T-cell and B-cell Immunology

An early, novel arginine methylation of KCa3.1 attenuates subsequent T cell exhaustion.

The paper shows that early arginine methylation of KCa3.1 limits Ca2+-mediated NFAT1 activation, preventing T cell exhaustion during activation.

Immunodominance is a poor predictor of vaccine-induced T follicular helper cell quality

The paper investigates the relationship between CD4 T cell epitope immunodominance and vaccine-induced T follicular helper cell quality, finding that immunodominance is not predictive of helper quality.

IFNγ expression correlates with enhanced cytotoxicity in CD8+ T cells

The paper shows that IFNγ expression in CD8+ T cells correlates with increased cytotoxicity and identifies CRTAM as a regulator of IFNγ induction.

Layilin Regulates Treg Motility and Suppressive Capacity in Skin

This study identifies layilin as a regulator of Treg motility and suppressive capacity in skin, showing its role in adhesion and inflammation.

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling

This study shows that microbiota enhance CD39 expression in γδ IELs via TCR and IL-15 signaling, leading to regulatory IEL expansion and reduced inflammation.

Aging trajectories of memory CD8+ T cells differ by their antigen specificity

The paper examines how aging affects antigen-specific memory CD8+ T cells in EBV infection, finding distinct aging trajectories with changes in gene expression and TCR diversity.

SIRPγ modulates effector differentiation of human CD8 T Cells under suboptimal TCR stimulation: implications for immune homeostasis and autoimmunity

This study shows that SIRPγ reduces effector differentiation of CD8 T cells under weak TCR signals, linking its expression to immune homeostasis and autoimmunity risk.

Tim-3 Promotes Early Differentiation of Tbet+ Effector T Cells During Acute Viral Infection

Tumor-infiltrating CD27-IgD- regulatory B cells suppress cytotoxic CD8+T cell responses in renal cell carcinoma

The paper identifies CD27-IgD- regulatory B cells in renal cell carcinoma that suppress CD8+T cell responses, linking them to poor prognosis.

An amphiregulin reporter mouse enables transcriptional and clonal expansion analysis of reparative lung Treg cells

The paper develops an Areg reporter mouse to study Treg cell transcriptional and clonal expansion in lung repair, identifying 4-1BB agonism as a novel reparative mechanism.

Resolving ScRNA-Seq Signatures of Antigen-Specific CD4+ T Cells in Tolerance across Semi-Allogeneic Transplantation and Pregnancy

This study compares CD4+ T cell transcriptional states in transplant rejection and pregnancy tolerance using scRNA-seq, identifying distinct Tfh and Treg signatures.

Probabilistic migration events drive transient tissue residency of lymphocytes during homeostasis

The paper uses probabilistic modeling on a parabiosis dataset to analyze lymphocyte migration kinetics and dwell times across tissues, revealing cell type- and tissue-specific residency patterns.

Tmem127-mediated immune receptor degradation regulates T cell homeostasis through the common gamma chain

The paper identifies Tmem127 as a regulator of T cell homeostasis by controlling IL-7 receptor surface expression and common gamma chain interactions.

Neuropilin 2 functions as a co-inhibitory receptor to regulate antigen-induced inflammation and allograft rejection

This study identifies Neuropilin 2 (NRP2) as a co-inhibitory receptor that regulates antigen-induced inflammation and allograft rejection by modulating CD4+ T cell responses.

Tissue architecture dynamics underlying immune development and decline in the thymus

This study uses spatial transcriptomics and TCR sequencing in mice to analyze thymus changes across lifespan, revealing structural and transcriptional alterations linked to immune decline.

Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis

This study identifies an AP-1 regulatory axis that restricts Tγδ17 cell plasticity by stabilizing type 3 identity and preventing conversion to type 1 effectors during infection.

Intratumoral Treg ablation is sufficient to mediate tumor control systemically without autoimmunity

The paper shows that ablating tumor-infiltrating Tregs systemically controls tumors without autoimmunity, primarily through CD4+ T cells and cDC2s.

Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

The paper quantifies self-renewal and replacement rates of CD4+ TRM in skin and gut LP using fate mapping and models, finding site-specific differences in residency and turnover.

AnalyzAIRR: A user-friendly guided workflow for AIRR data analysis

AnalyzAIRR provides a user-friendly R package for analyzing bulk AIRR sequencing data, enabling comprehensive immune system analysis through advanced statistical and visualization tools.

Selective alteration to CD4 T cell differentiation by heterozygous IRF4L116R protects against neuroinflammation

This study shows that a heterozygous IRF4L116R mutation selectively impairs CD4 T cell differentiation into Th1, Th17, and Treg subsets, protecting against neuroinflammation without affecting overall T cell activation or memory.

Gene Regulatory Programs that Specify Age-Related Differences during Thymocyte Development

This study constructs a transcriptional and epigenetic atlas of T cell development in neonatal and adult mice, identifying age-related gene regulatory programs and a conserved regulator, Zbtb20.

Phased epigenetic fragility and stability accelerate the genetic evolution of B-cells

The paper shows that phased epigenetic fragility and stability in B-cells accelerate affinity maturation by modulating high-affinity outlier generation and removal during vaccine response.

Dissection of the microRNA transcriptomes of CD4+ T cell subsets in autoimmune inflammation identifies novel regulators of disease pathogenesis

The paper identifies miR-122-5p and miR-1247 as regulators of Th17 and Th1 cell functions in autoimmune inflammation, affecting EAE severity.

Basic interactions responsible for thymus function explain convoluted medulla shape

This paper presents a theoretical model showing that signaling pathways between medullary stroma and thymocytes shape the medulla's convoluted structure and influence thymocyte negative selection.

Actin waves guide an outward movement of microclusters in the lymphocyte immunological synapse

The paper identifies anterograde actin waves that move antigen-engaged microclusters away from the cSMAC, revealing a dual actin dynamics mechanism in T cell immunological synapses.

A linear ontogeny accounts for the development of naive, memory and tumour-infiltrating regulatory T cells in mice

This study maps the ontogeny of Treg subsets in mice, showing naive and effector/memory Treg are continuously replenished by de novo generation, with naive Treg being the main precursor of EM Treg in adults.

Learning Human T Cell Behaviors through Generative AI Embeddings of T Cell Receptors

The paper introduces Tarpon, a generative AI model that synthesizes TCR atlases to uncover T cell behavior patterns and cross-dataset mappings of T cell states.

Characterisation of distinct senescent-like T cell populations during healthy and unhealthy ageing

This study identifies a distinct senescent-like CD8 TEMRA cell population in older individuals with type 2 diabetes, linked to metabolic inflammation and impaired immune function.

Generation of antigen-specific and functionally stable Treg cells from effector/memory T cells for cell therapy of immunological diseases

This study converts effector/memory T cells into antigen-specific, functionally stable Tregs for immunological disease treatment.

Simulating CD8 T Cell Exhaustion: A Comprehensive Approach

The paper develops an in vitro model of CD8 T cell exhaustion and identifies a gene signature that defines the exhausted state in both in vitro and in vivo settings, with validation in human tumor samples.