T-cell and B-cell Immunology

Tissue-specific adaptation of human T cells is preserved during tissue inflammation

The paper examines tissue-specific T cell adaptations in healthy and inflamed human mucosal tissues, finding that these adaptations are largely maintained during inflammation.

Competing gene regulatory networks drive naive and memory B cell differentiation

This study identifies distinct gene regulatory networks driving naive and memory B cell differentiation, showing IRF4's role in both GC and plasma cell development independently of PRDM1.

Immune-induced TCR-like antibodies regulate specific T cell response

This study identifies immune-induced TCR-like antibodies (iTabs) that inhibit T cell receptor recognition of antigen-presenting MHC class II molecules, offering a strategy to suppress autoimmune disease.

Enhanced human antigen-specific B cell responses using in vitro 3D tonsil cultures containing stromal cells

This study shows that 3D tonsil cultures with stromal cells enhance antigen-specific B cell responses compared to 2D cultures and improve follicle-like structure formation.

KLRG1 identifies circulating cytotoxic CD4 T cells with selective anti-tumor function in human cancer

This study identifies KLRG1 as a marker for cytotoxic CD4 T cells in cancer patients and shows their anti-tumor function and regulation by IL-6.

Canonical WNT Ligands Produced by Regulatory T Cells Restrain Effector CD4+ T Cell Responses

This study identifies Tregs as a source of canonical WNT ligands that suppress effector CD4+ T cell responses through WNT signaling.

Deciphering antigen-driven T cell responses through vectorized TCRdist sequence neighborhood quantification

The paper introduces a computational framework to efficiently identify significantly neighbor enriched TCR sequences, demonstrating its utility in analyzing memory T cells and T cell responses to vaccination and viral infections.

Epigenetic signature at FOXP3 distal enhancer affects regulatory T cell development in Kabuki syndrome

This study identifies an epigenetic signature at the FOXP3 distal enhancer in Kabuki syndrome patients that impairs Treg development, linking KMT2D loss to immune dysregulation.

Clinical development of gene edited tacrolimus-resistant Treg (FKBP12KO-Treg) to enable simultaneous immunosuppression and support of immune regulation

This paper develops gene-edited tacrolimus-resistant Treg cells (FKBP12KO-Treg) for clinical use in transplant recipients, showing they maintain immunoregulatory function while resisting tacrolimus.

scRNA-seq revealed the rules for CDR3 length pairing in TCR beta and alpha chains and BCR heavy and light chains in human and mice

This study uses scRNA-seq to analyze CDR3 length pairing rules in TCR and BCR chains across human and mouse cells, revealing species-specific differences and increased plasticity in humans.

Postnatal Maturation of Dendritic Epidermal T Cells and Langerhans Cells Follows Distinct Differentiation Trajectories Independent of Microbiota

This study maps the postnatal differentiation trajectories of dendritic epidermal T cells and Langerhans cells in mice, showing they develop independently of each other and microbial colonization.

T cell intrinsic 4-1BB signals induce Prdm16 to increase effector and memory T cell numbers during respiratory influenza infection

This study shows that 4-1BB signaling in T cells during influenza infection induces Prdm16, enhancing effector and memory CD8 T cell numbers through mitochondrial and metabolic pathways.

The MLL1-MENIN complex preserves CD8 T cell memory through a TOX-BTLA-TCF1 axis

This study identifies the MLL1-MENIN complex as a regulator of CD8 T cell memory through the TOX-BTLA-TCF1 axis, independent of its methyltransferase activity.

Heterogeneous signaling pathways are critical for the persistence of memory T cells in spleen and bone marrow

This study identifies tissue-specific signaling pathways critical for memory T cell persistence in spleen and bone marrow.

A Glycolysis-Fatty Acid Metabolic Axis Shapes Human Tfh Cell Function

This study shows that early glycolysis inhibition enhances Tfh cell differentiation but impairs their function, revealing a glycolysis-fatty acid metabolic axis that controls Tfh function.

Fibroblast-IL-7 feedback drives PDPN+ monocytes to restrain CD4+ T cell responses

The paper identifies a fibroblast-IL-7 feedback loop that promotes immunosuppressive monocyte-derived cells, which restrain CD4+ T cell responses during infection.

T-bet Expressing B cells are Key Determinants of Protective Immunity Against Norovirus Infection

This study identifies T-bet expressing B cells as critical for mucosal immunity and protection against norovirus infection through IgG and IgA responses.

Stem-like PD-1+TCF-1+ CD8+ T cells result from helpless priming and rely on CD4+ T-cell help to complete their cytotoxic effector differentiation

This study shows that PD-1+TCF-1+ stem-like CD8+ T cells require CD4+ T-cell help to differentiate into effector cytotoxic T cells, but tumors fail to provide this help despite expressing helper epitopes.

Multi-parameter spectral flow cytometry panel for immune phenotyping of murine B and T cell responses

The paper develops a 31-parameter spectral flow cytometry panel to analyze immune responses in mouse B and T cells across multiple tissues.

Antibody Mediated Diversification of Primary and Secondary Humoral Immune Responses

This study shows that secreted antibodies significantly diversify primary and secondary humoral immune responses in mice, even at low antibody levels, with implications for vaccine design.

FNIP1 Modulates B Cell Receptor Signaling Strength by Coordinating Metabolism During Development.

This study identifies Fnip1 as a regulator of B cell development by modulating BCR signaling and metabolic pathways, leading to impaired differentiation and accumulation of specific B cell subsets.

Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function

This study shows that loss of FLII impairs CD8+ and regulatory T cell function by affecting trafficking and immune regulation.

Quantitative extrapolation from single-tags (QuEST) immunofluorescence microscopy to derive TCR signalosome stoichiometries in human primary T cells

The paper introduces QuEST immunofluorescence microscopy to quantify TCR signalosome stoichiometries in human T cells, revealing a 1:1 ZAP-70:TCR ratio and CD28 recruitment independent of CD80/CD86.

Barrier Immune Memory is Promoted by Intestinal Epithelial Cell Presentation of Injected Bacterial Antigens

The paper shows that CD4 T cell memory is enhanced when antigens are presented by intestinal epithelial cells rather than bacterial proteins.

Periweaning diet-induced activation of an IFNγ-mediated regulatory circuit promotes the homeostasis of cytotoxic CD8+ T Cells

The paper shows that periweaning diet activates an IFNγ-mediated circuit in cDC1 that promotes effector memory CD8 T cell homeostasis through immunogenic maturation.

Fc receptor dependent and independent mechanisms of antibody-mediatedenhancement of immune responses

This study identifies Fc gamma receptor-dependent and independent mechanisms by which pre-existing antibodies enhance germinal center and plasmablast responses and alter the affinity threshold for B cell recruitment.

Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for functional differentiation of Treg cells

The paper identifies cooperative roles of Foxp3 and BATF in directing cis-regulatory programs and gene expression for Treg cell differentiation.

TACI Regulates Marginal Zone B Cell Development

This study shows TACI regulates MZ B cell development through the PI3K-AKT pathway and FOXO1 inhibition, not B cell survival.

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility

This study shows that mitochondrial ATP production, induced by D-α-hydroxybutyrate, promotes T cell differentiation and function by regulating chromatin accessibility and gene expression.

Coordinated IL-2 and TGF-β Signaling Activates Stable Regulatory T Cells and Promotes Immune Tolerance

This study shows coordinated IL-2 and TGF-β3 signaling expands and activates regulatory T cells, reduces autoimmune responses, and promotes immune tolerance.