Pancreatic and Hepatic Oncology Research

Unraveling the spatial distribution of CAF subsets in PDAC spheroids through a novel spatial flow cytometry approach

This study introduces SpheroMap Cytometry to analyze spatial CAF subsets in PDAC spheroids, revealing hypoxia's role in myCAF differentiation and stromal architecture.

Novel Insights into T-Cell Exhaustion and Cancer Biomarkers in PDAC Using Single Cell RNA Sequencing

This study identifies 16 novel cancer and T-cell markers in PDAC using scRNA-seq, highlighting T-cell exhaustion and potential therapeutic targets.

Targeting FGFR4 Abrogates HNF1A-driven Metastasis in Pancreatic Ductal Adenocarcinoma

This study identifies HNF1A as an oncogenic driver of PDAC metastasis through upregulation of FGFR4 and shows that FGFR4 inhibition reduces metastasis in vitro and in vivo.

Concordance of claudin-18.2 expression in biopsy, resection, and recurrent specimens: implications for zolbetuximab therapy in pancreatic ductal adenocarcinoma

This study evaluates the concordance of claudin-18.2 expression between biopsy, resection, and recurrent pancreatic ductal adenocarcinoma specimens, finding high agreement and supporting its use as a biomarker for zolbetuximab therapy.

Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1.

This study identifies NTN1/NEO1 as a key driver of pancreatic tumorigenesis and metastasis by promoting cancer stemness, EMT, and nerve innervation.

Differential control of growth and identity by HNF4α isoforms in pancreatic ductal adenocarcinoma

This study investigates the differential roles of HNF4α isoforms P1 and P2 in PDAC growth and differentiation, finding P2 supports growth better than P1.

PP2A activation drives aberrant macropinocytosis and cell death in pancreatic ductal adenocarcinoma

This study shows that PP2A activation inhibits macropinocytosis and induces cell death in pancreatic ductal adenocarcinoma, suggesting PP2A activators could be used with metabolic inhibitors as a new therapeutic strategy.

Myc and Kras cooperate in adult acinar cells to drive phenotypic heterogeneity, metastasis, and therapeutic resistance in a novel pancreatic cancer mouse model

This study develops a novel pancreatic cancer mouse model by expressing Myc and mutant Kras in adult acinar cells, showing metastasis and therapeutic resistance similar to human PDAc.

ODFormer: a Virtual Organoid for Predicting Personalized Therapeutic Responses in Pancreatic Cancer

ODFormer predicts personalized drug responses in pancreatic cancer by simulating patient-derived organoids using transcriptomic and mutational data, outperforming existing methods and improving clinical outcomes.

Glycation Stress-Driven Transcriptomic Signature Predicts Survival Benefit from Adjuvant Gemcitabine in Resectable Pancreatic Cancer.

The paper develops a 16-gene signature (MG-GEM) that predicts survival benefit from adjuvant gemcitabine in resectable pancreatic cancer based on glycation stress, outperforming existing signatures.

HOXB6 and HOXB8 control immune-cancer cell interactions in pancreatic cancer.

This study identifies HOXB6 and HOXB8 as regulators of immune-cancer cell interactions in pancreatic cancer, showing their role in promoting tumorigenesis and treatment resistance.

A spatial atlas of chemoradiation therapy in pancreatic cancer identifies cellular and microenvironmental determinants of persister populations

This study identifies cellular and microenvironmental factors contributing to radiation therapy resistance in pancreatic cancer using spatial transcriptomics and single-cell RNA sequencing.

Loss of HNF1b drives pancreatic Intraductal Papillary Mucinous Neoplasms (IPMN) initiation

This study shows that loss of HNF1B contributes to IPMN initiation and identifies its role as a tumor suppressor in pancreatic ductal cells.

Modeling cellular influence delineates functionally relevant cellular neighborhoods in primary and metastatic pancreatic ductal adenocarcinoma.

The paper introduces FunCN, a method to analyze cellular neighborhoods in PDAC, revealing distinct immune interactions in primary and metastatic sites.

Expression of β-catenin, LEF-1, MMP7 and SFRP5 associated with poor outcome in pancreatic cancer

The paper identifies β-catenin, LEF-1, MMP7, and SFRP5 as biomarkers associated with prognosis in pancreatic cancer using RNA sequencing, qPCR, and immunohistochemistry.

Plasminogen activator inhibitors orchestrate the immunosuppressive tumor microenvironment in pancreatic cancer

This study identifies Serpinb2 and Serpine1 as key factors in pancreatic cancer that remodel the tumor microenvironment to promote immune evasion and tumor progression.

Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis

This study shows that pancreas-specific BCKDK inhibition accelerates pancreatic cancer while systemic BCKDK inhibition reduces tumor formation.

Sequential Activation of Senescence and Apoptosis by ONG41008 Eliminated the Human Pancreatic Ductile Adenocarcinoma in nude mice and xenografted human lung cancer

ONG41008 eradicates pancreatic ductal adenocarcinoma and lung cancer in mice by inducing senescence-coupled apoptosis and inhibiting tumor blood vessels.

Spatial Biology and Organoid Technologies Reveal a Potential Therapy-Resistant Cancer Stem Cell Population in Pancreatic Ductal Adenocarcinoma

The paper uses spatial imaging and organoid models to identify therapy-resistant CD44v9+ cancer stem cells in PDAC and show that cabozantinib may enhance immunotherapy by altering the tumor microenvironment.

Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression

The paper identifies Dclk1-expressing cells in the pancreas and reveals their role in inhibiting pancreatic tumor progression through a tuft cell-ILC2 axis.

The Aging Microenvironment as a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer

This study shows that aging stromal cells in pancreatic cancer promote immune exclusion and metastasis, and that rejuvenating these cells can reverse these effects.

Investigating the prognostic value of KCNN4 gene expression in human pancreatic adenocarcinoma by bioinformatic analysis

This study investigates KCNN4 gene expression in pancreatic adenocarcinoma using bioinformatics, finding its expression correlates with survival and identifies associated biological functions.

Pancreatic cancer patient-derived organoids capture therapy response and tumor evolution

This study uses patient-derived organoids to predict drug response and track tumor evolution in pancreatic cancer.

High-Dimensional Protein Analysis Uncovers Distinct Immunological and Stromal Signatures Between Primary and Metastatic Pancreatic Ductal Adenocarcinoma

Targeting protein glycosylation and cholesterol metabolism in chemoresistant pancreatic cancer

This study identifies statins as effective in targeting chemoresistant pancreatic cancer by inhibiting cholesterol metabolism and protein glycosylation, showing clinical benefit in a phase 2 trial.

Ductal pancreatic cancer interception by FGFR2 abrogation

This study identifies FGFR2 as a key driver in early pancreatic tumorigenesis, showing that its inhibition can delay tumor formation and extend survival in mouse models.

ADT-1004: A First-in-Class, Orally Bioavailable Selective pan-RAS Inhibitor for Pancreatic Ductal Adenocarcinoma

ADT-1004, a pan-RAS inhibitor, shows strong antitumor activity in pancreatic ductal adenocarcinoma models with high selectivity and tolerable dosing.

Identification and Implications for Tumor Heterogeneity of a DNA Methylation-Based Signature Classifying Pancreatic Ductal Adenocarcinoma Based on their Cellular Origin

This study identifies a DNA methylation signature preserved during pancreatic carcinogenesis that distinguishes PDAC origins and influences tumor behavior.

Pathway-specific genomic alterations in pancreatic cancer across diverse cohorts

This study identifies ethnicity-specific genomic alterations in pancreatic cancer pathways among Hispanic/Latino and Non-Hispanic White patients using public datasets.

Effects of Inflammatory Factors on the Migration and Repair of Intestinal Mucosal Cells at Pancreaticojejunostomy Anastomosis: An Experimental Study in Beagle Dogs

This study compares the effects of mucosal-priority healing (PM-PJ) versus classic pancreaticojejunostomy (IPJ) on anastomotic healing and inflammatory markers in Beagle dogs, finding better healing and lower complications with PM-PJ.