Pancreatic and Hepatic Oncology Research

IL-1R1 Blockade Enhances CD40 Agonist-Mediated Immune Responses but Fails to Increase Efficacy or Mitigate Hepatotoxicity in Pancreatic Cancer

This study investigates the effect of IL-1R1 blockade on CD40 agonist therapy in PDAC, finding it does not improve efficacy and worsens liver toxicity.

Spatial Transcriptomics of IPMN Reveals Divergent Indolent and Malignant Lineages

This paper uses spatial transcriptomics to identify low-risk and high-risk expression programs in IPMN that correlate with exocrine and basal-like PDAC signatures, improving risk stratification.

Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression

This study analyzes clonal heterogeneity in human pancreatic ductal adenocarcinoma using single-cell and spatial transcriptomics, revealing transcriptional continua, clonal transitions, and spatially dispersed clones associated with metastasis.

Single-cell and spatially resolved atlas of pancreatic cancer reveals immunophenotypes associated with clinical outcome

This study integrates single-cell, spatial transcriptomics, and bulk RNA data to identify TME subtypes and spatial niches in PDAC that correlate with patient survival.

Stromal KITL/SCF promotes pancreas tissue homeostasis and restrains tumor progression

The paper identifies loss of stromal KITL as a mechanism promoting tumor progression in the pancreas by disrupting tissue homeostasis.

Dynamic dysregulation of Tenascin-X/Tenascin-C balance controlled by Transforming Growth Factor-beta leads to tumor cell proliferation during pancreatic carcinogenesis

This study shows that the balance between TNX and TNC, controlled by TGF-β, affects tumor cell proliferation in pancreatic cancer, suggesting TNX as a potential therapeutic target.

Hypoxia-induced histone methylation and NF-κB activation in pancreas cancer fibroblasts promote EMT-supportive growth factor secretion

The paper shows hypoxic fibroblasts in pancreas cancer use histone methylation and ROS-mediated NF-κB activation to produce growth factors that drive epithelial-mesenchymal transition in malignant cells.

CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma

This study investigates how CDK8 remodels the tumor microenvironment to resist KRASG12D inhibition in PDAC, showing that targeting CDK8 can overcome resistance and improve survival.

Ovarian cancer cell cluster inhibits pancreatic cancer progression

This study shows that ovarian cancer cell clusters inhibit pancreatic cancer progression more effectively than single cells through inflammation promotion and macrophage polarization.

A novel DNA repair protein, N-Myc downstream regulated gene 1 (NDRG1), links stromal tumour microenvironment to chemoresistance

This study identifies NDRG1 as a DNA repair protein that links pancreatic cancer stroma to chemoresistance by enhancing DNA damage repair through R-loop resolution.

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

This study shows that SMAD4 and KRAS mutations influence stromal composition and therapeutic response in pancreatic cancer models.

Enhancing PDAC Therapy: Decitabine-Olaparib Synergy Targets KRAS-Dependent Tumors

This paper shows that low-dose decitabine combined with olaparib enhances antitumor activity in KRAS-dependent pancreatic ductal adenocarcinoma, regardless of BRCA1/2 status.

Intraductal Papillary Mucinous Neoplasm Cellular Plasticity is linked with Repeat Element Dysregulation

This study uses spatial transcriptomics to show that IPMN subtypes form a molecular continuum originating from gastric-type cells, with repeat element expression linked to disease progression.

Transcriptomic Analysis Of The Relationship Between Pancreatic Ductal Adenocarcinoma Stromal Subtypes And Neural Invasion

The paper investigates the relationship between PDAC stromal subtypes and neural invasion using single-sample classifiers and RNA-seq data, finding activated stroma is enriched in neuro-invasive samples.

Simultaneous Targeting of KRAS and CDK4 Synergistically Suppresses Pancreatic Cancer Cells

This study shows that combining KRAS and CDK4/6 inhibitors synergistically suppresses pancreatic cancer cells and organoids with KRAS mutations, with durable effects even after drug washout.

Loss of PARP7 increases type I interferon signalling and prevents pancreatic tumour growth by enhancing immune cell infiltration

This study shows that loss of PARP7 in pancreatic cancer cells increases type I interferon signaling and enhances immune cell infiltration, leading to reduced tumor growth.

Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expression

The paper investigates how cancer-associated fibroblasts (CAF) influence tumor cell behavior in pancreatic ductal adenocarcinoma by driving EMT and altering cell subtypes, with IL-8 playing a key modulatory role.

MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and Metastasis

This study identifies MICAL2 as a super enhancer-associated gene that promotes pancreatic cancer growth and metastasis through multiple molecular mechanisms.

TRAIL receptor agonist TLY012 in combination with PD-1 inhibition promotes tumor regression in an immune-competent mouse model of pancreatic ductal adenocarcinoma

This study shows that combining TLY012 with PD-1 inhibition reduces PDAC tumor growth in mice by enhancing proinflammatory cytokines and immune cell infiltration.

Effect of Stroma-directed Drugs in Combination with Chemotherapy Against Pancreatic Cancer- a Preclinical Study

This study compares chemotherapy with and without stroma-directed drugs in a mouse model of pancreatic cancer, finding enhanced tumor growth inhibition and changes in tumor microenvironment.

Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer

This study shows that macropinocytosis regulates CAF subtype identity under metabolic stress in PDAC, impacting tumor stroma and therapeutic response.

Identifying simultaneous inhibition of riboflavin metabolism and MEK as a novel therapeutic strategy for pancreatic cancer

The paper identifies dual targeting of riboflavin metabolism and MEK as a novel therapeutic strategy for pancreatic cancer by showing synergistic suppression of PDAC xenograft growth.

Identification of Phosphotyrosine-Mutant Desmin in Human Pancreatic Cancer

The paper identifies a phosphotyrosine-mutant desmin in pancreatic cancer samples and discusses its potential role in metastasis and therapeutic targeting.

Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic responders

This study uses spatial multi-omics to identify TLS-associated immune niches in PDAC that correlate with improved survival in immunotherapy responders.

Allelic effects on KLHL17 expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33

The paper fine-maps a PDAC GWAS signal at chr1p36.33 and identifies KLHL17 as a target gene regulated by JunB/D, with potential implications for inflammation and PDAC risk.

A Rigorous Multi-Laboratory Study of Known PDAC Biomarkers Identifies Increased Sensitivity and Specificity Over CA19-9 Alone

This study evaluates combinations of PDAC biomarkers across multiple labs, finding improved sensitivity and specificity for early-stage detection compared to CA19-9 alone.

Drug resistant pancreatic cancer cells exhibit altered biophysical interactions with stromal fibroblasts in imaging studies of 3D co-culture models

This study investigates how drug-resistant pancreatic cancer cells alter biophysical interactions with stromal fibroblasts in 3D co-culture models using imaging and RNA-seq analysis.

3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure

The paper profiles the immune microenvironment of PanINs in 3D at single-cell resolution to understand inflammation's role in cancer progression and finds immune heterogeneity and correlations with PanIN grade.

CTHRC1+ Fibroblasts and SPP1+ Macrophages Synergistically Contribute to Pro-Tumorigenic Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma

This study identifies SPP1+ macrophages and CTHRC1+ fibroblasts as synergistic contributors to an immunosuppressive tumor microenvironment in PDAC, linked to poor prognosis.

The oncofetal protein IMP1 regulates the transcriptomic landscape to drive early events in pancreatic cancer progression and growth

This study shows IMP1 promotes early pancreatic cancer progression by altering the transcriptomic landscape and enhancing metastasis in mouse models.