Hematopoietic Stem Cell Transplantation

Novel markers for haemogenic endothelium and haematopoietic progenitors in the mouse yolk sac

The paper identifies novel molecular markers for haemogenic endothelium and haematopoietic progenitors in mouse yolk sac using single-cell RNA sequencing and pseudotime analysis.

Developmental programming of hematopoietic stem cell dormancy by evasion of Notch signaling

This study identifies a developmental program for hematopoietic stem cell (HSC) dormancy established during embryogenesis through evasion of Notch signaling, revealing a mechanism for long-term regenerative potential.

Monocyte and Lymphoid Lineages Share a Common Precursor Distinct from Neutrophils in Hematopoiesis

This study identifies a common precursor for monocytes and lymphoid lineages distinct from neutrophils using single-cell sequencing and lineage tracing.

Genetic and environmental imprints on T cell receptor repertoires as predictors of graft-versus-host disease

This study shows that donor T cell receptor repertoires are influenced by both HLA genetics and recent viral infections, with higher HLA heterozygosity and TCR-HLA coherence linked to increased GVHD risk.

Serum-free differentiation platform for the generation of B lymphocytes and natural killer cells from human CD34+ cord blood progenitors

This paper introduces a serum-free co-culture system using human bone marrow stromal cells to differentiate cord blood CD34+ progenitors into B and NK cells, offering a more physiologically relevant model for hematopoiesis research.

Functional Equivalence of Gamma- and X-Ray Irradiation for Long-Term Hematopoietic and AML Transplant Outcomes in Mice

This study compares the biological outcomes of gamma- and X-ray irradiation in mouse hematopoietic and AML transplants, finding they are functionally equivalent with proper dose calibration.

Proteostasis Remodeling Across Development Defines Fetal, Neonatal, and Adult Hematopoietic Stem Cell States

The paper identifies distinct proteostasis programs in fetal, neonatal, and adult hematopoietic stem cells, showing how proteostasis changes during development and impacts stem cell function.

A microgel bone marrow model of mesenchymal stem cell paracrine signaling supporting hematopoietic stem cell retention

This study develops a microgel-based bone marrow model to study mesenchymal stem cell (MSC) paracrine signaling's role in hematopoietic stem cell (HSC) retention and expansion.

Bioengineered bone marrows that can support stem cells and remodel to mimic human disease metabolism and chemotherapeutic effects

The paper develops a bioengineered bone marrow model that supports stem cells and mimics disease metabolism and chemotherapy effects, showing enhanced taurine metabolism and chemotherapy response.

ERAD Activity Distinguishes the Functional Heterogeneity of Hematopoietic Stem Cells

This study identifies ERAD activity as a predictive and heritable marker of hematopoietic stem cell function by linking cytokine signaling to proteostasis remodeling.

Graft protection by myeloid progenitor cells using lethal or non-lethal preconditioning.

This study shows that closely matched myeloid progenitor cells can protect skin and trachea grafts without lethal preconditioning or HSC transplantation.

Murine limb ischaemia induces structural and functional remodelling of local and distant bone marrow

This study examines how murine limb ischaemia affects bone marrow structure and function, revealing both local and systemic changes in haematopoiesis and myeloid cell function.

Endothelial protein C receptor CD201 is a better marker than SCA1 to identify mouse long-term reconstituting hematopoietic stem cells following septic challenge

This paper shows that CD201 is a more reliable marker than SCA1 for identifying long-term reconstituting hematopoietic stem cells in mice after septic challenge.

Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythroid Progenitors

The paper shows that mitochondrial content influences lineage commitment in megakaryocyte-erythroid progenitors, with mitochondria-rich cells favoring erythroid differentiation and mitochondria-poor cells favoring megakaryocyte differentiation.

Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche

This study shows that erythroid precursors in the bone marrow increase local oxygen levels after injury, promoting tissue repair by enhancing angiogenesis and osteogenesis.

Single-Cell Roadmap of Early Hemato-Endothelial Development: Functions of Atf3, Zfp711 and Bcl6b

The paper investigates the roles of Atf3, Zfp711, and Bcl6b in early hemato-endothelial lineage specification using scRNA-seq and KO mESCs, finding distinct effects on mesodermal and hematopoietic lineages.

Depletion of microenvironmental syndecan-2 impairs hematopoietic stem cell self-renewal and cytokine responses

This study shows that syndecan-2 in mesenchymal stromal cells, but not endothelial cells, supports HSC self-renewal and cytokine responses by modulating growth factor signaling.

Identification of a mesodermal progenitor for the pro-definitive angio-hematopoietic lineage

The paper identifies a mesodermal progenitor in mouse gastrula and human iPSC cultures that gives rise to pro-definitive angio-hematopoietic lineage cells, including yolk sac endothelium, blood islands, and macrophages.

A spatial atlas of human gastro-intestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology

The paper creates a spatial atlas of human gastrointestinal GVHD, identifying immune and epithelial changes that contribute to disease pathophysiology.

Atlas of Cynomolgus Macaque Hematopoiesis

The paper develops a single-cell transcriptomic map of cynomolgus macaque hematopoietic stem cells and progenitors, revealing molecular differences from humans and a direct differentiation pathway to megakaryocyte lineages.

Inhibition of farnesyltransferase activity diminishes hematopoietic stem cell ex vivo expansion ability

This study shows that inhibiting farnesyltransferase reduces the ex vivo expansion of human and mouse hematopoietic stem cells.

Mitofusin agonists improve the long-term repopulating activity of human cord blood HSCs after ex vivo culture

The paper shows mitofusin agonists enhance long-term repopulating activity of human cord blood HSCs in ex vivo culture without changing total nucleated cells or phenotypic HSCs.

Loss of cell cycle gatekeeping by 1 CNOT3 impairs hematopoietic stem and progenitor cell division and repopulating activity

This study shows that CNOT3 deletion in HSCs causes anemia, reduced bone marrow cellularity, and impaired hematopoietic reconstitution.

Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors

This study shows that linker histone H1.0 regulates HSPC fate bias toward lymphoid or myeloid differentiation, with H1.0 levels decreasing in response to IFN signaling.

A microbial metabolite protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

This study identifies desaminotyrosine (DAT) as a microbial metabolite that protects against graft-versus-host disease by promoting intestinal regeneration and modulating immune responses.

GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells

This study identifies GABA as a regulator of HSPCs produced by B cells and endothelial cells in the bone marrow, showing lower GABA levels reduce proliferation and increase B cell differentiation.

Targeting Endothelial PERK Accelerates Lymphoid Regeneration by Enhancing DLL4-NOTCH3 Signaling at the Pre-B Niche

This study identifies PERK activation in bone marrow endothelium as a regulator of DLL4-NOTCH3 signaling, which enhances lymphoid regeneration after transplantation.

Cyp7b1-inhibiting azoles as novel enhancers of hematopoietic stem and progenitor cell mobilization

This paper identifies Cyp7b1-inhibiting azoles as enhancers of HSPC mobilization, particularly effective in SCD patients.

Dose-Response Immunomodulatory Effects of Mesenchymal Stem Cells-Derived Culture-Conditioned Media in Acute Graft-versus-Host-Disease

This study optimizes the dose and timing of MSC-derived culture-conditioned media (CCM) to enhance its immunomodulatory effects on CD3+ T-cells in acute graft-versus-host disease.

Inflammation perturbs hematopoiesis by remodeling specific compartments of the bone marrow niche

The paper identifies two bone marrow compartments and shows inflammation affects them differently, with type I interferon causing changes in mesenchymal stromal cells.