Treatment of Major Depression

Immediate and Long-Term Electrophysiological Biomarkers of Antidepressant Behavioral Effects After Subanesthetic Ketamine and Medial Prefrontal Cortex Deep Brain Stimulation Treatment

This study examines electrophysiological biomarkers of antidepressant effects from ketamine and mPFC DBS in rats, finding correlations between specific brain activity patterns and behavioral improvements.

Ribosomal dysregulation: A conserved pathophysiological mechanism in human depression and mouse chronic stress.

This study identifies ribosomal dysregulation as a conserved mechanism in human depression and mouse chronic stress, linking stress-induced changes in ribosomal proteins and pseudogenes to synaptic dysfunction.

Co-aggregation and parallel aggregation of specific proteins in major mental illness

The paper investigates co-aggregation and parallel aggregation of specific proteins in major mental illness by analyzing brain samples and cell culture experiments.

Emotion-induced frontal α asymmetry predictsrelapse after discontinuation of antidepressantmedication

The paper shows that reduced frontal alpha asymmetry during sad mood induction predicts antidepressant relapse after medication discontinuation.

Ketamines rapid antidepressant effects are mediated by Ca2+ - permeable AMPA receptors in the hippocampus

This study shows that ketamine's rapid antidepressant effects in mice are mediated by increased expression of Ca2+-permeable AMPA receptors in the hippocampus through reduced calcineurin activity.

Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making.

This study shows that therapeutic ketamine doses reduce the aversive impact of losses in decision-making in rhesus macaques without affecting gains or other cognitive functions.

Electroacupuncture prevents astrocyte atrophy to alleviate depression

This study shows electroacupuncture prevents astrocyte atrophy in mice with depression-like behaviors, suggesting astrocytes as a target for treatment.

Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes

Multi-omic modeling of antidepressant response implicates dynamic immune and inflammatory changes in individuals who respond to treatment

This study develops a machine learning tool to integrate multi-omic data and identify biomarkers for antidepressant response, finding dynamic immune and inflammatory changes are associated with treatment success.

Histone H3 serotonylation dynamics in dorsal raphe nucleus contribute to stress- and antidepressant-mediated gene expression and behavior

The paper investigates how serotonin modifies histone H3K4me3Q5ser dynamics in the dorsal raphe nucleus under stress and antidepressant exposure, showing its role in gene expression and behavior.

Synapses, predictions, and prediction errors: a neocortical computational study of MDD using the temporal memory algorithm of HTM.

This study uses a temporal memory algorithm to model how synaptic atrophy in the neocortex affects predictive capacity and prediction confidence, linking it to major depressive disorder symptoms.

Multimodal Data Integration Advances Longitudinal Prediction of the Naturalistic Course of Depression and Reveals a Multimodal Signature of Disease Chronicity

This study uses machine learning to predict 2-year MDD chronicity by integrating proteomics with clinical data, showing improved accuracy over psychiatrists' predictions.

Cingulate prediction of response to antidepressant and cognitive behavioral therapies for depression: Theory, meta-analysis, and empirical application

The paper identifies neural predictors of response to antidepressants and cognitive behavioral therapy in depression using meta-analysis and empirical data.

Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

The paper shows ketamine suppresses futility-induced passivity in zebrafish by modulating astroglial calcium through norepinephrine signaling.

The Long Noncoding RNA FEDORA is a Cell-Type- and Sex-Specific Regulator of Depression

The paper identifies FEDORA, a lncRNA with sex- and cell-type-specific effects on depression in females.

A novel antidepressant acting via allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons

The paper identifies YY-23, a compound that inhibits GluN2D-containing NMDARs in GABAergic interneurons, showing antidepressant effects in animal models.

G protein-biased LPAR1 agonism promotes prototypic antidepressant effects

This study identifies G protein-biased LPAR1 agonism as a mechanism underlying the antidepressant effects of TCAs like amitriptyline, distinguishing them from SSRIs.

Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior

This study shows that deleting Crtc1 in mice causes hippocampal metabolic impairments linked to depressive-like behavior and identifies ebselen as a potential treatment.

NUDT6, the Antisense Protein of FGF2 Gene, Plays a Depressogenic Role by Promoting Inflammation and Suppressing Neurogenesis without Altering FGF2 Signaling

This study shows that NUDT6, an antisense protein of FGF2, induces depression-like behavior by promoting inflammation and reducing neurogenesis without affecting FGF2 signaling.

Experimenter sex modulates mouse biobehavioural and pharmacological responses

This study shows that the sex of human experimenters affects mouse behaviors, stress responses, and drug responses like ketamine, mediated by CRF neurons.

Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties

This study investigates mitochondrial dysfunction and bioenergetic changes in induced neural progenitor cells and iPS-neurons from MDD patients compared to controls.

Characterizing ketamine-induced dissociation using human intracranial neurophysiology: brain dynamics, network activity, and interactions with propofol

This study examines ketamine-induced brain dynamics in humans using intracranial recordings, identifying oscillatory changes linked to antidepressant and dissociative effects.

Independent Replication and Drug-specificity of an Antidepressant Response Polygenic Risk Score

The paper replicates an antidepressant response polygenic risk score (PRS-AR) in an independent trial and shows drug-specific effects and improved remission rates with stratification.

Ketamine and its metabolite 2R,6R-hydroxynorketamine promote ocular dominance plasticity and release TRKB from inhibitory control without changing perineuronal nets enwrapping parvalbumin interneurons

This study shows ketamine and its metabolite R,R-HNK enhance ocular dominance plasticity by releasing TRKB from PTPσ inhibition without altering PNNs.

Statins and antidepressants induce similar in vitro gene expression responses

This study compares gene expression responses to statins and antidepressants, finding shared immune pathway perturbations and associations with monocyte and platelet metrics.

Predictive Patterns of Antidepressant Response from Pre-Treatment Reward Processing using Functional MRI and Deep Learning: Key Results from the EMBARC Randomized Clinical Trial

This paper uses deep learning on pre-treatment reward processing fMRI and clinical data to predict antidepressant outcomes, achieving up to 37% variance explained and remission prediction with NNT 2-4.

Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine

This study shows that tianeptine, but not fluoxetine, reduces avoidant behavior in mice prenatally exposed to fluoxetine, suggesting it may be a better treatment for altered serotonergic systems.

Molecular Characterization of Depression Trait and State

The paper integrates transcriptomic data with in-silico analyses to identify cellular, molecular, and causal pathways in trait and state depression.

Tiam1-mediated synaptic plasticity drives comorbid depressive symptoms in chronic pain

This study identifies Tiam1-mediated synaptic plasticity in the ACC as a driver of depressive symptoms in chronic pain and shows that ketamine's antidepressant effects are mediated by blocking this pathway.

Rapid acting antidepressant (2R,6R)-hydroxynorketamine (HNK) targets glucocorticoid receptor signaling: a longitudinal cerebrospinal fluid proteome study

This study identifies HNK's mechanism of action by analyzing CSF proteome changes, showing its impact on glucocorticoid receptor signaling and potential upstream regulators.