Pain Mechanisms and Treatments

Human dorsal root ganglia neuronal cell line to study nociceptive signaling: a new pipeline for pain therapy.

The paper develops a human-derived in vitro model of nociceptive signaling using HD10.6 cells to study pain mechanisms and drug responses.

ENDOSOMAL SIGNALING OF PROTEASE-ACTIVATED RECEPTOR-2 AMPLIFIES HISTAMINE-INDUCED PAIN OF IRRITABLE BOWEL SYNDROME

This study shows that PAR2 endosomal signaling amplifies and sustains histamine-induced pain in IBS by maintaining H1R activity.

Targeting of subcellular metabotropic glutamate receptor 5 signaling to modulate pain transmission

This study shows that targeting mGlu5 in endosomes improves analgesia by inhibiting nuclear ERK1/2 signaling and reducing neuronal excitability in pain models.

A molecularly defined basalo-prefrontal-thalamic circuit regulates sensory and affective dimensions of pain in male mice

This study identifies a circuit involving mPFC Foxp2+ neurons that modulates sensory and affective pain in male mice, with therapeutic implications for chronic pain.

A small lipidated peptide targeting NaV1.8 channels attenuates osteoarthritic pain behavior and prevents bone erosion

This study shows that a lipidated peptide targeting NaV1.8 channels reduces OA pain and prevents bone erosion in animal models.

Homeostasis After Injury: How Intertwined Inference and Control Underpin Post-Injury Pain and Behaviour

The paper proposes a computational framework to model injury recovery and pain transitions using a partially observable Markov decision process, explaining paradoxical behaviors and chronic pain development.

Amygdalar Calcitonin Gene-Related Peptide Driven Effects of Cold Sensitivity Induced by Peripheral Neuropathy in Mice

This study investigates the role of CeA CGRP in neuropathic pain, finding that it modulates cold sensitivity differently based on injury type and hemisphere.

Pain-regulation circuitry as a predictor of chronic pain phenotypes

The paper identifies high and low PDA groups in chronic pain patients using clustering and shows differences in pain modulation, PAG connectivity, and behavioral markers, with machine learning models achieving above-chance classification.

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathy

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

Targeting GPR183 to reduce peripheral sensitization: evidence from rodent and human tissue analyses

This study identifies GPR183 as a driver of peripheral sensitization in rodents and humans, showing its role in pain pathways through immune cell activation and highlighting its potential as a therapeutic target.

Temporal Patterns of Brain Network Plasticity During the Onset and Maintenance of Neuropathic Pain in Male Mice

The paper examines brain network plasticity during neuropathic pain onset and maintenance in mice, finding stable connectivity during maintenance and changes at onset and post-surgery.

Transient silencing of spinal nociceptive neurons leads to a long-term reduction in joint pain mediated by recruitment of opioid activity.

The paper shows that SP-BOT induces two phases of pain relief in inflammatory arthritis, with long-term effects mediated by endogenous opioids.

Spared Nav1.8-Positive Nociceptors Drive Persistent Tactile Hypersensitivity After Sciatic Nerve Crush Injury in Mice

Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis

This study shows that Protectin DX reduces postoperative pain after tibial fractures in mice by activating GPR37 and promoting macrophage efferocytosis and neuronal signaling.

Peripheral Nerve Transection Predominantly Drives Sympathetic Nerve Sprouting in Mouse Dorsal Root Ganglia

This study compares nerve transection and crush injury models to show that transection drives sympathetic sprouting and pain, while crush injury causes pain through non-sympathetic mechanisms.

Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats

This study shows that repeated restraint stress worsens post-surgical pain and anxiety in rats through β-adrenergic receptor activation and spinal NLRP3-IL1β signaling.

Mimicking opioid analgesia in cortical pain circuits

The paper identifies a cortical circuit in mice modulated by opioids and develops a gene therapy to mimic opioid analgesia for chronic pain.

D1R-specific modulation of ACC mitigates chronic neuropathic pain

This study shows that modulating dopamine D1 receptor (D1R) activity in the anterior cingulate cortex (ACC) can alleviate chronic neuropathic pain in mice by altering neuronal excitability and circuit connectivity.

Senescence-associated Cdkn1a (p21) is upregulated in rodent dorsal root ganglion neurons across lesion-based neuropathic pain models

The paper analyzes transcriptome data to show Cdkn1a but not Cdkn2a is upregulated in DRG neurons across neuropathic pain models.

Neutrophil-neuronal crosstalk drives arthritis-induced pain

This study identifies SEMA4D and OSM as mediators of neutrophil-neuron communication in arthritis-induced pain, showing their role in neuronal sprouting and hypersensitivity.

GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain

This study identifies GPR30 in spinal CCK+ neurons and S1-SDH postsynaptic neurons as critical for neuropathic pain, suggesting it as a therapeutic target.

Age-related sensory dysfunction reconfigures the spinal circuitry for touch, itch and pain

This study shows that aging-related loss of touch receptor signaling leads to spinal circuit degeneration, causing itch and pain hypersensitivity in mice.

EEG Reveals Robust Within-Person but Unstable Between-Person Neural Encoding of Pain

This study uses EEG to show that within-person pain encoding is stable across time and cohorts, while between-person differences are less consistent.

Hierarchical organization of mechano-nociceptive pathways revealed by activity labeling

The paper maps nociceptive signaling architecture by combining activity labeling with single-cell RNA sequencing, revealing a hierarchical organization of mechano-nociceptor populations based on tissue domain and organ context.

Single-cell transcriptomics reveals probiotic reversal of neonatal morphine-induced gene disruptions underlying adolescent pain hypersensitivity.

The paper uses single-cell RNA sequencing to show that neonatal morphine exposure disrupts midbrain gene expression in adolescent mice, but probiotic treatment reverses these effects.

Gene Therapy for Efficient Suppression of T-Type Channels in Treating Diabetic Neuropathy

This paper describes a gene therapy approach using shRNAs to suppress T-type Ca2+ channels in DRG neurons to alleviate painful diabetic neuropathy.

Anatomical and molecular organization of the nociceptive medial thalamus

This paper creates an anatomical and molecular atlas of the nociceptive medial thalamus, identifying a distinct population of opioid receptor-expressing neurons involved in pain processing.

Meteorin resolves nociceptive hypersensitivity by reducing connexin-mediated coupling in satellite glial cells

This study shows meteorin reduces nociceptive hypersensitivity by decreasing connexin-mediated coupling in satellite glial cells, with long-lasting therapeutic effects in pain models.

The 5-HT1A receptor selective agonist NLX-204 displays analgesic activity in the knee osteoarthritis and plantar incisional post-operative pain models in rats

This study evaluates the analgesic effects of NLX-204, a 5-HT1A receptor agonist, in rat models of osteoarthritis and post-operative pain, showing dose-dependent pain relief compared to morphine.

Hippocampal CA3 Nex/Neurod6+ neuron-specific TNFR2 alleviates chronic neuropathic pain by sex-dependently engaging opioid and endocannabinoid pathways

This study shows that TNFR2 signaling in hippocampal Nex/Neurod6 neurons is critical for chronic neuropathic pain recovery, acting through sex-dependent opioid and endocannabinoid pathways.