Neurogenesis and neuroplasticity mechanisms

Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signalling pathway.

This study shows FOXG1 regulates gliogenesis in the mouse neocortex through distinct roles in progenitors and postmitotic neurons, modulating the FGF signalling pathway to control astrocyte and oligodendrocyte production.

Human-specific morphoregulatory signatures in basal radial glia characterize neocortex evolution

This study identifies human-specific morphoregulatory signatures in basal radial glia that drive neocortex evolution through comparative chromatin and transcriptional profiling.

Metabolic Atlas of Early Human Cortex Identifies Regulators of Cell Fate Transitions

The paper identifies the pentose phosphate pathway's role in regulating radial glia cell fate during human cortical development using metabolic assays and genetic manipulations.

Adult Neurogenesis through Glial Transdifferentiation in a CNS Injury Paradigm

The paper shows that glial cells in Drosophila can transdifferentiate into neurons after CNS injury, providing a new mechanism for neurogenesis.

GABA mediates experience-dependent regulation of myelination in the mouse visual pathway.

This study shows that GABA signaling in the optic nerve mediates experience-dependent myelination, with binocular deprivation having less impact than monocular deprivation.

Adaptive Clonal Expansion Shapes Brain Development

The paper investigates NSPC proliferation dynamics in a mouse model, finding that adaptive clonal expansion by a small fraction of NSPCs can regenerate the entire neuronal population.

Neurosphere culture derived from aged hippocampal dentate gyrus

This paper introduces a novel neurosphere culture system using NPCs from adult and aged mice to study adult-born NPCs and their role in hippocampal function and aging.

Cell type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development

This study investigates the cell type-specific roles of FOXP1 in mouse neocortical development, revealing its impact on neurogenesis, gene expression, and cortical layering, with implications for ASD and FOXP1 syndrome.

Cilia Directionality Reveals a Slow Reverse Movement of Principal Neurons for Positioning and Lamina Refinement in the Cerebral Cortex

The paper shows that principal neurons in the cerebral cortex undergo reverse movement guided by cilia directionality, refining cortical lamination and contributing to neocortex evolution.

TRF2 Non-Telomeric Function is Indispensable for Neural stemness

This study shows TRF2's non-telomeric function is critical for maintaining neural stem cell identity by repressing differentiation genes through PRC2 recruitment and G4 motif binding.

Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone

This study identifies B2 cells as the primary neural stem cells in the adult mouse V-SVZ, replacing B1 cells postnatally to sustain neurogenesis.

Sox9 and Nfi transcription factors regulate the timing of neurogenesis and ependymal maturation in dopamine progenitors

This study identifies Sox9 and Nfi transcription factors as regulators of G0 entry and ependymal maturation in midbrain dopamine progenitors, with effects dependent on developmental timing.

Perinatal environmental enrichment affects murine neonates' brain structure before their active engagement with environment

This study shows environmental enrichment during the perinatal period alters brain structure in mice by P7, with changes in hindbrain, dorsal striatum, and medial habenula, mediated by maternal care.

Bdnf-Ntrk2 Signaling Promotes but is not Essential for Spinal Cord Myelination in Larval Zebrafish

The paper investigates the role of Bdnf-Ntrk2 signaling in spinal cord myelination in zebrafish, finding it contributes but is not essential for myelin formation.

Specific neuroblast-derived signals control both cell migration and fate in the rostral migratory stream

This study identifies EphB2 as a neuroblast-derived signal that controls migration and fate determination in the rostral migratory stream.

Running to remember: The effects of exercise on perineuronal nets, microglia, and hippocampal angiogenesis in female and male mice

This study examines how chronic treadmill exercise affects perineuronal nets, microglia, and hippocampal angiogenesis in male and female mice, linking these changes to spatial memory performance.

Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids

This study shows chronic glucocorticoid exposure alters lineage specification in human neural organoids by priming inhibitory neuron fate through transcription factors like PBX3.

Delayed transplantation of neural stem cells improves initial graft survival following stroke

This study shows that delayed transplantation of neural progenitor cells after stroke improves graft survival and proliferation in mice.

Evolutionary convergence of sensory circuits in the pallium of amniotes

This study compares the development and evolution of sensory circuits in the pallium of birds, lizards, and mammals, revealing divergent developmental trajectories but functional similarity in sensory processing.

TGIF2 is a major regulator of neural stem cell fate and neurogenic priming

The paper identifies TGIF2 as a key regulator of neural stem cell fate and neurogenic priming through transcriptomic and chromatin analysis in mouse brain development.

Neurod2/6 transcription factors control basal progenitor differentiation and sequential production of neocortical cell subtypes

This study shows that Neurod2/6 regulate basal progenitor differentiation and sequential production of neocortical cell subtypes by inhibiting Tbr2-dependent genetic programs.

Modeling cerebral development in vitro with L-MYC-immortalized human neural stem cell-derived organoids

This paper presents an organoid-based platform using L-MYC-immortalized human neural stem cells to model cerebral development in vitro, showing similar gene expression patterns to normal cortical development.

Detection of mitotic neuroblasts provides additional evidence of steady state neurogenesis in the adult small intestinal myenteric plexus

The paper detects mitotic neuroblasts in adult murine and human small intestinal myenteric plexus, providing evidence of steady-state neurogenesis.

Canonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate

The paper compares the roles of canonical and non-canonical PRC1 sub-complexes in neural stem cell regulation during neocortex development, finding canonical PRC1 has a more significant impact.

Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories

The paper links early cell cycle gene expression in cortical organoids to interindividual variability in infant brain growth trajectories.

Maternal Immune Activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells

This study identifies translational dysregulation and MAP2 phosphorylation differences in neural stem cells from offspring exposed to maternal immune activation.

Alcohol induces concentration-dependent transcriptomic changes in oligodendrocytes

This study shows that alcohol induces concentration-dependent transcriptomic changes in oligodendrocytes, affecting pathways like myelination and inflammation.

Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation

This study analyzes age-related changes in gene expression in the human dentate gyrus, identifying shifts in neurogenesis, maturation, and neuroinflammation across the lifespan.

Neuronal lysosome transfer to oligodendrocyte precursor cells: a novel mechanism of neuron-glia communication and its role in neurodegenerative disease

The paper identifies a novel neuron-glia communication mechanism where neurons transfer lysosomes to OPCs, linking this process to neurodegenerative disease progression.

Progenitor Heterogeneity in the Developing Cortex: Divergent and Complementary Roles of NG2-Progenitors and RGCs

This study investigates the functional and molecular differences between NG2-NPCs and GFAP-NPCs in brain development, revealing distinct roles in neurogenesis and gliogenesis.