Redox biology and oxidative stress

Receptor Tyrosine Kinase Profiling Identifies Chronic Constitutive Floodgate Oxidative Signaling in Glutathione-Independent Human Mammary Luminal Progenitor Cells

This study identifies cKIT as a key mediator of oxidative signaling in human mammary luminal progenitor cells and links its activation to poor outcomes in basal-like breast cancers.

Acute stimulation of glucose metabolism by H2O2 sustains theNADPH steady-state under oxidative stress

The paper shows that H2O2 increases NADPH production before depletion during oxidative stress by enhancing glucose metabolism.

A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity via engineered Gro3P-Glycerol shunt

This paper develops a genetically encoded bifunctional enzyme that reduces redox imbalance and lipotoxicity by enhancing Gro3P biosynthesis and glycerol shunt in mammalian cells.

Trans-kingdom coupling of redox signaling to environmental cell stress responses through multiphase partitioning.

This paper identifies RACK1 as a redox-regulated hub that coordinates cellular stress responses through condensate-based microdomains, linking environmental stress to immune signaling and translational control.

The transsulfuration pathway suppresses the embryonic lethalphenotype of glutathione reductase mutants in Caenorhabditis elegans

The paper shows that inactivating the NMD pathway suppresses the embryonic lethality of gsr-1 mutants in C. elegans by enabling the transsulfuration pathway to compensate for the loss of glutathione reductase function.

Distinct Roles for the Thioredoxin and Glutathione Antioxidant Systems in Nrf2-Mediated Lung Tumor Initiation and Progression

PRPS activity tunes redox homeostasis in Myc-driven lymphoma

This study identifies PRPS2 as a key regulator of redox homeostasis in Myc-driven lymphomas, showing that its inactivation causes reductive stress and cell death.

One-carbon metabolism enzyme Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration

Global mapping of thioredoxin interacting proteins in Neurospora crassa

This study identifies Trx interacting proteins in Neurospora crassa using affinity chromatography, revealing 1,998 potential redox-regulated proteins and their functional categories.

Synergistic Antitumor Activity of SUMO1 degrader and Oxaliplatin through G6PD Inhibition in Colorectal Cancer

This study shows that combining SUMO1 degrader HB007 with oxaliplatin enhances antitumor effects in colorectal cancer by inhibiting G6PD and inducing ROS-mediated apoptosis.

Redox signaling by hydrogen peroxide modulates axonal microtubule organization and induces a specific phosphorylation signature of microtubule proteins distinct from distress

This study shows hydrogen peroxide modulates axonal microtubule dynamics and induces distinct phosphorylation patterns in microtubule proteins through specific signaling pathways.

In-depth Characterization of S-Glutathionylation in Ventricular Myosin Light Chain 1 Across Species by Top-Down Proteomics

The paper identifies and quantifies S-glutathionylation in ventricular myosin light chain 1 across human, swine, and mouse cardiac tissues using top-down proteomics.

Measurement of the Glutathione Redox Potentials in Membraneless Organelles

The paper measures redox potentials in membraneless organelles and finds nuclear EGSH is stable and matches cytosolic levels, while MLOs reflect their environment.

Structure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosus

The paper identifies oxygen-induced tubular nanocompartments in Pyrococcus furiosus using proteomics and cryo-EM, revealing their structure and role in ROS protection.

The 1-Cys peroxiredoxin, PRDX-6, suppresses a pro-survival response, including the Flavin monoxygenase, FMO-2, that protects against fungal and bacterial infection

This paper shows that loss of PRDX-6 in C. elegans increases stress resistance, innate immunity, and longevity by upregulating FMO-2, which protects against fungal and bacterial infections.

Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins

The paper shows that eukaryotic Prx1/AhpC-type peroxiredoxins form heterooligomers, which modulate their structure and stability, challenging the previous belief in homooligomerization.

Profiling proteins involved in peroxynitrite homeostasis using ROS/RNS conditional proteomics

This study introduces Porp-L, a conditional proteomics tool for labeling ONOO--reactive proteins, and identifies new roles for Ero1a in ONOO- formation and ER as an ONOO- hotspot.

Characterization of the Glutathione Redox State in the Golgi Apparatus

The paper characterizes the redox state of glutathione in the Golgi apparatus, finding it to be highly oxidizing with low GSH concentration.

Environmental polysulfides promote protein disulfide bond formation of microorganisms growing under anaerobic condition

The paper shows environmental polysulfides promote protein disulfide bond formation in anaerobic microorganisms, aiding their survival.

Investigation of Axonal Beading Induced by Photo-oxidation

This study investigates axonal beading caused by photo-oxidation and shows that calcium chelation, microtubule stabilization, and oxygen scavenging can reduce oxidative stress-induced damage.

DHRS7 Integrates NADP+/NADPH Redox Sensing with Inflammatory Lipid Signalling via the Oxoeicosanoid Pathway

This study identifies DHRS7 as a redox sensor that converts NADP+/NADPH balance into inflammatory lipid signals via the oxoeicosanoid pathway, with implications for immune response and therapeutic targeting.

Enhancing NADPH to Restore Redox Homeostasis and Lysosomal Function in G6PD-Deficient Microglia

This paper investigates how replenishing NADPH can restore redox homeostasis and lysosomal function in G6PD-deficient microglia through metabolic pathway modulation.

A rubrerythrin locus of Clostridioides difficile efficiently detoxifies reactive oxygen species

This study identifies an oxidative stress operon in C. difficile that efficiently detoxifies reactive oxygen species, enabling the bacterium to survive in the host's intestinal environment.

Antioxidant role of the GABA shunt in regulating redox balance in blood progenitors during Drosophila hematopoiesis

This study identifies the GABA shunt's role in maintaining redox balance in Drosophila blood progenitors by regulating TCA cycle activity and GSH synthesis.

Hydrogen peroxide damage to scavenging function and ultrastructure of liver sinusoidal endothelial cells is prevented by n-acetyl-cysteine but not GSH

This study shows that hydrogen peroxide damages liver sinusoidal endothelial cells, reducing their scavenging function and causing structural changes, which can be mitigated by N-acetyl-cysteine but not glutathione.

The nuclear sulfenome of Arabidopsis: spotlight on histone acetyltransferase GCN5 regulation through functional thiols

This study identifies 225 redox-active nuclear proteins in Arabidopsis, including GCN5, modified by sulfenylation under oxidative stress, revealing their functional impact on protein interactions.

Protein aggregation capture assisted profiling of the thiol redox proteome

The paper introduces PACREDOX, a redox proteomics method that improves efficiency and compatibility with DIA, quantifying thousands of proteins and modified peptides in myocardial tissue.

Data-Independent Acquisition (DIA)-Based Label-Free Redox Proteomics (DIALRP) Reveals Novel Oxidative Stress Responsive Translation Factors

This study introduces DIALRP, a DIA-MS-based redox proteomics method, to identify oxidative stress-responsive translation factors in prostate cancer cells.

The rich evolutionary history of the ROS metabolic arsenal shapes its mechanistic plasticity at the onset of metazoan regeneration

This study investigates the role of ROS in regeneration across metazoans, finding conserved redox systems but variable mechanisms in different species.

Peroxiredoxin 2 mediates redox-stimulated adaptations to oxidative phosphorylation induced by contractile activity in human skeletal muscle myotubes

This study shows that PRDX2 mediates redox-stimulated adaptations to oxidative phosphorylation in human skeletal muscle myotubes exposed to contractile activity or H2O2.