T-cell and B-cell Immunology

Response metrics of T-cell activation models

The paper develops a general method to derive expressions for Emax and EC50 in T-cell activation models and applies it to models lacking these expressions.

Gene regulatory network determinants of rapid recall in human memory CD4+ T cells

This study identifies gene regulatory networks in human memory CD4+ T cells that drive rapid recall, linking specific transcription factors to immune-mediated disease risk.

immunoPETE: A DNA-based integrated B-cell and T-cell receptor profiling platform

The paper introduces immunoPETE, a DNA-based platform for profiling B and T cell receptors, and demonstrates its performance in immune repertoire analysis and clinical applications.

Epithelial MHC II antigen presentation dynamically informs intestinal homeostasis and injury

This study shows that epithelial MHC II antigen presentation encodes tissue state and injury signals, maintaining homeostasis and promoting tolerance, while shifting toward damage-associated antigens during inflammation.

Transient immune landscape remodelling shapes CD8 T-cell priming during infection

The paper shows that transient immune architecture changes during infection protect low-affinity CD8 T-cell priming from Treg inhibition, ensuring broad T-cell responses.

MAIT cell responses to S. aureus and sensitivity to HlgAB are modulated by activation and tissue-dependent virulence effects

This study examines how MAIT cells respond to S. aureus and how their sensitivity to the toxin HlgAB varies by tissue location and activation state.

Addition of DMSO to T cell cultures skews differentiation towards a memory phenotype.

The paper shows that low DMSO concentrations skew T cell differentiation towards a memory phenotype during in vitro expansion.

IL-6 is a Key Factor in the Formation of Gut Tissue Resident Memory T Cells from Naïve T cells

This study identifies IL-6 as a key factor in the differentiation of naive CD4+ T cells into gut tissue resident memory T cells (TRMs) through a combination of MAdCAM-1, TGF-β, and RA signaling.

Tumors accumulate expanded GATA3-dependent tissue Tregs

The paper shows that tumors drive the accumulation of GATA3-dependent effector tissue Tregs through TCR-dependent oligoclonal expansion, promoting tumor growth.

Antibody maturation in germinal centers selects mutants based on BCR-antigen bond mechanical resistance

The paper investigates antibody maturation in germinal centers, finding that mechanical resistance of BCR-antigen bonds, not affinity, drives selection during maturation.

Unraveling new characteristics of γδT cells using scRNA-seq in TCR KO chicken

This study uses scRNA-seq to analyze γδT cells in TCR KO chickens, identifying novel gene markers and functional characteristics of β and γδ T cell subsets.

Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen

This study uses intravital microscopy to track autoreactive germinal centers in the spleen of live mice over weeks, revealing their dynamic expansion and contraction.

Single cell analysis of neonatal naïve CD8α+ T cells reveals novel subsets bridging the innate-adaptive spectrum

The paper identifies novel neonatal CD8β+ T cell subsets (FITs) with innate-like features, distinct from conventional and unconventional T cells, using cord blood samples.

The Src-family kinase Lyn plays a critical role in establishing and maintaining B cell anergy by suppressing PI3K-dependent signaling

This study shows Lyn is essential for B cell anergy by suppressing PI3K signaling in autoreactive B cells, highlighting its role in preventing autoimmunity.

HIF-1α+ CD4 T cells coordinate a tissue resident immune cell network in the lung

This study identifies HIF-1α+ CD4 T cells as key coordinators of a tissue-resident immune network in the lung during infection and cancer.

Identification and characterization of dietary antigens in oral tolerance

The paper identifies seed storage protein epitopes as targets of intestinal regulatory T cells that modulate immune responses to dietary antigens.

IL-2- and IL-4-dependent signaling play separate and sequential roles in the differentiation of GATA3-hi TH2 cells in vivo

This study shows IL-2 is needed for GATA3 upregulation in TH2 cells, while IL-4 promotes their proliferation and effector function in vivo.

Tissue-specific clonal selection and differentiation of CD4+ T cells during infection

This study uses TRACK mice to show tissue-specific clonal selection and differentiation of CD4+ T cells during influenza infection, revealing organ-specific transcriptional programs and memory formation patterns.

Cbfb2 gene dosage programs the differential lymphoid lineage developmental potential of fetal and adult hematopoietic progenitors

This study shows that Cbfb2 gene dosage regulates the developmental potential of hematopoietic progenitors, enabling fetal-like lymphoid lineage generation in adults.

Functional Type I and Type II interferon crosstalk restricts progenitor exhausted CD8 T cells through spatial exclusion and checkpoint enforcement

This study identifies a spatially encoded interferon circuit that restricts progenitor exhausted CD8 T cells during chronic infection by enforcing niche sequestration and checkpoint control.

Antibody responses against bacterial glycans affinity mature and diversify in germinal centers.

The paper shows that glycan-specific B cells undergo class-switching and diversification in germinal centers with age and infection, influencing vaccine design.

Characterization of a heterogenous activated B cell compartment arising early after antigen exposure preceding long-lived memory B cell formation

The paper characterizes early antigen-specific B cell responses after vaccination, identifying distinct clusters with different contraction dynamics and potential roles in memory B cell formation.

Human Anti-Glycan Reactivity is Driven by the Selection of B cells Utilizing Private Antibody Gene Rearrangements that are Affinity Maturated in Germinal Centers

The paper analyzes the human anti-GlcNAc B cell repertoire using BCR cloning and single-cell transcriptomics, finding germinal center-driven affinity maturation and diverse glycan specificity.

Adult mice with neonatal-like T cell subsets exhibit increased susceptibility to Bordetella pertussis and influenza infection

This study shows that adult mice with neonatal-like T cell subsets are more susceptible to Bordetella pertussis but not influenza, highlighting the role of thymic development in immune responses.

Transcriptome-Proteome analysis of human naive and memory B cell subsets reveal isotype and subclass-specific phenotypes

The paper analyzes transcriptome and proteome data of human naive and memory B cells to identify isotype-specific phenotypes, finding distinct expression profiles in IgG4-switched B cells.

Dnmt3a-mediated de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells

This paper shows that Dnmt3a-mediated DNA methylation is essential for maintaining lineage commitment and function of memory Th1 and Tfh cells, and that early inhibition of this process can enhance Tfh cell differentiation.

Integrated Modeling of BCR/TCR Repertoire Diversity Reveals the Mechanistic Basis of Immune Imprinting and Chronic Infection Control

This paper develops a multi-scale mathematical model to integrate BCR/TCR repertoire diversity with immune kinetics, revealing mechanisms of immune imprinting and chronic infection control.

Type 1 and type 2 dendritic cell subsets cooperate to maintain intestinal immune tolerance via integrin αvβ8-mediated TGF-β activation

This study identifies cDC1 and cDC2 as essential for TGF-β activation and pTreg induction in the gut, maintaining immune tolerance.

Dose-dependent activation of Syk and SHIP1 by LynA and LynB at steady state creates a threshold for macrophage signaling in the absence of receptor engagement

The paper shows that LynA and LynB expression levels determine steady-state phosphorylation of Syk and SHIP1, limiting macrophage signaling without microbial stimulation.

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes

The paper shows that late-entering B cells in germinal centers mainly become memory B cells that recognize less common antigen parts.