Telomeres, Telomerase, and Senescence

Mechanistic Model of Telomere Length Homeostasisin Yeast

The paper develops a mathematical model to explain telomere length homeostasis in yeast, showing how feedback loops and delays lead to oscillations in telomere length.

UFMylation of MRE11 is essential for telomere length and hematopoietic stem cell survival

The paper identifies UFMylation of MRE11 as critical for telomere length and hematopoietic stem cell survival, showing its role in telomere maintenance without affecting DNA repair.

Roles of cellular senescence in driving bone marrow adiposity in radiation-and aging-associated bone loss

This study shows that cellular senescence drives bone marrow adiposity in radiation- and aging-associated bone loss through miR-27a upregulation and senolytic treatment reduces BMAT.

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment

This study identifies TPP1 mutations that impair telomerase processivity without affecting recruitment, showing processivity is critical for telomere length homeostasis.

Haplotype Diversity and Sequence Heterogeneity of Human Telomeres

This study uses long-read sequencing to analyze human telomere sequences, revealing sequence heterogeneity and non-canonical motifs.

RNAi and Ino80 complex control rate limiting translocation step that moves rDNA to eroding telomeres

The paper identifies RNAi and Ino80 complex as regulators of a translocation step that enables rDNA to replace telomeres in HAATIrDNA formation.

Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin

This study shows maternal diabetes causes premature senescence in the neuroepithelium, leading to neural tube defects, which can be prevented by senomorphic rapamycin.

DNA-RNA hybrid (R-loop): from a unified picture of the mammalian telomere to the genome-wide

The paper develops a method to detect and isolate stable DNA-RNA triplexes in complex genomes and defines terminal R-loop complexes in mouse and human genomes.

The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis

The paper investigates how cooperative assembly of the shelterin bridge regulates telomere length homeostasis by acting as a molecular timer.

Chromosome specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing

The paper develops a nanopore sequencing method to measure chromosome-specific telomere lengths in yeast, revealing stable lengths and new insights into telomere regulation.

RTEL1 Influences the Abundance and Localization of TERRA RNA

This study shows that RTEL1 helicase regulates TERRA RNA abundance and localization, with implications for telomere stability and disease.

The clinical and functional effects of TERT variants in myelodysplastic syndrome

The paper identifies TERT rare variants in MDS patients, showing shorter telomeres, younger age at diagnosis, and worse survival, suggesting their role in MDS pathogenesis and transplant outcomes.

Δ133p53α Protects Human Astrocytes from Amyloid-Beta Induced Senescence and Neurotoxicity

This paper shows that Δ133p53α protects human astrocytes from amyloid-beta-induced senescence and neurotoxicity by preventing DNA damage and SASP.

Clonal inactivation of telomerase promotes accelerated stem cell differentiation

This study shows that TERT inactivation accelerates stem cell differentiation and disrupts clone formation, independent of telomere elongation, and links TERT to MYC activity.

Alternative splicing is a developmental switch for hTERT expression

The paper identifies an alternative splicing mechanism that regulates hTERT expression during development, linking it to telomerase activity and disease.

Structural variant evolution after telomere crisis

The paper investigates structural variants (SVs) generated during telomere crisis, showing that BFB cycles and chromothripsis can occur in clones that escape telomere crisis.

Telomere maintenance pathway activity analysis enables tissue- and gene-level inferences

The paper analyzes telomere maintenance pathway activities in human tissues to identify gene-level and tissue-specific patterns of telomerase and ALT pathway activation.

Telomeric Double Strand Breaks Facilitate Formation of 5' C-Rich Overhangs in G1 Human Cells

The paper investigates the cellular response to telomeric double-strand breaks in G1 phase human cells, finding that they lead to 5' C-rich overhangs associated with the ALT pathway.

Rif1 regulates telomere length through conserved HEAT repeats

The paper identifies a domain in Rif1 containing HEAT repeats that regulates telomere length independently of its proposed DNA-binding function.

Bi-allelic MCM10 mutations cause telomere shortening with immune dysfunction and cardiomyopathy

This study identifies bi-allelic MCM10 mutations causing telomere shortening, immune dysfunction, and cardiomyopathy by impairing DNA replication and telomerase activity.

Programmed cell senescence in the mouse developing spinal cord and notochord

The paper identifies programmed cell senescence in the developing mouse spinal cord and notochord, showing its role in morphogenesis through senescence-associated secretory phenotype.

Method comparison studies of telomere length measurement using qPCR approaches: a critical appraisal of the literature

This review evaluates qPCR-based telomere length measurement methods, finding poor methodologic reporting and statistical rigor in existing studies.

Reduced RNA turnover as a driver of cellular senescence

The paper shows that RNA accumulation, driven by reduced RNA turnover and oxidative stress, contributes to the inflammatory state of senescent cells.

Inferring Telomerase Enzymatic Activity from Expression Data

The paper introduces a method to estimate telomerase enzymatic activity using a 13-gene expression signature and validates it across multiple datasets, finding a strong correlation with cancer stemness.

Telomerase Prevents Emphysema in Old Mice by Sustaining Subpopulations of Endothelial and AT2 Cells

This study shows that telomerase expression in old mice prevents emphysema by maintaining endothelial and AT2 cell populations through increased proliferation.

Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence

This study identifies chromatin modifiers and recombination factors essential for telomere folding in yeast, which is lost during replicative senescence.

Structurally distinct duplex telomere repeat-binding proteins in Ustilago maydis execute specialized, non-overlapping functions in telomere recombination and telomere protection

The paper identifies two structurally distinct telomere-binding proteins in Ustilago maydis with specialized, non-overlapping roles in telomere recombination and protection.

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

This study identifies 59 sentinel variants and two novel genes associated with telomere length using whole genome sequences from 109,122 trans-ethnic individuals.

Telomere damage induces internal loops that generate telomeric circles

The paper shows that telomere damage leads to internal loops (i-loops) that can form extrachromosomal telomeric circles, contributing to telomere erosion.

Human POT1 Prevents Severe Telomere Instability Induced by Homology Directed DNA Repair

This study shows that human POT1 prevents telomere instability caused by homology directed repair through proteomic and genetic analyses.