Hematopoietic Stem Cell Transplantation

Local Oxygen Tension Dictates Hematopoietic Cell Growth and Potency

This study shows that local oxygen levels affect hematopoietic cell growth, metabolism, and potency, with low oxygen preserving less proliferative, stress-resistant cells.

Dormancy, not apoptosis, restricts hematopoietic stem cell mutagenesis during aging

This study shows that HSC dormancy, not apoptosis, limits mutagenesis in aging, with dormancy disruption accelerating mutation rates.

The Onset of Myeloid Differentiation in Hematopoietic Progenitors In Vivo is Coordinated with S-phase Progression

This study shows that myeloid differentiation in hematopoietic progenitors starts during S phase and is linked to chromatin changes and HOXA9 activity.

MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state

This study shows that MLL3 and MLL4 maintain hematopoietic stem cell multipotency by opposing a B-cell default state through distinct enhancer regulation mechanisms.

A single cell atlas defines perinatal factors that drive murine bone marrow development

The paper defines murine bone marrow mesenchymal and stromal cell progenitor identities and temporal emergence using a single cell atlas from fetal life to 18 months.

Chronic alcohol exposure drives inflammaging and transposon derepression in hematopoietic stem and progenitor cells

This study shows chronic alcohol exposure leads to inflammation, DNA damage, and transposon activation in hematopoietic stem and progenitor cells, with lasting effects on myeloid bias and immune responses.

Deciphering the HDAC6-Mediated Regulation of MLLT3 in Myeloid Progenitor Cell Fate: Insights into Stem Cell Differentiation Dynamics

This study identifies HDAC6's role in regulating MLLT3 levels via Hsp90 activation during myeloid differentiation, showing differential effects on MK and macrophage fate compared to monocytes.

Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow

The paper identifies adult hemogenic endothelial cells in mouse bone marrow that generate hematopoietic stem/progenitor cells and functional blood cells.

Imlifidase and EndoS enables semi-allogeneic bone marrow engraftment in sensitized mice under reduced intensity conditioning

The paper shows that imlifidase and EndoS desensitization allows long-term bone marrow engraftment in sensitized mice with reduced intensity conditioning.

Lineage-specific CK2α deletion reshapes the transcriptome of hematopoietic stem cells toward an immune-primed state

This study shows that deleting CK2α in hematopoietic stem cells (HSCs) alters their transcriptome toward an immune-primed state, with tissue-specific effects on inflammatory and immune-related genes.

Early postnatal Flt3+ hematopoietic progenitors realize fate-restricted and long-lived output in vivo

The paper tracks Flt3+ hematopoietic progenitors in vivo to show their lineage-restricted fates and long-lived output in immune cell compartments.

Corticosteroid resistance is predetermined by early immune response dynamics at acute Graft Versus Host disease onset

The paper identifies intrinsic immune cell mechanisms that drive steroid resistance in acute graft versus host disease before treatment.

Long-term clonal analysis using stochastic models reveals heterogeneity and quiescence of hematopoietic stem cells

The paper uses stochastic models to analyze clonal data from non-human primates, showing that HSC heterogeneity and quiescence are critical for long-term hematopoiesis.

Intravital imaging uncovers remodelling of humanised bone marrow-like niches

The paper uses intravital imaging to study dynamic remodelling of humanised bone marrow-like niches in mice, revealing vascular network formation and collagen matrix changes.

Sustained exposure to CAR-T cell secretome impairs human Hematopoietic Stem Cell function and is reversible by dual TNFα-IFNγ blockade

This study shows that sustained exposure of human HSPCs to CAR-T cell secretome impairs their function, but this effect is reversible with dual TNFα-IFNγ blockade.

Single Spectral Flow Cytometry Panel for Simultaneous Detection of Hematopoietic Stem, Progenitor, and Mature Lineages in Mouse Bone Marrow

The paper introduces a 19-marker spectral flow cytometry panel to simultaneously identify hematopoietic stem, progenitor, and mature cell lineages in mouse bone marrow.

Advanced Deep Learning Enables Prediction of Allogeneic Stem Cell Mobilization Success

This paper develops machine learning models to predict donor success in stem cell mobilization using clinical data, enabling early intervention and personalized strategies.

Limited bone marrow chimerism impairs cell competition in the thymus and causes leukemia

This study shows that limited bone marrow reconstitution impairs thymic cell competition and increases leukemia risk in gamma-c-deficient mice.

Altered stem cell properties of human hematopoietic stem and progenitor cells based on bone region location

The paper compares functional properties of human hematopoietic stem and progenitor cells (HSPCs) from two bone regions, finding similar intrinsic properties but distinct extracellular vesicle effects on quiescence.

Bnip3lb-driven mitophagy sustains expansion of the embryonic hematopoietic stem cell pool

This study shows that Bnip3lb-driven mitophagy maintains embryonic HSPC multipotency and expansion by regulating ROS levels, and enhances ex vivo hematopoietic potential of iPSC-derived HSPCs.

Differential effects of two common GVHD prophylaxis regimens on the gut microbiome: Results from the BMT CTN 1801 study

This study compares the effects of two GVHD prophylaxis regimens on the gut microbiome in allo-HCT recipients and finds that while PTCy reduces microbiome diversity and bile acid metabolism, it is linked to better clinical outcomes.

Neuropeptide Y deficiency in the bone marrow drives hematopoietic stem and progenitor cell aging

This study shows that neuropeptide Y deficiency in the bone marrow drives hematopoietic stem and progenitor cell aging, and NPY supplementation can reverse age-related defects.

Tracking Human HSCs and MPPs in Mice Reveals Distinct Clonal Dynamics and Responses to Pre-transplant Conditioning

Elevated endocytic trafficking mediated by GPRASP2 maintains HSC fidelity.

The paper shows that elevated endocytic trafficking via GPRASP2 maintains HSC quiescence and prevents functional exhaustion.

Platform-Imprinted Transcriptional and Clonal Remodeling of αβ and γδT Cells After Allogeneic Transplantation

This study examines how different transplantation platforms affect the clonal and transcriptional changes in αβ and γδT cells over time, finding that graft engineering has a lasting impact on βTCR clonality, while viral reactivation mainly drives expansion without altering repertoire structure.

Maternal Obesity Reprograms Differentiation Trajectories of Fetal Hematopoietic Stem and Progenitor Cells Through Altered Inflammatory Signaling

This study shows maternal obesity disrupts fetal bone marrow hematopoiesis by altering HSPC maturation, reprogramming lineage trajectories, and inducing inflammatory bias in a nonhuman primate model.

YY1-Mediated Polycomb Group Function Safeguards Hematopoietic Stem Cells from Premature Aging

This study shows that YY1's Polycomb group function is essential for maintaining HSC quiescence and preventing premature aging.

The extent of myeloid skewing in blood is a biomarker of biological aging in mice and humans

This study shows that the level of myeloid skewing in blood correlates with biological aging and disease in mice and humans.

Proliferative events ameliorate DNA damage accumulation without affecting function in hematopoietic stem cells

This study shows that increased HSC proliferation reduces age-related DNA damage without affecting function in mice.

An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans

The paper identifies an age-related expansion of an inflammatory and quiescent HSC subpopulation using integrated single-cell data.