Hematopoietic Stem Cell Transplantation

Dynamic activity of Erg promotes aging of the hematopoietic system

This study identifies Erg as a master transcription factor whose upregulation during aging is critical for adult hematopoietic stem cell function and resistance to leukemogenesis.

Regulation of hematopoietic stem cell (HSC) proliferation by Epithelial Growth Factor Like-7 (EGFL7)

This study shows that EGFL7 promotes HSC expansion and survival, and its absence leads to reduced HSPC numbers and increased quiescence, with rEGFL7 treatment reversing these effects.

Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules

The paper characterizes Tet2-mutant HSCs using multi-omic data and identifies ECM molecules as regulators of self-renewal in pre-leukemic HSCs.

Who am I? Optimal Tissue for Germline Genetic Testing Post-Stem Cell Transplantation

This study identifies optimal tissues for germline genetic testing post-stem cell transplantation, finding buccal swabs and nails have higher donor DNA than eyebrow hair.

IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion

This study shows that IL-27 limits HSPC differentiation during infection and prevents stem cell exhaustion by reducing monocyte production and maintaining HSPC function.

Distinct origin and fate for fetal hematopoietic progenitors

The paper identifies distinct roles for embryonic multipotent progenitors (eMPP) and hematopoietic stem cells (HSC) in fetal hematopoiesis and immune system development.

Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice

This study shows that reducing dysfunctional CD150high HSCs in old mice alleviates aging phenotypes and extends lifespan.

Use of human AML cells to study graft-versus-leukemia immunity in xenogeneic mouse models of GVHD

The paper describes methods for studying graft-versus-leukemia immunity in xenogeneic mouse models using human AML cells and PBMCs.

Integrated local and systemic communication factors regulate nascent hematopoietic progenitor escape during developmental hematopoiesis

This study identifies signaling pathways supporting nascent HSC release during EHT using single-cell RNA sequencing from human embryonic cells.

A Pax3 lineage gives rise to transient haematopoietic progenitors

The paper identifies a transient population of Pax3 lineage cells in the mouse fetal liver and circulation with haematopoietic progenitor characteristics and the ability to generate myeloid and erythroid cells.

Inflammatory Mesenchymal Stromal Cells and IFN-responsive T cells are key mediators of human bone marrow niche remodeling in CHIP and MDS

Clonal analysis of murine HSC self-renewal and differentiation in native hematopoiesis

This study uses a clonal analysis approach to investigate HSC self-renewal and differentiation in native hematopoiesis, revealing patterns of clonal expansion and lineage commitment.

Maintenance of haematopoietic stem cells by JAK inhibition and increased tyrosine-unphosphorylated STAT5

This study shows that JAK inhibition increases uSTAT5 levels, which promotes HSC maintenance and stemness, and reveals a new role for uSTAT5 in controlling HSC function.

Differential responses and recovery dynamics of HSPC populations following Plasmodium chabaudi infection.

This study examines how hematopoietic stem and progenitor cells (HSPCs) respond and recover following Plasmodium chabaudi infection, revealing distinct recovery patterns and changes in proliferation rates.

Reducing oxidative stress improves ex vivo polymer-based human haematopoietic stem and progenitor cell culture and gene editing

This study shows reducing oxidative stress enhances ex vivo growth of human haematopoietic stem and progenitor cells in polymer-based cultures and enables efficient gene editing.

A Comparative assessment of T-Cell response of Healthy donors and Acute Graft-versus-Host-Disease Patients: Customizing immune monitoring platform

This study compares T-cell responses between healthy donors and aGVHD patients to optimize PHA and IL-2 concentrations for in vitro T-cell proliferation studies.

Mitochondrial activity-driven hematopoietic stem cell fate and lympho-myeloid lineage choice is first established in the aorta-gonad-mesonephros

This study shows mitochondrial activity regulates HSC fate and lineage choice during embryonic hematopoiesis in the AGM, with low mitochondrial activity promoting myeloid bias and high activity favoring lymphoid bias.

Cellular and molecular networks of intercellular signaling in bone marrow hematopoiesis

The paper develops CellSIP to analyze cell-cell signaling in hematopoiesis, identifies feedback mechanisms and pathway correlations, and provides a resource for exploring intercellular signaling.

The Clonal Hematopoiesis-associated Gene Srcap Plays an Essential Role in Hematopoiesis

This study shows that Srcap is essential for normal hematopoiesis, HSC function, and genomic integrity, with loss of Srcap causing DNA damage and p53 pathway activation.

Clonal analysis of fetal hematopoietic stem/progenitor cell subsets reveals how post-transplantation capabilities are distributed

The paper compares functional properties of fetal and adult hematopoietic stem/progenitor cells through transplantation, revealing differences in lineage bias and clonal multi-lineage differentiation.

A Single Trophoblast Layer Acts as the Gatekeeper at the Endothelial-Hematopoietic Crossroad in the Placenta

The paper shows that parietal trophoblast giant cells regulate hematopoietic stem cell development in the placenta through paracrine signaling.

Hemogenic endothelium of the vitelline and umbilical arteries is the major contributor to mouse fetal lympho-myelopoiesis

The paper identifies hemogenic endothelium in vitelline and umbilical arteries as a major source of fetal lympho-myeloid progenitors in mice, showing their transient contribution before definitive HSCs emerge.

Characterization of Multicellular Niches Supporting Hematopoietic Stem Cells Within Distinct Zones

This study identifies two distinct multicellular niches in fetal liver and adult bone marrow that support hematopoietic stem cells with different cycling states and lineage biases.

Systematic single-cell analysis reveals dynamic control of transposable element activity orchestrating the endothelial-to-hematopoietic transition

This study systematically analyzes single-cell data to show how transposable elements dynamically regulate the endothelial-to-hematopoietic transition through epigenetic changes and inflammatory signaling.

A molecular switch: Ro5-3335 drives hematopoietic stem cell division and clonality through distinct RUNX1 binding partners

This study identifies Ro5-3335 as a chemical that increases HSC clone number and clonal diversity by altering RUNX1 binding partners in zebrafish and mouse models.

Plasma Cell-Free RNA Captures Immune Dynamics and Predicts GVHD after Hematopoietic Stem Cell Transplantation

This study uses plasma cell-free RNA profiles to monitor immune dynamics and predict graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation.

In Utero Hematopoietic Stem Cell Transplant for Fanconi Anemia

This study demonstrates that in utero hematopoietic stem cell transplantation (HSCT) without conditioning can effectively engraft donor cells in FA mouse models, achieving high donor chimerism and potentially offering a safe prenatal treatment for FA.

Rapid Response of Neutrophils Determined by Shortest Differentiation Trajectory and New Insight into Cell Cycle Kinetics and Chronological Order of Progenitor States

This study elucidates the cell cycle kinetics and chronological order of progenitor states in hematopoiesis, revealing that lineage commitment precedes cell division and that neutrophils have the shortest differentiation trajectory.

Donor whole blood DNA methylation is not a strong predictor of acute graft versus host disease in unrelated donor allogeneic haematopoietic cell transplantation

This study investigates whether donor DNA methylation can predict acute graft-versus-host disease (aGVHD) in HCT, finding that a classifier developed from methylation data failed to validate in an independent cohort.

Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

The paper identifies fetal liver macrophage subpopulations and shows their role in regulating granulopoiesis and the HSC niche during embryogenesis.