Hematopoietic Stem Cell Transplantation

Secondary lymphoid organ endothelial cells prime alloreactive CD4+ T cells to trigger acute graft-versus-host disease

This study identifies blood endothelial cells in secondary lymphoid organs as key APCs that prime donor CD4 T cells, leading to acute graft-versus-host disease.

Spinal Cord Injury Imprints a Glucocorticoid-Driven Failure State in Hematopoietic Stem Cells

This paper shows spinal cord injury causes hematopoietic stem cells to enter a repressed state due to glucocorticoid surges, leading to long-term hematopoietic failure, which can be reversed by early glucocorticoid receptor blockade.

Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow

The paper shows that skull bone marrow is vulnerable to age-related decline, contradicting previous claims of resilience, and highlights its role in blood and immune health.

Impaired IL-10 Receptor Signaling Leads to Inflammation Induced Exhaustion in Hematopoietic Stem Cells

This study shows that IL-10 receptor signaling prevents inflammation-induced hematopoietic stem cell exhaustion, and its blockade accelerates aging and promotes clonal expansion of Jak2V617F mutant HSCs.

Plcl1 Regulates Hematopoietic Stem Cell Function During Aging and Stress by Modulating Calcium Dynamics

This study identifies Plcl1 as a regulator of calcium dynamics in hematopoietic stem cells, affecting their function during aging and stress.

Quantifying HLA transcripts by genotype in chimeric mixtures at single-cell resolution

This paper introduces scrHLA-typing, a method to quantify HLA transcripts in single cells using long-read sequencing, showing its ability to detect allele-specific expression in post-transplant relapse samples.

Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

This paper introduces a 3D hemogenic gastruloid model to study infant acute myeloid leukemia origins, showing MNX1-driven transformation of erythroid-myeloid progenitors.

Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset

This study identifies exhausted-like effector CD8 T cells as key drivers of oral mucosal cGVHD by analyzing single-cell RNA sequencing data from biopsies collected at disease onset.

Polymer-based culture system enables expansion of human haematopoietic stem and progenitor cells while preserving ageing-associated transcriptional programs

This study develops a polymer-based culture system to expand human haematopoietic stem and progenitor cells while preserving age-related transcriptional programs, enabling research on ageing haematopoiesis.

Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging

This study identifies PF4 as a key regulator of HSC aging, showing that PF4 deficiency accelerates aging and that PF4 supplementation can rejuvenate aged HSCs.

RNA helicase Ddx21 safeguards fetal HSPC expansion by recruiting Kdm5a to epigenetically sustain ribosomal and hematopoietic gene transcription

This study identifies Ddx21's role in fetal hematopoiesis by showing it recruits Kdm5a to maintain epigenetic regulation of ribosomal and hematopoietic gene transcription, essential for HSPC expansion.

Differences between in vivo and ex vivo models drive divergent perturbation outcomes

The paper compares perturbation outcomes in in vivo and ex vivo hematopoietic stem cell models, finding systematic biases and challenges in predicting in vivo effects from ex vivo data.

A single cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis

This study identifies new functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis using multiomic single cell analyses and functional assays.

Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche

The paper identifies Vcam1-expressing endothelial and stromal cells as critical for HSPC retention in the zebrafish CHT niche through Itga4-Vcam1 interactions.

Bone Marrow Adipokine Mediates Hematopoietic Regeneration and Stem Cell Fitness

This study identifies BM adipocyte-derived Resistin, regulated by RXR signaling, as critical for HSC self-renewal and hematopoietic regeneration after myeloablation.

Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis

The paper shows that myeloid-biased hematopoiesis in aging is due to altered LT-HSC/ST-HSC ratios, not HSC clone heterogeneity.

Distinct causes of three phenotypic hallmarks of hematopoietic aging

This study identifies distinct causes for three hematopoietic aging phenotypes using mouse models and single-cell analysis, showing HSC accumulation is NFκB-independent, functional impairment is HSC-autonomous NFκB-driven, and myeloid bias is driven by the NFκB-altered bone marrow environment.

Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis

This study shows that chronic glucocorticoid exposure, via HIF1 deficiency in adrenocortical cells, promotes HSPC expansion and myeloid bias while impairing B-cell development through GR-dependent mechanisms.

Restraint of TGFβ family signaling by SMAD7 is necessary for hematopoietic stem cell maturation in the embryo.

This study shows that SMAD7 restrains TGFβ and BMP signaling to enable pre-HSC maturation into HSCs during embryonic hematopoiesis.

2-Methoxyestradiol Treatment Prevents Graft-versus-Host Disease While Preserving Graft-versus-Leukemia Effect in Mice

This study shows that 2ME2 treatment reduces GVHD mortality and morbidity while maintaining GVL activity in mice.

A bone marrow stromal secretome screen identifies semaphorin 3A as a regulator of hematopoiesis

The paper identifies semaphorin 3A as a secreted factor from revitalized MSCs that regulates HSPC proliferation in steady state and stress conditions.

Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT

This paper shows that pretransplant targeting of TNFRSF25 and CD25 with a TL1A-Ig fusion protein and low-dose IL-2 expands recipient Tregs, reducing GVHD after HSCT while preserving GVL.

Impaired DNA damage response and inflammatory signalling underpins hematopoietic stem cell defects in Gata2 haploinsufficiency

This study identifies how Gata2 haploinsufficiency disrupts HSC function and drives pre-leukemic changes through DNA damage and inflammatory signaling, with ASXL1 mutations exacerbating these defects.

The hidden predictors of human haematopoietic clonal fate

The paper identifies clonal fate modules in human HSPCs using machine learning, revealing molecular predictors of lineage commitment and improving dendritic cell purity for immunotherapy.

A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche.

This paper introduces a double reporter strategy to identify a non-migratory subset of hematopoietic stem cells in the bone marrow niche and shows their dynamic interactions during stress and aging.

Targeting mitochondria mitigates chemotherapy-induced bone marrow dysfunction

This paper shows that chemotherapy causes long-term bone marrow dysfunction by impairing hematopoietic stem cells, which can be reversed by mitochondrial-targeted treatment.

Functional Comparison to Ezh2 Reveals PRC2-Independent Functions of Jarid2 in Hematopoietic Stem Cell Lineage Commitment

The paper compares the roles of Jarid2 and Ezh2 in hematopoiesis, finding Jarid2 has PRC2-independent functions affecting lineage commitment.

Comparative single-cell lineage bias in human and murine hematopoietic stem cells

The paper investigates lineage commitment bias in human and murine hematopoietic stem cells, finding that variation in myeloid and lymphoid engraftment is stochastic and not due to cell-intrinsic bias.

Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity

This paper develops a system to predict hematopoietic stem cell diversity using quantitative phase imaging and machine learning, capturing temporal kinetics rather than single snapshots.

Dose- and time-dependent effects of cobalt protoporphyrin IX on granulocyte mobilization and metabolic markers in mice

This study evaluates the dose- and time-dependent effects of CoPP on granulocyte mobilization and metabolic markers in mice, finding a dose-dependent mobilizing effect with mild side effects.