Tuberculosis Research and Epidemiology

Insight into the structure and interactions of the M. tuberculosis Mce-associated membrane proteins Mam1A-1D

This study characterizes the structure and interactions of M. tuberculosis Mam1A-1D proteins using X-ray and neutron scattering, revealing their tetrameric structure and disulfide bridges, and their interaction with LucA.

Integrative genomics sheds light on the immunobiology of tuberculosis in cattle

This study integrates transcriptomic, genomic, and GWAS data to identify genes and eQTLs associated with the PB transcriptome response to M. bovis infection in cattle.

In vitro and in vivo synergy of Vancomycin and β-lactams against drug-resistant Mycobacterium tuberculosis and Non-tuberculous mycobacteria

This study identifies synergistic combinations of Vancomycin and β-lactams against drug-resistant mycobacteria, showing improved bactericidal activity and reduced bacterial load in vitro and in vivo.

Targeting CCRL2 enhances therapeutic outcomes in a tuberculosis mouse model

This study shows that targeting CCRL2 with an antibody-drug conjugate improves TB treatment in mice by reducing inflammation and enhancing immune responses.

Multi-omic latent variable data integration reveals multicellular structure pathways associated with resistance to tuberculin skin test (TST)/interferon gamma release assay (IGRA) conversion in Uganda

The paper integrates multi-omic data to identify latent factors associated with resistance to TB conversion, revealing pathways related to multicellular structure and cell-cell interactions.

CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis.

This study investigates CD4 T cell dysfunction in chronic tuberculosis and links it to bacterial recrudescence in mice.

ATLS2021-PA (A Sphingolipid mimetic): Upcoming Host Directed Therapy for Acute and MDR Tuberculosis

This paper demonstrates that ATLS2021 enhances sphingolipid levels and improves anti-tubercular efficacy, including sensitizing MDR TB to Rifampicin and inducing immunogenic responses.

Genome-wide association study in Brazil identifies genetic susceptibility to tuberculosis with single-cell gene effects

This study identifies genetic risk factors for tuberculosis in Brazil using GWAS and single-cell transcriptomics, finding SNPs associated with gene expression in multiple cell types.

Master control of protein secretion by Mycobacterium tuberculosis

This study identifies a master control mechanism for protein secretion in M. tuberculosis involving the ESX-4 system and reveals its role in virulence and host cell interaction.

Multiomic analysis identifies suppressive myeloid cell populations in human TB granulomas.

This study identifies suppressive myeloid cell populations in human TB granulomas using spatial transcriptomics and single-cell immunophenotyping, revealing IDO1+ dendritic cells as key regulators of immune suppression.

Candidate transmission survival genome of Mycobacterium tuberculosis

This study identifies a candidate transmission survival genome of Mycobacterium tuberculosis by exposing it to model aerosol fluid and analyzing gene contributions to survival during transmission.

Activin A mediated KAT8 expression induces ferroptosis during Mycobacterium tuberculosis infection

The paper identifies Activin A's role in regulating KAT8 and NRF2 to induce ferroptosis during Mycobacterium tuberculosis infection, showing inhibition reduces TB burden.

Macrophages of diabetes and tuberculosis co-morbid conditions show perturbed differentiation and metabolic signatures

This study examines how diabetes and tuberculosis co-morbid conditions alter macrophage differentiation and metabolic profiles, revealing perturbed pathways and immune responses.

Identification of a unique TUBB3+ cell population in the tuberculosis granuloma

The paper identifies a TUBB3+ cell population in TB granulomas across multiple species and patients, distinct from known cell types and present in other infections.

Direct thin-layer agar for bedaquiline-susceptibility testing of Mycobacterium tuberculosis at BSL2 level yields high accuracy in 15 days from sputum processing.

This paper evaluates thin-layer agar (TLA) for faster, accurate bedaquiline-susceptibility testing of Mycobacterium tuberculosis directly from sputum samples, achieving high sensitivity and reducing time to result.

Gluconeogenesis plays a critical role in mycobacterial biofilm formation

This study shows that gluconeogenesis in Mycobacterium tuberculosis is essential for biofilm formation, as it generates glucose for cellulose production in the biofilm matrix.

Targeting ALOX5/LTA4H driven granuloma caseation as a host-directed strategy for control of TB associated lung damage

This study shows that targeting ALOX5/LTA4H signaling reduces TB-induced lung damage and improves bactericidal activity through macrophage-driven inflammation.

Identification of chemical features that influence mycomembrane permeation and antitubercular activity

The paper identifies chemical features affecting mycomembrane permeation and antitubercular activity using a bioorthogonal assay and machine learning.

Physiologic recovery of Mycobacterium tuberculosis from drug injury: A molecular study of post antibiotic effect in mice

This study investigates the physiologic recovery of Mycobacterium tuberculosis in mice after antibiotic treatment, finding that recovery is slow, sequential, and incomplete, with longer treatment leading to slower recovery.

Deconvoluting drug interactions based on M. tuberculosis physiologic processes:Transcriptional disaggregation of the BPaL regimen in vivo

The paper uses SEARCH-TB to analyze drug interactions in M. tuberculosis by measuring transcriptional responses to the BPaL regimen in vivo, showing complex effects of drug combinations.

Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection

This study identifies in vivo chemical-genetic interactions in tuberculosis that reveal novel drug targets and mechanisms, showing differences from in vitro results and highlighting metabolic dependencies affecting drug efficacy.

Human memory CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses

The paper shows that most Mtb-specific CD4+ T cells from LTBI individuals recognize infected macrophages, but some require exogenous antigen, and identifies effector functions associated with TB protection.

Necrosis drives susceptibility to Mycobacterium tuberculosis in PolgD257A mutator mice

This study shows that mtDNA mutations in PolgD257A mice increase susceptibility to Mtb by impairing innate immunity and promoting necrosis.

The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control

This study identifies hypoxia as a key driver of immune dysfunction in TB granulomas, correlating with bacterial persistence.

An LNP-mRNA vaccine provides potent immunogenicity and protection against Mycobacterium tuberculosis

This study develops an LNP-mRNA vaccine against Mycobacterium tuberculosis that induces strong immune responses and protects mice from infection, with potential for human application.

Sanfetrinem, an oral beta-lactam antibiotic repurposed for the treatment of tuberculosis

This paper identifies sanfetrinem cilexetil as a promising oral beta-lactam antibiotic for tuberculosis treatment through preclinical studies showing its activity against Mtb and potential for repurposing.

A state-structured pharmacodynamic framework separating resistance, tolerance and persistence, applied to Mycobacterium tuberculosis and Staphylococcus aureus

This paper develops a state-structured pharmacodynamic model to distinguish antibiotic resistance, tolerance, and persistence in bacteria, showing that resuscitation of dormant cells is critical for shortening treatment duration.

A repressor co-regulatory network integrates iron acquisition to mycobacterial stress tolerance

This study identifies a repressor co-regulatory network linking iron acquisition to mycobacterial stress tolerance through the PhoP-Lsr2 interaction and bfrB regulation.

Timing matters in Macrophage / CD4+ T cell interactions: An agent-based model comparing Mycobacterium tuberculosis host-pathogen interactions between latently infected and naïve individuals

This paper develops an agent-based model to simulate immune responses to Mycobacterium tuberculosis infection, showing that early macrophage-CD4+ T cell interactions in latent TB infection reduce bacterial load through TNF and IFNγ mechanisms.

CCR2 recruits monocytes to the lung, while CX3CR1 modulates positioning of monocyte-derived CD11cpos cells in the lymph node during pulmonary tuberculosis

This study investigates the roles of CCR2 and CX3CR1 in monocyte-derived cell trafficking during pulmonary tuberculosis, showing CCR2's role in lung and lymph node accumulation and CX3CR1's impact on positioning in lymph nodes.