T-cell and B-cell Immunology

GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice

The paper tracks GM-CSF expression in immune cells using reporter mice, identifying diverse sources and transient expression patterns in health and autoimmune neuroinflammation.

TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differnetiation

This study shows that TYK2 inhibition promotes Treg differentiation and function while inhibiting Th1 and Th17 differentiation, suggesting its potential for tolerance induction.

Premature thymic involution in young Foxn1lacz mutant mice causes peripheral T cell phenotypes similar to aging-induced immunosenescence

Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients

Early, adjuvant-responsive epigenetic programs in B cells imprint subsequent plasma cell survival and the duration of humoral immunity

The paper identifies early epigenetic programs in B cells that influence plasma cell survival and humoral immunity duration, showing that ZBTB20 deficiency affects antibody responses when disrupted early post-immunization.

CD4+ T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions

The paper quantifies mechanical forces on TCR:pMHC interactions in CD4+ T-cells, finding low forces that do not affect bond lifetimes, suggesting the immunological synapse stabilizes antigen recognition.

Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice

This study identifies T cell exhaustion in STING GOF mice as driven by lymphopenia, independent of type I interferons and intrinsic STING activation.

Dynamic Micropatterning Reveals Spatial Dynamics of B Cell Receptor Signaling and Immune Synapse Formation

This study uses dynamic micropatterning to analyze B cell receptor signaling and immune synapse formation, revealing distinct spatial distributions of activated proteins and actin-based protrusion repurposing.

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential

The paper identifies TR-TEX cells as distinct from TRM cells, showing they have unique transcriptional regulation and respond differently to PD-1 inhibition.

Aging-Associated Microbiota Drives Treg Dysfunction via TNF Signaling

This study shows that aging microbiota impairs Treg cell function through TNF signaling, leading to inflammation and immune aging.

ASCL1 primes medullary thymic epithelial cell programs required for central tolerance

The paper identifies ASCL1 as a key regulator of mTEC function and central tolerance by analyzing single-cell RNA sequencing data from thymoma patients and mouse models.

FGL-1 binding to LAG-3 inhibits T cell activation via disruption of CD28 and TCR signaling

This study shows FGL-1 binding to LAG-3 inhibits T cell activation by disrupting CD28 and TCR signaling through Lck mislocalization and reduced phosphorylation.

Data-driven simulations elucidate how lymphocyte motility behaviors influence cell-cell interactions within germinal centers

The paper develops a computational framework to quantify lymphocyte motility behaviors and predict their impact on B-T interactions in germinal centers, finding that differential motility enhances B-T interaction rates.

The quest continues: Human CD4+ CD16+ CD56+ "exTreg" resemble NKT cells instead

The paper re-evaluates the identity of CD4+ CD56+ CD16+ cells in human PBMC, finding they resemble NKT cells rather than exTreg, and explores Treg stability and Tr17 induction for therapeutic applications.

Quantifying The Impact of Bulk TCR-Seq Methodological Choices on The Profiled T Cell Repertoire

This study evaluates how methodological choices in bulk TCR-Seq affect T cell repertoire profiling, finding that RNA/DNA quality significantly impacts results and that low quantities can be partially compensated by increasing PCR cycles.

De novo identification of the specificities of recurrent human T cell receptors

The paper identifies antigen specificities of public TCRs by screening TCR panels against viral genomes and reference strains, revealing cross-reactive TCRs against coronaviruses, influenza, and herpesviruses.

The transcription factor BATF pioneers the differentiation program of cytolytic effector CD8+ T cells through the direct interaction with IRF4

This study shows BATF is essential for early chromatin remodeling and effector CD8+ T cell differentiation through its interaction with IRF4.

Genomic Specificity of Anti-TCR mAbs determined by single-cell RNAseq

The paper identifies TCR-V gene usage patterns in T cells sorted by anti-TCR mAbs using single-cell RNAseq and finds enriched ERV1-family LTR expression in specific TRBV regions.

Clonal Expansion and Diversification of Germinal Center and Memory B Cell Responses to Booster Immunization in Primates

This study examines memory and germinal center B cell responses in rhesus macaques after booster immunization, finding that high affinity memory B cells form a reservoir that participates in immune development regardless of boosting site.

The earliest changes in the translatome upon human T cell activation

This study examines early transcriptional and translational changes in human T cells within four hours of activation, revealing dynamic gene expression and translation initiation patterns.

T cell ectosomes promote antibody responses through cognate TCR-pMHC interactions

This study shows that T cell ectosomes, containing TCRs, enhance B cell antibody production by engaging cognate pMHCII, providing a new mechanism of T cell help.

Expansion of mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis

The paper examines T cell changes in mammary glands during pregnancy and lactation, finding an expansion of T effector cells and similarities to intestinal T cells.

Multiparametric optimization of human primary B-cell cultures using Design of Experiments

This study optimizes human primary B-cell culture conditions using Design of Experiments, identifying CD40L and IL-4 as critical factors for viability and IgE class-switching.

SATB1 maintains naive-like identity in antiviral CD8⁺ T cells by limiting chromatin remodelling at effector gene loci.

This study identifies SATB1 as a regulator that maintains naive CD8+ T cell identity by restricting chromatin remodelling at effector gene loci, preventing premature differentiation during viral infection.

Aging-Associated Autoimmunity in Genetically Diverse UM-HET3 Mice Shows a Female Sex Bias

The paper shows that female UM-HET3 mice develop age-related autoimmunity and sialadenitis with a female sex bias, potentially reflecting benign autoimmunity linked to aging.

miR-34c-5p is a novel regulator of T cell differentiation that targets FOXP3

This study identifies miR-34c-5p as a regulator of T cell differentiation that targets FOXP3, revealing a negative feedback loop in iTreg development.

A variational deep-learning approach to modeling memory T cell dynamics

The paper develops a variational deep-learning method to model memory T cell dynamics in mice, revealing phenotypic diversity and long-term heterogeneity in lung-resident TRM cells.

CREB REGULATES FOXP3+ST-2+ TREGS WITH ENHANCED IL-10 PRODUCTION

This study shows that CREB knockout in Foxp3+ Tregs increases IL-10 and ST-2 expression, enhancing their suppressive function and preventing gut inflammation.

Regulatory T cells epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunity

This study reprograms autoreactive effector T cells into stable regulatory T cells using epigenetic modification, showing improved efficacy in treating autoimmune neuroinflammation.

Type 1 Regulatory T cells induced by intestinal epithelial cells respond to food antigen

The paper identifies small intestinal FOXP3-IL-10+ Tr1 cells as antigen-specific responders to food antigens presented by intestinal epithelial cells, establishing their role in maintaining food tolerance.