Hippo pathway signaling and YAP/TAZ

p53 and YAP/TAZ-TEAD activities determine metaplastic heterogeneity in pancreatic cancer

This study shows that p53 and YAP/TAZ-TEAD activities regulate metaplastic heterogeneity in pancreatic cancer by influencing differentiation states and molecular subtypes.

YAP levels regulate anteroposterior elongation of hESC-derived gastruloids

This study shows that YAP activity levels control the elongation of h3D-gastruloids by affecting the establishment of anterior and posterior domains.

Mechanics-dependent Global Nuclear Eviction and Site-Specific Recruitment of YAP Regulates DNA Damage Responses

This study shows YAP translocates in response to DNA damage, enhancing DDR signaling globally and recruiting repair proteins locally.

Calcitonin-Driven Reactivation of the Hippo Tumor-Suppressor Cascade Attenuates YAP/TAZ Oncogenic Signaling in Glioblastoma

This study shows that calcitonin activates the Hippo pathway via CTR to inhibit YAP/TAZ in glioblastoma, with structural defects in CTR mutants impairing this effect.

YAP1 Depletion Enhances TAZ and its Complexation with TEAD4 and AP-1 Heterodimer C-JUN/FOSB to Promote Gastric Cancer Progression and Metastases

This study shows that inhibiting both YAP1 and TAZ in gastric cancer peritoneal metastases reduces tumor growth and progression by blocking their interactions with TEAD4 and AP-1 complexes.

YAP1 Contributes to The Development of Contractile Force and Sarcomere Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes

This study shows YAP1 promotes cardiomyocyte maturation, sarcomere structure, and contractility in human stem cell-derived cardiomyocytes.

Loss of CFIm activates YAP/TAZ and connects mRNA cleavage and polyadenylation inhibition to BRCAness

The paper shows that loss of CFIm activates YAP/TAZ and links mRNA cleavage and polyadenylation inhibition to BRCAness through DNA repair gene repression.

YAP/TEAD4-regulated placental alkaline phosphatases ALPP and ALPPL2 are immunosuppressive ectonucleotidases modulated by MAPK inhibitors

This study identifies YAP/TEAD4 as a regulator of ALPP/L2 expression and shows that MAPK inhibitors enhance their expression, improving ADC efficacy through immunomodulation.

p53 activity licenses transcriptional regulation by YAP/TAZ-TEAD to shape expression landscapes during tumorigenesis

The paper shows that p53 activity regulates YAP/TAZ-TEAD complexes to shape transcriptional landscapes during tumorigenesis by altering TEAD binding and gene regulatory networks.

Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

This paper develops a mouse model of RIT1M90I-driven lung cancer and identifies YAP/TEAD as a therapeutic target for RIT1-mutant lung cancer.

Piezo1-Yap1 signalling translates tissue mechanics into regenerative cell states.

This study identifies a mechanical signal, Piezo1-Yap1, that coordinates cell state transitions during regeneration by translating tissue stiffness into regenerative competence.

Sox2 Regulates Lateral Line Morphogenesis via Yap/Taz-Mediated Mechanotransduction

This study identifies Sox2 as a regulator of lateral line morphogenesis in zebrafish by modulating Yap/Taz-mediated mechanotransduction and cell proliferation.

Non-canonical HIPPO-MST1/2 promotes hyper-proliferation of pulmonary vascular cells through CDC20

The paper shows MST1/2 promotes hyper-proliferation and apoptosis resistance in PAH pulmonary vascular cells by up-regulating CDC20.

Breaking the redundancy: TAZ outperforms YAP1 in GIST progression

This study shows that TAZ, not YAP1, is more critical for GIST progression and that targeting TAZ could be a better therapeutic strategy.

C-terminal fusion partner activity contributes to the oncogenic functions of YAP1::TFE3

This study investigates how C-terminal fusion partners, specifically TFE3 domains, contribute to the oncogenic activity of YAP1::TFE3 fusion proteins in tumors.

Targeting the TEA DNA binding Domain of TEAD with a Peptide Inhibitor TEAi Suppresses Oncogenic Transcription and Tumor Growth

This paper develops TEAi, a peptide inhibitor targeting TEAD's DNA-binding domain, which suppresses TEAD-YAP/TAZ-driven transcription and tumor growth.

Caenorhabditis elegans Uses Canonical and Non-canonical Hippo signaling

This study identifies a conserved Hippo signaling pathway in C. elegans, showing canonical activity in epithelium and non-canonical regulation in intestine.

YAP charge patterning mediates signal integration through transcriptional co-condensates

This study shows YAP and Mediator form transcriptionally active condensates through charge patterning, enabling signal integration in stem cells.

Microtubule architecture connects AMOT stability to YAP/TAZmechanotransduction and Hippo signaling

This study identifies AMOT proteins as a mechanical rheostat linking microtubule architecture to YAP/TAZ mechanotransduction and Hippo signaling.

YAP regulates periosteal expansion in fracture repair

This study identifies YAP and TAZ as regulators of periosteal expansion during fracture repair, showing their role in cell proliferation and BMP4 regulation.

FvM4K1, a Serine/Threonine Kinase and Ste20 Homolog Positively Regulates Fruit Size via Hippo Signalling Pathway in Woodland Strawberry (Fragaria vesca)

This study identifies FvM4K1, a Ste20-like kinase in woodland strawberry, which positively regulates fruit size via the Hippo signaling pathway, contrasting its role in animals.

Development of a pipeline to evaluate YAP-TEAD inhibitor potential - direct TEAD inhibition represses cancerous growth in a NF2-mutant model of mesothelioma

The paper develops a pipeline to compare YAP/TAZ-TEAD inhibitors in mesothelioma models, identifying genetic compensation and off-target effects.

CD133+ Vesicles Mediate Resistance to RAS-ERK Inhibition Regulated by YAP Activation in Liver Cancer Cells

This study identifies CD133+ vesicles as mediators of resistance to RAS-ERK inhibition in liver cancer, regulated by YAP activation under stress conditions.

A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction

The paper identifies a fibroblast state called STIF that drives YAP-dependent regenerative programs and (pre)malignancy through mechanotransduction in response to tissue injury.

Fubylation as a Druggable Ubiquitin-Like Conjugation System Controlling Hippo Pathway Activity

This study identifies sCMF231, a small molecule that activates YAP by inhibiting FUBI-mediated fubylation of Annexin A2, thereby enhancing YAP transcriptional activity.

Transient YAP/TAZ inhibition exposes therapeutic vulnerabilities in advanced cancers

This study shows that transient YAP/TAZ inhibition can suppress tumor growth in advanced cancers and enhances immunotherapy when combined with immune checkpoint blockade.

TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway

The paper identifies small molecules that induce a cofactor switch in TEAD proteins from YAP to VGLL4, repressing pro-growth gene networks and showing anti-proliferative effects.

Conserved signals orchestrate self-organization and symmetry breaking of bi-layered epithelia during development and regeneration

This study identifies Hippo/YAP and Notch signaling coordination as essential for tissue architecture-driven cell fate decisions in bi-layered epithelia during development and regeneration.

TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions

The paper shows TEAD1/2 have both YAP/TAZ-dependent and -independent roles in neural progenitor lineage progression, promoting progression by inhibiting Notch and cooperating with INSM1.

Lats1/2 are essential for developmental vascular remodeling and biomechanical adaptation to shear stress

This paper shows that Lats1/2 are essential for vascular remodeling and response to shear stress in embryonic endothelial cells, leading to vascular defects and embryonic lethality.