgA production in the intestines

This study identifies TRIF and IL-1R1 as regulators of intestinal IgA production, showing their roles in controlling IgA class-switching and germinal center B cell differentiation.

Fibroblast TGF-β3 promotes tissue-residency and survival of CD8 T cells in barrier tissues and tumors

This study identifies fibroblast-derived TGF-β3 as a critical factor sustaining CD8+ TRM in barrier tissues and tumors, showing its role in survival and function.

AbSolution: interactive exploration of sequence-derived features in AIRR-seq repertoires

AbSolution enables integrated analysis of sequence-derived features in immune repertoires across datasets and conditions.

Hierarchical Immune Suppressive Functions of Regulatory T Cells Built on Mechanical Force

This study identifies a hierarchical mechanical force-based model of Treg suppression, showing that stable adhesion is required for localized cytokine delivery to dendritic cells.

Age-dependent PD-1 induction restricts IL-2-driven effector T cell responses during La Crosse virus infection in mice

This study shows that age-dependent PD-1 induction limits IL-2-driven effector T cell responses during La Crosse virus infection in mice, leading to impaired viral control.

Reproducible detection of antigen-specific T cells and Tregs via standardized and automated activation-induced marker assay workflows

This study improves the reproducibility of antigen-specific T cell detection using standardized AIM assay workflows and automated analysis tools.

Nuclear receptor LRH-1 regulates early T cell development in mice

This study shows LRH-1 is essential for early T cell development and functional CD4 T cell responses in mice.

Early-life mucosal T cells direct intestinal stem cell fate via a coordinated developmental program

This study shows that early-life mucosal T cells promote intestinal stem cell renewal and secretory differentiation through direct interactions and signaling, with impaired function in NEC and adult T cells.

Low-self-reactive, circulation-biased blood regulatory T cells sense danger-associated nucleotides to restrain atherosclerosis

The paper identifies circulation-biased blood regulatory T cells that respond to danger-associated nucleotides to suppress atherosclerosis.