Muscle Physiology and Disorders

Disrupted FAP-satellite cell communication contribute to maladaptive muscle remodeling in older women

This study identifies altered FAP-satellite cell communication and impaired myogenic function in older women during recovery from disuse atrophy, contributing to poor muscle remodeling.

Exercise preconditioning confers skeletal muscle myometaplasticity

The paper shows that exercise preconditioning enhances skeletal muscle hypertrophy through epigenetic and metabolic changes, specifically involving Smox and Wnt signaling.

Multiomics Characterization Identifies S1P-secreting USSHigh Skeletal Muscle Stem Cells as Essential Drivers of Niche Remodeling and Muscle Regeneration

The paper identifies a senescent-like muscle stem cell subpopulation that drives muscle regeneration through secretory activity and cell communication.

Transcriptome analysis reveals CCND2 promotes myogenic differentiation of pig skeletal muscle

The paper identifies differentially expressed genes and gene modules in pig skeletal muscle and shows CCND2 promotes myogenic differentiation.

Gut microbiota-dependent phenylpropanoic acid derivatives reduced in cancer cachexia protect against myotube atrophy

The paper identifies gut microbiota-derived metabolites that protect against muscle atrophy in cancer cachexia by restoring amino acid homeostasis through the serine biosynthesis pathway.

Regeneration-associated utrophin expression in skeletal muscle: implications for utrophin-targeted therapies

This study shows that utrophin expression in skeletal muscle is closely tied to regeneration phases and cannot be used alone to assess therapeutic effects, suggesting the need for combined markers.

Tceal7 is a BRG1-regulated target of calcineurin signaling that promotes myoblast differentiation

This study identifies TCEAL7 as a BRG1-regulated target of calcineurin signaling that promotes myoblast differentiation and reveals its role in myogenic gene regulation.

Emerin loss of function inhibits MyoD-driven differentiation of human iPSCs into skeletal myotubes

This study shows that emerin loss impairs MyoD-driven differentiation of human iPSCs into skeletal myotubes by affecting PRC2-mediated gene regulation.

Sarcomere length, fascicle length, and serial sarcomere number are preserved in paretic hindlimb muscles following chronic stroke in rats despite persistent motor impairment

This study finds that chronic stroke in rats does not significantly alter sarcomere length or dispersion in paretic hindlimb muscles despite persistent motor impairment.

Evidence of complete myofibril remodeling after severe damage in adult Drosophila.

This study shows adult Drosophila muscles can fully remodel damaged myofibrils, with filamin mechanosignaling playing a critical role in repair, and identifies a progressive deterioration during aging.

Arginine methyltransferase signalling is hyperactive in conditions of neuromuscular junction instability and muscle atrophy

This study shows that CARM1 activity increases in neuromuscular junction instability and muscle atrophy in mice and humans, correlating with NMJ dysfunction and muscle health decline.

REDD1 Regulates MERCS, Protein Synthesis and NMJ Stability in Fast Myofibers During Dexamethasone-Induced Muscle Wasting

Aging concomitantly reduces skeletal muscle proteome plasticity and hypertrophic responses to resistance training

This study shows aging reduces proteome plasticity and hypertrophic responses to resistance training in skeletal muscle, but RT partially reverses some aging-related changes.

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

This study shows that glucocorticoid receptor signaling in myeloid cells affects inflammation resolution and muscle repair by regulating macrophage dynamics and satellite cell function.

Reduced Myonuclear Number Is Accompanied by More Regular Longitudinal Nuclear Positioning During Muscle Growth

The paper examines how reduced myonuclear number during muscle growth affects nuclear positioning, finding more regular longitudinal distribution reduces cytoplasmic regions distant from nuclei.

Furan fatty acid supplementation protects against muscle atrophy during cancer cachexia

This study shows that FuFA-F2 supplementation prevents muscle atrophy and preserves muscle function in a cancer cachexia model without affecting tumor growth.

ULK1 and ULK2 Restrain Skeletal Myofiber Growth by Balancing Protein Synthesis and Degradation

This study shows that ULK1 and ULK2 regulate skeletal muscle growth by balancing protein synthesis and degradation, with lifelong deficiency causing hypertrophy but reduced muscle quality and function, while short-term deficiency allows hypertrophy without impairment.

Positive allosteric modulator of SERCA pump NDC-1171 attenuates cardiac functional decline in mouse model of Duchenne muscular dystrophy

NDC-1171, a SERCA pump modulator, preserves cardiac function in DMD mice but does not improve skeletal muscle function.

Functional primary human 3D skeletal muscle models enable exercise and metabolic research

The paper develops primary human skeletal muscle organoids that mimic metabolic and exercise responses, showing alignment with in vivo responses and detecting drug effects.

Tumor-derived SAA1-TLR4 signaling drives tumor-to-muscle communication in pancreatic cancer cachexia

This study identifies SAA1-TLR4 signaling as a tumor-derived pathway driving muscle wasting in pancreatic cancer, showing that targeting this pathway can preserve muscle mass and improve survival without affecting tumor growth.

Androgen receptor imprints satellite cells stemness and preserves their reservoir for lifelong regeneration and optimal repair

This study shows androgen receptor signaling maintains skeletal muscle stem cell quiescence and regenerative capacity, and its loss leads to premature activation and stem cell depletion.

Metabolic Heterogeneity of Muscle Stem Cells is Controlled by the Myofiber Niche

This study reveals metabolic heterogeneity in muscle stem cells and shows that their metabolism is regulated by adjacent myofibers in the niche.

Biomechanical regulation of Ca2+ dynamics during muscle stem cell activation

This study examines Ca2+ dynamics in muscle stem cells during regeneration, finding increased fluctuations in activated cells mediated by mechanosensitive ion channels.

Redundant YAP and TAZ functions are essential for skeletal muscle regeneration

This study shows that YAP and TAZ redundantly regulate muscle regeneration by controlling proliferation and migration of muscle stem cells, revealing genetic redundancy as essential for regenerative robustness.

Serum C-terminal agrin fragment as a biomarker of age-related neuromuscular decline in men: influence of physical activity

This study finds that serum C-terminal agrin fragment (CAF) increases with age and is linked to neuromuscular decline and reduced physical function, with physical activity mitigating these effects in older men.

A positively selected microRNA controls a reversible aging program in striated muscle

The paper shows that inhibiting miR-128-3p improves muscle function and reduces aging-related pathology in multiple models.

The actomyosin cortex controls t-tubule remodeling in muscle

This study identifies the actomyosin cortex, regulated by Arpc5, as critical for t-tubule remodeling in muscle, linking it to muscle function and disorders.

Muscle fiber proteomics reveals sex- and fiber type-specific adaptations to resistance training

The paper examines sex- and fiber type-specific proteome changes in human skeletal muscle after resistance training, finding greater adaptations in type II fibers and sex differences in intermediate filament remodeling.

Transcriptomic profile of a rat jaw opener (anterior digastric) and a jaw closer (superficial masseter).

This study compares the transcriptomic profiles of three rat muscles with different functions, finding unique gene expression patterns related to their roles in jaw movement and metabolism.

Chronic activation of a key exercise signal transducer, CaMKII, drives skeletal muscle aging and sarcopenia

This study shows chronic CaMKII activation drives skeletal muscle aging and sarcopenia, and partial inhibition in aged muscle improves function and shifts the transcriptome toward a youthful state.