Hematopoietic Stem Cell Transplantation

An epigenetically distinct HSC subset supports thymic reconstitution

This study identifies an epigenetically distinct HSC subset, Kitlo, that supports better thymic and T-cell reconstitution in mice and humans.

E2f coordinates the cell cycle and cell fate of hematopoietic progenitors to drive stress myelopoiesis

This study identifies E2f as a regulator that coordinates cell cycle activity and cell fate decisions in hematopoietic progenitors to drive stress myelopoiesis.

Single-cell and in situ spatial analyses reveal the diversity of newly born hematopoietic stem cells and of their niches

The paper uses single-cell and spatial transcriptomics to study hematopoietic stem and progenitor cell diversity and their niches in zebrafish development.

ATP2B1 expression identifies human hematopoietic stem cells across ontogeny with superior repopulation and self-renewal capacity

The paper identifies ATP2B1 as a marker for human LT-HSC subpopulations with distinct repopulation and self-renewal capacities across ontogeny.

Medium-dose irradiation impairs long-term hematopoietic stem cell functionality and hematopoietic recovery to cytotoxic stress

This study examines the long-term effects of medium-dose irradiation and 5-FU on hematopoietic stem cells and hematopoietic recovery in mice, finding that irradiation causes sustained impairments and selective depletion of MHC class II- HSCs.

PERK Signaling Maintains Hematopoietic Stem Cell Pool Integrity under Endoplasmic Reticulum Stress by Promoting Proliferation

This study shows PERK signaling promotes HSC proliferation under ER stress to maintain stem cell pool integrity by activating mTOR, without relying on apoptosis.

Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host Disease

This study uses spatiotemporal single-cell analysis to track T cell clonal dynamics and phenotypic plasticity in GVHD, revealing links between TCR features, clonal expansion, and disease severity.

Multimodal analysis of in vitro hematopoiesis reveals blood cell-specific genetic impacts on complex disease traits

The paper uses in vitro hematopoiesis systems to analyze gene expression and chromatin organization during HPC formation, identifying genetic impacts on blood traits and disease.

Developmental Timing Establishes Hematopoietic Stem and Progenitor Cell Lineage Bias

The paper uses zebrafish developmental lineage tracing and single-cell RNA sequencing to show that early HSPCs favor lymphoid lineage while later HSPCs skew towards erythroid, with early HSPCs contributing to adult lymphocytes.

Stable platelet production via the bypass pathway explains the long-term reconstitution capacity of hematopoietic stem cells

This study identifies a myeloid bypass pathway that supports long-term HSC reconstitution by analyzing single-cell transplantation data with a mathematical model.

Low Dose Methotrexate has Divergent Effects on Cycling and Resting Human Hematopoietic Stem and Progenitor Cells

This study shows low dose methotrexate (LD-MTX) differentially affects cycling and resting human hematopoietic stem and progenitor cells (HSPC), reducing proliferation while preserving clonogenicity in non-cycling cells.

Influence of Hypoxia on a Biomaterial Model of the Bone Marrow Perivascular Niche

This study investigates how hypoxia affects hematopoietic stem and progenitor cells in an engineered bone marrow model, showing improved cell maintenance under hypoxic conditions when oxygen shock is reduced.

Targeting RhoA activity rejuvenates aged hematopoietic stem cells

This study shows that reducing RhoA activity in aged HSCs lowers nuclear tension, restores chromatin structure, and improves regenerative capacity and lineage balance.

Deciphering of single-cell chromatin accessibility and transcriptome reveals the discrepancy for ex vivo human erythropoiesis

The paper analyzes ex vivo human erythropoiesis at single-cell chromatin accessibility and transcriptome levels to identify discrepancies and constraints in erythrocyte regeneration.

15-PGDH inhibition promotes hematopoietic recovery and enhances HSC function during aging

This study shows that inhibiting 15-PGDH improves hematopoietic stem cell function and recovery in aged mice without affecting normal blood production.

A subset of Haematopoietic Stem Cells resists Plasmodium infection-induced stress by uncoupling interferon sensing and metabolic activation

The paper identifies two HSC subsets with distinct responses to Plasmodium infection, showing that BiotinHi HSCs remain functional by maintaining a stemness-associated metabolic profile despite sensing inflammation.

The Role of N-acetylcysteine Amide in Acute Graft-versus-host Disease Mouse Model

This study investigates N-acetylcysteine amide (NACA) as a prophylactic treatment for acute GvHD in a mouse model, showing reduced disease severity and improved survival without affecting donor engraftment.

Predictive Modeling of acute Graft-versus-Host-Disease using Machine Learning on Immune Cell and Cytokine Profiles at Engraftment

This study uses machine learning to predict acute Graft-versus-Host-Disease (aGvHD) based on immune cell and cytokine profiles at engraftment, finding high accuracy with cytokine and T-cell data.

Clonal dynamics and somatic evolution of haematopoiesis in mouse

This study examines clonal dynamics and somatic evolution in mouse haematopoiesis, finding that stem cells accrue mutations at a rate similar to human progenitors and exhibit distinct age-related patterns.

Harnessing Global HLA Data for Enhanced Patient Matching in iPSC Haplobanks

The paper develops an algorithm to prioritize HLA haplotypes for global patient coverage, showing that a global haplobank could more than double HLA matching coverage compared to national approaches.

Leukemia confers a durable imprint on healthy hematopoietic stem and progenitor cells

This study shows that healthy hematopoietic stem and progenitor cells (HSPCs) retain long-term transcriptomic and epigenetic changes after exposure to acute myeloid leukemia (AML) blasts, leading to enhanced inflammatory and metabolic responses upon secondary challenge.

Single-cell mass cytometry maps the evolution of immune cell signatures predictive of acute graft-versus-host disease

The paper uses mass cytometry to identify immune cell signatures predictive of acute graft-versus-host disease (aGvHD) and shows how these signatures evolve over time.

Hematopoietic stem cells undergo bidirectional fate transitions in vivo

This study reveals bidirectional fate transitions between myeloid-biased and lineage-balanced hematopoietic stem cells using clonal phylogenetic tracing.

Loss of Ing4 enhances hematopoietic regeneration in multipotent progenitor cells

This study shows that loss of Ing4 promotes quiescence and transcriptional priming in multipotent progenitor cells, enhancing their regeneration capacity upon stress.

GraphMatch: Knowledge Graphs for Allogeneic Stem Cell Matching

GraphMatch is a scalable graph database for allogeneic stem cell matching, demonstrating efficient search performance with large datasets.

HSCs and Tregs cooperate to preserve extramedullary hematopoiesis under chronic inflammation

The paper shows that HSCs and Tregs work together to maintain extramedullary hematopoiesis during chronic inflammation.

Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool

This study identifies Sema4A as an extrinsic factor that protects myeloid-biased HSCs from inflammatory stress, preserving functional diversity in the hematopoietic stem cell pool.

Single-cell profiling reveals a novel RAB13+ endothelial subpopulation and profibrotic mesenchymal cells in the aged human bone marrow

This study identifies novel RAB13+ endothelial and profibrotic mesenchymal cells in aged human bone marrow using single-cell RNA sequencing and spatial transcriptomics.

Stochastic Modeling of Hematopoietic Stem Cell Dynamics

This study develops a stochastic spatial model of hematopoietic stem cells to capture variability, predict homeostasis, and simulate stress-induced perturbations.

Glycan-Mediated Mechanosensing Regulates Megakaryocyte-Biased Hematopoietic Stem Cell Subsets.

This study identifies B4GALT1 as a key regulator of HSPC lineage decisions by modulating glycosylation and mechanosensing in the bone marrow niche.